Nintib 150 Mg Capsule (10 Cap)

NINTIB 150 MG CAPSULE

NINTIB 150 MG CAPSULE by CIPLA LTD. is a medication used in the management of certain chronic lung diseases and specific types of cancer.

Name

• Brand Name: NINTIB 150 MG CAPSULE
• Common Name: Nintedanib

Composition The primary active ingredient in NINTIB 150 MG CAPSULE is Nintedanib (150 mg). It belongs to a class of medicines known as tyrosine kinase inhibitors. Nintedanib works by blocking certain enzymes and growth factors involved in the development of lung fibrosis and the proliferation of cancer cells.

Uses NINTIB 150 MG CAPSULE is prescribed for:

• Idiopathic Pulmonary Fibrosis (IPF), a condition causing scarring and stiffness of the lungs.
• Chronic fibrosing interstitial lung diseases with a progressive phenotype, which are lung conditions that worsen over time.
• Slowing the rate of decline in pulmonary function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD).
• In combination with docetaxel, for the treatment of adult patients with locally advanced, metastatic, or recurrent non-small-cell lung cancer (NSCLC) of adenocarcinoma tumor histology after first-line chemotherapy.

Dosage and Administration The recommended dosage is 150 mg taken orally twice daily, approximately 12 hours apart. It should be taken with food and swallowed whole with liquid. Do not chew or crush the capsules. If a dose is missed, the next dose should be taken at the next scheduled time; do not take a double dose to make up for a missed one. Dosage adjustments may be necessary for patients with mild hepatic impairment or due to adverse reactions.

Side Effects Common side effects include:

• Diarrhea, nausea, vomiting, and abdominal pain.
• Decreased appetite, weight loss, and headache.
• Abnormal liver function tests (liver enzyme elevation) and hypertension.

Serious side effects can include liver problems, an increased risk of bleeding, gastrointestinal perforation, and myocardial infarction.

Precautions

• Liver Function: Liver function tests should be conducted before and regularly during treatment.
• Bleeding Risk: Use with caution in patients with a history of bleeding problems or those taking anticoagulants, as NINTIB can increase the risk of bleeding.
• Pregnancy: NINTIB is not recommended during pregnancy as it can harm the unborn baby. Females of reproductive potential must use highly effective contraception during treatment and for at least 3 months after the last dose.
• Hepatic Impairment: Not recommended for patients with moderate to severe hepatic impairment.
• Drug Interactions: Inform your doctor about all medications, supplements, or herbal products being taken, as many can interact with Nintedanib.

Storage Store NINTIB capsules below 25°C or 30°C. Protect from light and moisture. Keep out of the reach and sight of children.

NINTIB 150 mg Capsule (Nintedanib) is a medication used to treat specific progressive lung diseases and certain types of lung cancer. Below are frequently asked questions about this medicine.

What is NINTIB 150 mg Capsule used for?

NINTIB 150 mg Capsule is primarily used to treat idiopathic pulmonary fibrosis (IPF), a chronic lung disease that causes scarring of the lungs. It is also used for chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype and to slow the rate of decline in lung function in patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD). Additionally, it is used in combination with docetaxel to treat adult patients with locally advanced, metastatic, or recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma tumor histology after first-line chemotherapy.

How does NINTIB 150 mg Capsule work?

NINTIB 150 mg Capsule contains nintedanib, which is a tyrosine kinase inhibitor. It works by blocking the action of certain enzymes called tyrosine kinases that are involved in the development of lung fibrosis (scarring) and the growth and progression of cancer cells. By inhibiting these enzymes, it helps to slow down the scarring process in the lungs and can stop or slow the spread of cancer cells.

What is the usual dosage for NINTIB 150 mg Capsule?

The recommended dosage for NINTIB 150 mg Capsule for idiopathic pulmonary fibrosis, chronic fibrosing interstitial lung diseases, or systemic sclerosis-associated interstitial lung disease is 150 mg twice daily, approximately 12 hours apart. The capsules should be taken with food and swallowed whole with liquid, without chewing or crushing them. Do not exceed the maximum daily dosage of 300 mg. For non-small cell lung cancer, the recommended dose is 200 mg twice daily, administered approximately 12 hours apart, on days 2 to 21 of a standard 21-day docetaxel treatment cycle. Your doctor may adjust your dose based on tolerability and liver function tests.

What are the possible side effects of NINTIB 150 mg Capsule?

Common side effects include diarrhea, nausea, vomiting, abdominal pain, abnormal liver function tests, loss of appetite, headache, and weight loss. More serious side effects can include liver problems, an increased risk of bleeding, and gastrointestinal perforation. If diarrhea, nausea, or vomiting are persistent or severe, or if you experience symptoms like yellowing skin or eyes, dark urine, or severe abdominal pain, contact your doctor immediately.

Is NINTIB 150 mg Capsule safe during pregnancy or breastfeeding?

NINTIB 150 mg Capsule is not recommended during pregnancy as it can harm the unborn baby and cause birth defects. Women who can become pregnant must use highly effective contraception during treatment and for at least three months after stopping the medication. It is also probably unsafe to use while breastfeeding, as it is unknown if the components pass into breast milk and may pose a risk to the breastfed child. Consult your doctor if you are breastfeeding.

Can NINTIB 150 mg Capsule be taken with other medications?

Many other medicines can interact with NINTIB 150 mg Capsule, potentially affecting its effectiveness or increasing the risk of side effects. It is important to inform your doctor about all medications, supplements, and herbal products you are taking. Specifically, caution is advised with blood-thinning medications (anticoagulants), as NINTIB can increase the risk of bleeding. Some anti-infective medicines (e.g., erythromycin, ketoconazole) can increase Nintedanib levels, while certain anti-epileptics (e.g., carbamazepine, phenytoin) and St. John's wort can decrease its effectiveness.

What precautions should be taken when taking NINTIB 150 mg Capsule?

Before starting treatment, your doctor will conduct liver function tests and a pregnancy test for females of reproductive potential. Regular monitoring of liver function tests is recommended during the first three months of treatment and periodically thereafter. Inform your doctor if you have a history of bleeding problems, liver or kidney issues, or have recently had abdominal surgery. It is also recommended to stop smoking during treatment. Diarrhea is a common side effect, and your doctor may advise anti-diarrheal medicine and adequate hydration.

What happens if a dose of NINTIB 150 mg Capsule is missed?

If a dose of NINTIB 150 mg Capsule is missed, you should take your next dose at the regularly scheduled time. Do not take the missed dose or double the dose to make up for it.

How should NINTIB 150 mg Capsule be stored?

NINTIB 150 mg Capsule should be stored below 30°C, protected from light and moisture. Keep it out of the reach and sight of children and pets.