Alsita M 100 Mgtablet (10 Tab)

ALSITA M 100 MG TABLET

ALSITA M 100 MG TABLET is a prescription medication manufactured by ALKEM LABORATORIES LTD., used for the management of type 2 diabetes mellitus in adults.

• Composition: Each tablet contains Sitagliptin (100 mg) and Metformin (500 mg). Sitagliptin is a DPP-4 inhibitor, which increases insulin release and decreases glucose production by the liver. Metformin is a biguanide that reduces glucose production in the liver and improves the body's sensitivity to insulin.

• Uses: This medicine is prescribed to control high blood sugar levels in adults with type 2 diabetes, especially when diet and exercise alone are insufficient. It helps improve the body's insulin response and reduces the risk of long-term diabetes complications such as kidney damage, nerve problems, heart disease, and vision loss.

• Dosage and Administration: ALSITA M 100 MG TABLET should be taken orally with meals, typically once or twice daily, or as directed by a healthcare professional, to minimize gastrointestinal side effects. The tablet should be swallowed whole with water and not crushed, chewed, or broken. Consistent daily administration at the same time is recommended for optimal results. Do not discontinue the medication without consulting your doctor.

• Side Effects:

  • Common: Upper respiratory tract infection, headache, diarrhea, nausea, vomiting, stomach pain/upset, flatulence, metallic taste, and joint pain.
  • Serious (rare): Lactic acidosis (symptoms include muscle pain, weakness, trouble breathing, stomach pain), pancreatitis (severe abdominal pain possibly radiating to the back), and hypoglycemia (low blood sugar, especially when combined with other diabetes medications or insulin). Long-term use of metformin may also lead to vitamin B12 deficiency.

• Precautions: This medicine is contraindicated in severe kidney impairment, type 1 diabetes, diabetic ketoacidosis, and conditions like alcoholism or severe heart failure. Caution is advised for patients with liver, kidney, or heart problems, pancreatic issues, or severe infections. Pregnant and breastfeeding individuals should consult their doctor before use. Excessive alcohol consumption should be avoided due to an increased risk of lactic acidosis. Regular monitoring of blood sugar levels and kidney function is crucial during treatment.

• Storage: Store ALSITA M 100 MG TABLET at room temperature, generally between 20°C and 25°C or below 30°C. Keep it protected from light and moisture in a tightly closed container and out of reach of children. Ensure it is used before its expiry date.

What is ALSITA M 100 MGTABLET used for?

ALSITA M 100 MGTABLET is primarily used to treat and manage type 2 diabetes mellitus in adults. It helps to control blood sugar levels when diet and exercise alone are not sufficient. By improving blood sugar control, it helps reduce the risk of long-term complications associated with diabetes, such as kidney damage, blindness, nerve damage, heart attacks, and strokes.

How does ALSITA M 100 MGTABLET work?

This medicine is a combination of two active ingredients: Sitagliptin (100mg) and Metformin (500mg).

• Sitagliptin is a DPP-4 inhibitor. It works by increasing the levels of natural hormones called incretins, which enhance the pancreas's ability to release insulin after a meal and decrease the amount of sugar produced by the liver.
• Metformin is a biguanide. It works by reducing the production of glucose in the liver, delaying the absorption of glucose from the intestines, and improving the body's sensitivity to insulin. Together, these actions help to lower both fasting and post-meal blood sugar levels.

What is the usual dosage of ALSITA M 100 MGTABLET?

The dosage of ALSITA M 100 MGTABLET is determined by your doctor based on your individual condition, blood sugar levels, and response to treatment. It is typically prescribed as one tablet, once or twice daily, and should be taken with meals to minimize gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed or chewed.

What are the possible side effects of ALSITA M 100 MGTABLET?

Common side effects may include upper respiratory tract infection, nasopharyngitis, diarrhea, headache, nausea, vomiting, stomach pain, flatulence, and a metallic taste in the mouth. Low blood sugar (hypoglycemia) can occur, especially if taken with other diabetes medications like insulin or sulfonylureas. Serious, though rare, side effects can include lactic acidosis (a build-up of lactic acid in the body) and pancreatitis (inflammation of the pancreas). Long-term use of metformin can also lead to vitamin B12 deficiency.

Is ALSITA M 100 MGTABLET safe during pregnancy or breastfeeding?

ALSITA M 100 MGTABLET is generally not recommended for use during pregnancy and is considered unsafe as it may produce harmful effects on the fetus. Similarly, it is generally considered unsafe during breastfeeding as it may excrete via breast milk. It is crucial to consult your doctor to discuss the potential risks and benefits if you are pregnant, planning to become pregnant, or breastfeeding.

Can ALSITA M 100 MGTABLET be taken with other medications?

ALSITA M 100 MGTABLET can interact with several other medications.

• Taking it with insulin secretagogues or insulin may increase the risk of hypoglycemia, potentially requiring a dose reduction of those medicines.
• Diuretics (e.g., furosemide) and carbonic anhydrase inhibitors (e.g., acetazolamide) may increase the risk of lactic acidosis.
• Cationic medications (e.g., amiloride, digoxin, ranitidine) may interfere with metformin's absorption or elimination. Always inform your doctor about all other medications, supplements, or herbal products you are currently taking to avoid potential drug interactions.

What precautions should be taken while using ALSITA M 100 MGTABLET?

Several precautions should be observed:

• Kidney and Liver Issues: This medicine is contraindicated in patients with severe renal impairment and should be used with caution in those with kidney or liver problems. Regular monitoring of kidney function is often recommended.
• Alcohol Consumption: Avoid excessive alcohol intake as it can significantly increase the risk of lactic acidosis, a serious side effect of metformin.
• Pancreatitis: Inform your doctor if you have a history of pancreatitis, as sitagliptin has been linked to an increased risk of this condition.
• Heart Conditions: It is not recommended for patients with severe heart problems.
• Dehydration/Infections: Caution is advised if you are severely dehydrated due to excessive vomiting or diarrhea, or have severe systemic infections.
• Surgery: Inform your doctor about your diabetes treatment if you are scheduled for surgery under general anesthetic or any X-rays involving iodine contrast medium. Maintain a healthy diet and regular exercise routine as advised by your doctor to achieve the best results.

What happens if a dose of ALSITA M 100 MGTABLET is missed?

If you miss a dose of ALSITA M 100 MGTABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should ALSITA M 100 MGTABLET be stored?

ALSITA M 100 MGTABLET should be stored at room temperature, typically between 20°C and 25°C. It should be protected from light and moisture and kept in a tightly closed container. Always ensure this medication is kept out of reach of children.