Here is a detailed product description for XILIA TRIO 1 MG TABLET by EMCURE PHARMACEUTICALS LTD.

XILIA TRIO 1 MG TABLET

Name: XILIA TRIO 1 MG TABLET (Commonly referred to as Xilia-Trio 1 Tablet SR)

Composition: XILIA TRIO 1 MG TABLET contains a combination of three active ingredients:

• Glimepiride: 1 mg
• Metformin: 500 mg
• Voglibose: 0.2 mg

Uses: XILIA TRIO 1 MG TABLET is an anti-diabetic medicine primarily used to treat type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and single-agent or dual therapy with two drugs are insufficient to adequately control blood sugar levels. This medication helps manage blood sugar by:

• Increasing the amount of insulin released by the pancreas (Glimepiride).
• Lowering glucose production in the liver, delaying glucose absorption from the intestines, and enhancing the body's response to insulin (Metformin).
• Preventing the breakdown of complex sugars into simple sugars like glucose in the intestine, thereby slowing down sugar absorption after meals (Voglibose).

It also aids in preventing serious complications associated with diabetes, such as kidney damage (diabetic nephropathy), blindness (diabetic retinopathy), nerve damage (diabetic neuropathy), and helps reduce the risk of heart attack or stroke.

Dosage and Administration: XILIA TRIO 1 MG TABLET should be taken orally with or immediately before meals, as directed by a physician. It is important to take it regularly at the same time each day for optimal results. The dosage is determined by the doctor based on individual needs and response to treatment. The tablet should be swallowed whole with a glass of water and not crushed, broken, or chewed. Do not stop taking the medicine abruptly without consulting a doctor.

Side Effects: Common side effects may include:

• Hypoglycaemia (low blood glucose levels), characterized by dizziness, sweating, hunger pangs, dry mouth and skin, headache, and shaking.
• Nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.
• Taste change or metallic taste.
• Headache.
• Upper respiratory symptoms or infection.
• Flatulence.
• Edema (swelling) or blurred vision (less common).

Serious side effects like lactic acidosis (too much lactic acid accumulated in the blood) can occur rarely. Contact a doctor immediately if severe hypoglycemia or signs of lactic acidosis are experienced.

Precautions:

• Inform your doctor if you are allergic to any components of XILIA TRIO 1 MG TABLET, other sulfonylureas, or sulphonamides.
• Not recommended for patients with type 1 diabetes mellitus, diabetic ketoacidosis, or severe kidney or liver disease.
• Use with caution in elderly patients and those with a history of heart disease, pancreatitis, or low vitamin B12 levels.
• Avoid alcohol consumption as it can increase the risk of low blood sugar and lactic acidosis.
• XILIA TRIO 1 MG TABLET is not recommended during pregnancy or breastfeeding.
• Regular monitoring of blood sugar levels, blood cell counts, and liver function is advised.
• Inform your doctor about all medications you are taking, as drug interactions can occur with antibacterials, antifungals, other oral antidiabetics, insulin, anticancer drugs, disopyramide, fenyramidol, NSAIDs, cardiac glycosides, and thyroid medications.

Storage: Store XILIA TRIO 1 MG TABLET in a cool and dry place, away from direct sunlight. It should be stored below 25°C or below 30°C. Keep out of sight and reach of children.

Frequently Asked Questions about XILIA TRIO 1 MG TABLET

What is XILIA TRIO 1 MG TABLET used for?

XILIA TRIO 1 MG TABLET is primarily used to treat type 2 diabetes mellitus in adults. It is prescribed when diet, exercise, and therapy with one or two other anti-diabetic medicines are not enough to adequately control blood sugar levels. It helps manage blood sugar, enhance insulin sensitivity, and prevent serious complications of diabetes like kidney damage, blindness, nerve problems, heart attack, or stroke.

How does XILIA TRIO 1 MG TABLET work?

XILIA TRIO 1 MG TABLET is a combination of three anti-diabetic medications: Glimepiride, Metformin, and Voglibose.

• Glimepiride is a sulfonylurea that works by stimulating the pancreas to release more insulin.
• Metformin is a biguanide that reduces the amount of glucose produced by the liver, delays glucose absorption from the intestines, and improves the body's sensitivity to insulin.
• Voglibose is an alpha-glucosidase inhibitor that slows down the breakdown of complex carbohydrates into simple sugars (like glucose) in the intestine, thereby delaying glucose absorption after meals. Together, these three components work to control blood sugar levels effectively.

What is the usual dosage for XILIA TRIO 1 MG TABLET?

XILIA TRIO 1 MG TABLET should be taken orally with or immediately before meals, as directed by your doctor. It is usually taken once or twice daily. Your doctor will determine the appropriate dosage based on your individual needs and how well your blood sugar levels are controlled. It is important to take it at the same time each day for optimal results.

What are the possible side effects of XILIA TRIO 1 MG TABLET?

Common side effects can include hypoglycemia (low blood glucose levels), nausea, diarrhea, abdominal pain, headache, taste changes, and upper respiratory symptoms. Other potential side effects may include vomiting, dizziness, flatulence, blurred vision, swelling, bone fracture, and loss of appetite. If you experience severe or persistent side effects, you should consult your doctor.

Is XILIA TRIO 1 MG TABLET safe during pregnancy or breastfeeding?

XILIA TRIO 1 MG TABLET is generally not recommended for use during pregnancy as it may cause harm to the developing fetus. It is also not recommended for use in breastfeeding women because the medicine may pass into breast milk and potentially harm the nursing child. Pregnant or breastfeeding women should consult their doctor before taking this medication.

Can XILIA TRIO 1 MG TABLET be taken with other medications?

XILIA TRIO 1 MG TABLET can interact with several other medications. It is crucial to inform your doctor about all medicines you are taking, including over-the-counter drugs and herbal supplements. For example, NSAIDs like ibuprofen can amplify its blood sugar-lowering effect. Certain cardiac glycosides, thyroid medications, some antibacterials, antifungals, other oral antidiabetics, insulin, and anticancer drugs may interact with XILIA TRIO 1 MG TABLET. Alcohol consumption should be avoided as it can increase the risk of low blood sugar and a serious condition called lactic acidosis.

What precautions should be taken with XILIA TRIO 1 MG TABLET?

Do not stop taking XILIA TRIO 1 MG TABLET without consulting your doctor, even if you feel better, as this can cause blood sugar levels to rise and increase the risk of complications. Avoid if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe kidney or liver disease, or a known allergy to any of its components. Caution is advised for patients with heart disease, lung problems, or a history of pancreatitis. Regular monitoring of blood sugar levels, blood cell counts, and liver function is recommended. Prolonged fasting should be avoided, and always carry a source of sugar to manage potential low blood sugar.

What happens if a dose is missed?

If you miss a dose of XILIA TRIO 1 MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

How should XILIA TRIO 1 MG TABLET be stored?

XILIA TRIO 1 MG TABLET should be stored in a cool and dry place, away from direct sunlight. Keep it out of sight and reach of children. The recommended storage temperature is below 25°C or below 30°C. Do not use the medicine if it has reached its expiry date.