Dabiclot 110 Capsule

Dabiclot 110 Capsule by Alkem Laboratories Ltd. is an anticoagulant medicine, commonly known as a blood thinner, used to prevent and treat blood clots.

Name

• Brand Name: DABICLOT 110 CAPSULE
• Common Name: Dabigatran Etexilate

Composition

Each capsule contains 110 mg of Dabigatran Etexilate (sometimes specified as Dabigatran Etexilate Mesylate). This active ingredient functions by directly inhibiting thrombin, an enzyme crucial for blood clot formation, thereby reducing the conversion of fibrinogen to fibrin and preventing clots.

Uses

Dabiclot 110 Capsule is prescribed for:

• Preventing and treating the risk of stroke and heart attack, especially in patients with atrial fibrillation (irregular heart rhythm).
• Preventing and treating deep vein thrombosis (DVT) and pulmonary embolism (PE).
• Reducing the risk of blood clot formation following knee or hip replacement surgeries.

Dosage and Administration

This medicine should be taken exactly as prescribed by your doctor. It can be taken with or without food, preferably at the same time each day. Swallow the capsule whole with a glass of water; do not chew, break, or open it. Do not stop taking the medication abruptly without consulting your doctor.

Side Effects

Common side effects may include:

• Bleeding (e.g., bruising, nosebleeds)
• Anaemia
• Nausea, stomach pain, dyspepsia (indigestion), abdominal pain, diarrhea, epigastric discomfort, gastroesophageal reflux disease (GERD) symptoms.

Serious side effects, though rare, can include severe bleeding (e.g., gastrointestinal bleeding, intracranial haemorrhage) and allergic reactions. Consult your doctor immediately if you experience severe or persistent side effects.

Precautions

• Bleeding Risk: Dabiclot 110 Capsule increases the risk of bleeding. Inform your doctor about any active bleeding, bleeding disorders, or planned surgeries.
• Kidney/Liver Impairment: Use with caution in patients with kidney or liver problems, as dosage adjustments may be necessary.
• Pregnancy and Breastfeeding: Not recommended for use during pregnancy or breastfeeding unless advised by a doctor.
• Alcohol: Avoid alcohol consumption as it may increase the risk of stomach problems and bleeding.
• Drug Interactions: Inform your doctor about all other medications you are taking, especially other anticoagulants, as interactions can occur.

Storage

Store Dabiclot 110 Capsule in a cool, dry place at 10ºC to 25ºC or below 30ºC, protected from moisture and direct sunlight. Keep out of the sight and reach of children. Once the bottle is opened, it should be used within 4 months.

DABICLOT 110 CAPSULE, containing Dabigatran etexilate, is an anticoagulant medication used to prevent and treat blood clots. This medicine works by thinning the blood, allowing for smoother blood flow and reducing the risk of serious clot-related conditions.

Here are some frequently asked questions about DABICLOT 110 CAPSULE:

What is DABICLOT 110 CAPSULE used for?

DABICLOT 110 CAPSULE is primarily used to prevent and treat blood clots. It helps reduce the risk of stroke and heart attack in individuals with irregular heart rhythms (atrial fibrillation). It is also prescribed to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lungs), and to reduce the risk of clot formation following knee or hip replacement surgeries.

How does DABICLOT 110 CAPSULE work?

This medicine contains Dabigatran etexilate, which is an active ingredient that works by directly inhibiting thrombin, a key enzyme involved in blood clot formation. By blocking thrombin, DABICLOT 110 CAPSULE prevents the conversion of fibrinogen to fibrin, a protein essential for clotting, thereby preventing blood clots and facilitating smooth blood flow through the veins.

What is the usual dosage for DABICLOT 110 CAPSULE?

DABICLOT 110 CAPSULE is typically taken twice daily, at approximately the same time each morning and evening. For specific conditions like after knee or hip replacement surgery, the dosage might involve one 110 mg capsule initially, followed by two capsules once daily for a set duration (e.g., 9 days for knee replacement, 27 days for hip replacement). It should be swallowed whole with a glass of water; do not chew, crush, or open the capsule. It can be taken with or without food. Your doctor will determine the appropriate dose and duration of treatment based on your condition.

What are the possible side effects of DABICLOT 110 CAPSULE?

Common side effects include bleeding (such as bruising, nosebleeds, or stomach bleeding), anemia, nausea, stomach pain, vomiting, indigestion (dyspepsia), abdominal pain, and diarrhea. Less common or more severe side effects can include severe bleeding, allergic reactions (rash, itching, swelling), headaches, seizures, changes in eyesight, fatigue, and potential liver or kidney problems. If you experience persistent or severe side effects, consult your doctor.

Is DABICLOT 110 CAPSULE safe during pregnancy or breastfeeding?

DABICLOT 110 CAPSULE is generally not recommended during pregnancy unless specifically advised by a doctor, and women of childbearing potential should aim to avoid pregnancy while taking this medication. It is also advised to avoid breastfeeding while taking DABICLOT 110 CAPSULE. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can DABICLOT 110 CAPSULE be taken with other medications?

DABICLOT 110 CAPSULE can interact with various medications, potentially increasing the risk of bleeding or affecting its effectiveness. Such medications include other blood thinners (like warfarin, heparin, apixaban, rivaroxaban, aspirin, clopidogrel), non-steroidal anti-inflammatory drugs (NSAIDs like ibuprofen), certain antibiotics (e.g., rifampicin, clarithromycin, azithromycin), antifungals (like ketoconazole), cyclosporine, dronedarone, and certain antiviral medications. It is crucial to inform your doctor about all medicines, supplements, and herbal products you are taking to avoid potential interactions.

What precautions should be taken while using DABICLOT 110 CAPSULE?

Inform your doctor about any pre-existing medical conditions, especially kidney or liver problems, stomach ulcers, high blood pressure, bleeding disorders, or recent surgeries/injuries. Avoid alcohol consumption as it can increase the risk of stomach bleeding. Do not stop taking the medication abruptly without consulting your doctor, as this can significantly increase your risk of blood clots, heart attack, or stroke. Be cautious during activities that might increase your risk of bleeding, such as shaving or contact sports. If you are scheduled for surgery or dental work, inform your healthcare provider that you are taking DABICLOT 110 CAPSULE. It is not recommended for children under 18, patients with severe kidney/liver disease, active bleeding, or mechanical prosthetic heart valves.

What happens if a dose of DABICLOT 110 CAPSULE is missed?

If you miss a dose, take it as soon as you remember on the same day. However, if it is almost time for your next scheduled dose (for example, less than 6 hours away), skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should DABICLOT 110 CAPSULE be stored?

Store DABICLOT 110 CAPSULE in a cool, dry place, away from direct sunlight and moisture, preferably at room temperature between 15°C to 30°C (59°F to 86°F). Keep it out of the sight and reach of children and pets. Once the bottle is opened, the capsules should be used within 4 months, and any unused capsules should be discarded safely after this period.