Jalra Trio Forte Tab

JALRA TRIO FORTE TAB by US VITAMINS (USV)

Name

Jalra-Trio Forte Tablet (common name), sometimes referred to as Jalra-Trio Forte Tablet SR.

Composition

Jalra-Trio Forte Tablet contains a combination of three active antidiabetic agents:

• Dapagliflozin (10mg): A sodium-glucose cotransporter-2 (SGLT2) inhibitor.
• Vildagliptin (100mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor.
• Metformin (1000mg): A biguanide.

Uses

This medication is primarily used to control high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is prescribed when diet and exercise alone are not sufficient to manage blood sugar.

• Type 2 Diabetes Management: Works by improving insulin sensitivity, reducing glucose production, and increasing glucose excretion through urine.
• Cardiovascular and Renal Protection: Helps reduce the risk of heart failure and kidney complications associated with diabetes, including lowering blood pressure and improving vascular function.
• Weight and Metabolic Control: Supports weight loss and improves metabolic parameters by reducing excess glucose and enhancing insulin response, beneficial for overweight or obese diabetic patients.
• HbA1c Reduction and Glycemic Stability: Effectively lowers HbA1c levels and helps maintain stable blood glucose, reducing the risk of hypoglycemia and long-term complications.

Dosage and Administration

Jalra-Trio Forte Tablet should be taken exactly as prescribed by a doctor.

• It can be taken with or without food, or as advised by a doctor, but some sources suggest taking it with food to reduce gastrointestinal side effects.
• Swallow the tablet whole with a glass of water; do not crush, break, or chew it.
• Do not stop taking the medicine abruptly, as this can increase blood sugar levels and lead to serious complications.

Side Effects

Common side effects include:

• Vomiting
• Nausea
• Abdominal pain
• Headache
• Frequent urination
• Allergic reactions
• Vaginal yeast infection
• Urinary tract infection
• Diarrhea
• Dizziness
• Low blood sugar (hypoglycemia)

Serious side effects can include lactic acidosis, especially in patients with kidney or liver issues, and pancreatitis.

Precautions

• Allergies: Avoid if allergic to dapagliflozin, vildagliptin, metformin, or any other components.
• Pregnancy and Breastfeeding: Not recommended during pregnancy and generally considered unsafe during breastfeeding; consult a doctor.
• Alcohol: Avoid alcohol consumption as it increases the risk of hypoglycemia and lactic acidosis.
• Kidney/Liver Disease: Use with caution in patients with kidney problems, and it is likely unsafe for those with liver disease.
• Children: Not recommended for use in children below 18 years of age.
• Interactions: Inform your doctor about other medications, including herbal supplements, as certain drugs like insulin, sulfonylureas, thiazolidinediones, diuretics, corticosteroids, and some heart medicines may interact.
• Surgery/Procedures: Inform your doctor if you are scheduled for surgery, dental work, or X-ray procedures involving dye, as Metformin may need to be temporarily stopped.
• Vitamin B12 Deficiency: Long-term use may reduce vitamin B12 absorption.

Storage

Store in a cool and dry place away from direct sunlight. Keep out of the sight and reach of children. Do not use past the expiry date.

Jalra Trio Forte Tablet, manufactured by USV (US Vitamns), is a combination medication used in the management of type 2 diabetes mellitus. It contains three active ingredients: Dapagliflozin, Vildagliptin, and Metformin, which work together to help control blood sugar levels.

Here are some frequently asked questions about Jalra Trio Forte Tablet:

What is Jalra Trio Forte Tablet used for?

Jalra Trio Forte Tablet is primarily used to control high blood sugar levels in adults with type 2 diabetes mellitus, especially when diet and exercise alone are not sufficient. It also helps in reducing the risk of heart failure and kidney complications associated with diabetes. Additionally, it may support weight loss and improve metabolic parameters in some patients.

How does Jalra Trio Forte Tablet work?

This medicine combines three different antidiabetic agents:

• Dapagliflozin works by inhibiting sodium-glucose cotransporter 2 (SGLT2) in the kidneys, which causes the body to remove excess sugar through urine.
• Vildagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of natural substances called incretins, which help the pancreas release more insulin when blood sugar is high and signal the liver to produce less sugar.
• Metformin (a biguanide) reduces the amount of glucose produced by the liver, decreases the absorption of glucose from the intestines, and improves the body's sensitivity to insulin.

What is the usual dosage for Jalra Trio Forte Tablet?

The exact dosage of Jalra Trio Forte Tablet is determined by your doctor based on your condition and response to treatment. It is crucial to take the tablet exactly as prescribed, typically with or after meals, and at the same time each day for optimal results. The tablet should be swallowed whole and not crushed, broken, or chewed. Do not change your dosage or stop the medication without consulting your doctor.

What are the possible side effects of Jalra Trio Forte Tablet?

Common side effects may include vomiting, nausea, abdominal pain, headache, frequent urination, and allergic reactions. Other possible side effects are vaginal yeast infection, nasopharyngitis, urinary tract infection, diarrhea, and dizziness. Rarely, more serious side effects such as lactic acidosis (an increase of lactic acid in the body) or pancreatitis can occur. If you experience persistent or worsening side effects, consult your doctor.

Is Jalra Trio Forte Tablet safe during pregnancy or breastfeeding?

Jalra Trio Forte Tablet is generally not recommended for use during pregnancy as limited human data suggest it may be unsafe, and animal studies indicate potential harm to the developing fetus. Similarly, it is not recommended for breastfeeding mothers, as some components may pass into breast milk. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medicine.

Can Jalra Trio Forte Tablet be taken with other medications?

Yes, Jalra Trio Forte Tablet can interact with other medications. It is important to inform your doctor about all current medications, supplements, or herbal products you are taking. For instance:

• Taking it with other diabetic medications like insulin or sulfonylureas may require dosage adjustments to prevent very low blood sugar (hypoglycemia).
• Diuretics (water pills) such as furosemide can increase the risk of dehydration and low blood pressure.
• If you require an iodine-based contrast medium for an X-ray or scan, your doctor may advise you to temporarily stop taking Jalra Trio Forte Tablet.
• Alcohol consumption should be limited or avoided as it can increase the risk of hypoglycemia and a serious condition called lactic acidosis.
• Certain heart medicines (e.g., beta-blockers) can mask the symptoms of hypoglycemia.

What precautions should be taken while using Jalra Trio Forte Tablet?

Several precautions should be observed:

• Inform your doctor if you have kidney or liver problems, heart conditions, a history of lactic acidosis, or are scheduled for surgery or certain X-ray procedures.
• Monitor your blood sugar levels regularly as advised by your doctor.
• Stay well-hydrated, especially due to the dapagliflozin component which increases glucose excretion through urine.
• Practice good hygiene to help prevent fungal infections, particularly in the genital area.
• Avoid or limit alcohol intake.
• If you experience dizziness, avoid driving or operating machinery.
• This medication is not recommended for children below 18 years of age.

What happens if a dose of Jalra Trio Forte Tablet is missed?

If you miss a dose of Jalra Trio Forte Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Jalra Trio Forte Tablet be stored?

Jalra Trio Forte Tablet should be stored in a cool, dry place, protected from direct sunlight and moisture. Keep it out of the sight and reach of children. Do not use the medicine beyond its expiry date.