Encelin M 50/850 Mg Tablet (10 Tab)

ENCELIN M 50/850 MG TABLET

Name: Encelin M 50/850 mg Tablet is the brand name, manufactured by Torrent Pharmaceuticals Ltd.. Its generic name reflects its active ingredients.

Composition: Each tablet contains Vildagliptin 50 mg and Metformin Hydrochloride 850 mg.

Uses: ENCELIN M 50/850 MG TABLET is prescribed for the management of type 2 diabetes mellitus in adults. It is particularly used when diet and exercise alone, or metformin monotherapy, do not adequately control blood sugar levels. It can also be used in combination with other antidiabetic medicines, including insulin, to improve glycemic control. It works by helping the pancreas produce more insulin and less glucagon, and by making the body more sensitive to insulin, thereby lowering blood sugar levels.

Dosage and Administration:

• ENCELIN M 50/850 MG TABLET should be taken orally as directed by a physician.
• It is typically advised to take the tablet twice daily, preferably with meals, to minimize stomach upset.
• The tablet should be swallowed whole with water and not crushed, chewed, or broken.
• The exact dose and duration of treatment are determined by the doctor based on the patient's condition, blood sugar levels, and other medications. Do not stop taking the medicine without consulting your doctor.

Side Effects:

• Common Side Effects: Nausea, vomiting, diarrhea, stomach pain/upset, headache, dizziness, low blood sugar (hypoglycemia, especially when used with insulin or sulfonylureas), loss of appetite, metallic taste, joint pain, tiredness, constipation, and swollen hands, ankles, or feet (oedema).
• Serious Side Effects (Seek immediate medical attention if experienced):
  • Symptoms of lactic acidosis, such as severe and persistent stomach pain, vomiting, decreased heartbeat, difficulty breathing, muscle cramps, general weakness with severe tiredness, or reduced body temperature.
  • Signs of an inflamed pancreas, characterized by severe and persistent pain in the abdomen, with or without nausea or vomiting.

Precautions:

• Contraindications: Do not use if allergic to vildagliptin, metformin, or other ingredients. It is contraindicated in patients with type 1 diabetes, severe kidney disease, severe liver disease, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.
• Pregnancy and Breastfeeding: Not recommended during pregnancy unless specifically advised by a doctor, and generally contraindicated for breastfeeding women.
• Alcohol Consumption: Avoid alcohol intake during treatment as it may increase the risk of lactic acidosis.
• Special Populations: Use with caution in elderly patients (65 years and above). Not suitable for children and adolescents under 18 years of age.
• Monitoring: Regular monitoring of blood sugar levels, kidney function, and liver enzymes is essential during treatment. Prolonged use may require annual thyroid-stimulating hormone (TSH) checks.
• Interactions: Inform your doctor about all other medicines you are taking, including insulin and sulfonylureas, as interactions can occur.
• Other Warnings: May cause dizziness, affecting the ability to drive or operate machinery. A rare but serious skin reaction called bullous pemphigoid may occur.

Storage: Store in a cool and dry place, away from direct sunlight. Typically, keep at or below 30°C (10ºC to 25ºC). Protect from moisture and light. Keep out of the sight and reach of children.

What is ENCELIN M 50/850 MG TABLET used for?

ENCELIN M 50/850 MG TABLET is primarily used to manage Type 2 diabetes mellitus in adults. It is prescribed when diet and exercise alone, or treatment with either metformin or vildagliptin alone, is not sufficient to control blood sugar levels. This medication helps in improving both fasting and after-meal blood glucose levels and can be used alongside other diabetes medicines, including insulin, for better control. Controlling blood sugar levels can help reduce the risk of serious complications such as kidney damage, eye damage, nerve problems, and cardiovascular issues.

How does ENCELIN M 50/850 MG TABLET work?

ENCELIN M 50/850 MG TABLET is a combination of two antidiabetic medicines: Metformin (850 mg) and Vildagliptin (50 mg). Metformin, a biguanide, works by lowering the production of glucose in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin. Vildagliptin, a DPP-4 inhibitor, increases the release of insulin from the pancreas when blood sugar levels are high and decreases the hormones that raise blood sugar levels (glucagon). Together, these components work to provide better control of blood sugar by regulating glucose production, absorption, and insulin utilization.

What is the usual dosage for ENCELIN M 50/850 MG TABLET?

The dosage of ENCELIN M 50/850 MG TABLET will be determined by your doctor based on your medical condition, response to treatment, and other medications you may be taking. It is typically taken orally with a meal to help reduce stomach upset. You should swallow the tablet whole with water and take it regularly at the same time each day for optimal benefit.

What are the possible side effects of ENCELIN M 50/850 MG TABLET?

Common side effects can include nausea, vomiting, diarrhea, stomach pain or discomfort, headache, dizziness, loss of appetite, metallic taste, and low blood sugar (hypoglycemia). Serious but rare side effects include lactic acidosis (symptoms like vomiting, stomach pain, decreased heartbeat, difficulty breathing, muscle cramps, severe tiredness) and signs of an inflamed pancreas (severe and persistent abdominal pain with or without nausea or vomiting). If you experience any severe or persistent side effects, contact your doctor immediately.

Is ENCELIN M 50/850 MG TABLET safe during pregnancy or breastfeeding?

ENCELIN M 50/850 MG TABLET is generally not recommended during pregnancy unless specifically advised by a doctor, as there is limited human data and animal studies have shown potential harmful effects on the developing baby. Similarly, it is probably unsafe to use while breastfeeding, as its components are known to pass into breast milk, and due to limited data on vildagliptin, it is not recommended. Always consult your doctor to discuss the potential risks and benefits.

Can ENCELIN M 50/850 MG TABLET be taken with other medications?

ENCELIN M 50/850 MG TABLET can interact with certain other medications. Inform your doctor about all medicines you are taking. Interactions can occur with:

• ACE inhibitors (e.g., enalapril, lisinopril) which may increase the risk of angioedema or hypoglycemia.
• Iodinated contrast agents used in imaging procedures may require temporary stoppage of Encelin M to prevent kidney problems.
• Antacids (e.g., cimetidine, ranitidine) can increase metformin levels in the blood.
• Glucocorticoids, beta-2-agonists, and diuretics can counteract the blood sugar-lowering effect.
• NSAIDs (e.g., ibuprofen, celecoxib) can interact. It is important to discuss all your current medications with your doctor to ensure safety and avoid potential interactions.

What precautions should be taken while taking ENCELIN M 50/850 MG TABLET?

Several precautions should be observed:

• Kidney and Liver Conditions: This medicine should be used with caution, or is contraindicated, in patients with kidney or liver problems, and kidney/liver function should be monitored before and during treatment.
• Heart Conditions: It is contraindicated in patients with severe heart conditions like congestive heart failure.
• Alcohol Consumption: Avoid consuming alcohol as it significantly increases the risk of lactic acidosis, a serious condition.
• Hypoglycemia: Be aware of symptoms of low blood sugar (dizziness, sweating, hunger) and carry a source of sugar.
• Children and Elderly: It is not recommended for children and adolescents under 18 years. Use with caution in elderly patients (65 years and above) with regular renal monitoring.
• Diabetic Ketoacidosis/Type 1 Diabetes: Not for use in Type 1 diabetes or diabetic ketoacidosis.
• Driving: If you experience dizziness or low blood sugar, avoid driving or operating machinery.

What happens if a dose is missed?

If you miss a dose of ENCELIN M 50/850 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should ENCELIN M 50/850 MG TABLET be stored?

Store ENCELIN M 50/850 MG TABLET in its original container, tightly closed, in a cool and dry place away from direct sunlight. The storage temperature should generally be below 30°C. Keep it out of the sight and reach of children.