Edestar Inj 20ml

EDESTAR INJ 20ML by LUPIN LTD-MIND DIV

Name

• Common Name: Edastar Injection
• Brand Name: EDESTAR INJ 20ML by LUPIN LTD-MIND DIV

Composition

• Active Ingredient: Edaravone (1.5 mg per 20 ml)
• Other Ingredients: This medication contains sodium bisulfite, which can trigger allergic reactions.

Uses

Edastar Injection is primarily used for the treatment of Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease, a progressive neurodegenerative condition affecting nerve cells in the brain and spinal cord. It is also indicated for neurological damage caused by ischemic stroke. The medication works as a free radical scavenger and antioxidant, helping to reduce nerve damage, slow disease progression, and protect brain cells by mitigating oxidative stress.

Dosage and Administration

Edastar Injection is administered as an intravenous (into a vein) injection by a doctor or nurse in a clinical setting or hospital. It should not be self-administered.

• Initial Treatment: Typically given once a day for the first 14 days of a 28-day cycle.
• Subsequent Cycles: After the first cycle, it is usually given once a day for the first 10 days of a 28-day cycle.
• The doctor will determine the frequency of administration based on the patient's response to the medication. It is given when oral administration is not feasible.

Side Effects

• Common Side Effects: Headache, bruising, and walking difficulties (gait disturbance). Injection site reactions such as pain, redness, or swelling may also occur; these are usually temporary.
• Serious Side Effects:
  • Hypersensitivity Reactions: Signs include wheezing, difficulty breathing, shortness of breath, cough, fainting, flushing, itching, rash, hives, swelling of the throat, tongue, or face, throat tightness, or difficulty swallowing.
  • Sulfite Allergic Reactions: May manifest as asthma attacks, red itchy welts, breathing problems, itching, swelling of the lips, tongue, or face, dizziness, wheezing, or fainting.

Precautions

• Allergies: Inform your healthcare provider about any known allergies to Edaravone or other ingredients, especially sodium bisulfite, which can cause severe allergic reactions.
• Pre-existing Conditions:
  • Liver Disease: Use with caution in patients with severe liver disease; liver function monitoring may be necessary.
  • Respiratory Conditions: Patients with existing breathing difficulties may experience worsened respiratory symptoms during infusion.
  • Asthma: Not recommended for asthmatic patients due to sensitivity to sulfites.
  • Drug Allergies: Individuals with a history of drug allergies or adverse reactions should exercise caution.
• Medication Interactions: Disclose all current prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products to your doctor.
• Specific Populations: The safety and efficacy in pediatric populations have not been established. Inform your doctor if you are pregnant, planning to become pregnant, suspect you may be pregnant, or are breastfeeding.
• Monitoring: Monitoring of liver function and blood cell counts is necessary during treatment.

Storage

Store in a cool and dry place away from sunlight. Keep out of the sight and reach of children.

Here are some frequently asked questions about EDESTAR INJ 20ML:

What is Edastar Injection used for?

Edastar Injection is primarily used to treat Amyotrophic Lateral Sclerosis (ALS), a neurological disease. It can also be used to address neurological damage resulting from an ischemic stroke.

How does Edastar Injection work?

Edastar Injection contains Edaravone, an antioxidant. This active ingredient works by helping to slow down the worsening of neurological diseases. It prevents the death of nerve cells, preserves muscle function, and protects brain cells by reducing oxidative stress.

What are the possible side effects of Edastar Injection?

Common side effects may include difficulty walking, bruising, and headache. Some individuals might also experience injection site reactions such as pain, redness, or swelling. More serious, but less common, side effects can include allergic reactions like itching, swelling of the lips, tongue, or face, and breathing problems, which require immediate medical attention.

What serious precautions should be taken with Edastar Injection?

Edastar Injection contains sodium bisulfite, which can cause serious or life-threatening hypersensitivity reactions. Therefore, it is not recommended for individuals with asthma or a sulfite allergy, as it may trigger asthmatic episodes. Patients should inform their doctor about any pre-existing conditions, including heart, kidney, liver problems, nervous system disorders, respiratory disorders, or muscle weakness.

Is Edastar Injection safe during pregnancy or breastfeeding?

It is recommended to consult a doctor if you are pregnant or breastfeeding. Information regarding the use of Edastar Injection during pregnancy is not fully available, and it may be considered unsafe in some cases. Similarly, information about its use during breastfeeding is limited, and its safety has not been established.

Can Edastar Injection be taken with other medications?

Patients should inform their doctor about all medications they are currently taking, including other prescription drugs, over-the-counter medicines, and herbal supplements, to avoid potential interactions. Specific interactions for Edaravone are not extensively detailed, but the presence of sodium bisulfite means it should be avoided by those with sulfite sensitivities or asthma.

What is the usual dosage and administration of Edastar Injection?

Edastar Injection is administered by a healthcare professional. It is not intended for self-administration. The specific dosage will be determined by your doctor based on your medical condition. An overdose is unlikely given its professional administration, but medical attention should be sought for any unusual symptoms.

What happens if a dose of Edastar Injection is missed?

Since Edastar Injection is administered by a healthcare professional in a clinical setting, a missed dose would typically be managed by your medical team. You should contact your doctor or healthcare provider immediately if you miss an appointment for your injection or if you believe a dose has been missed.

How should Edastar Injection be stored?

Edastar Injection should be stored in a cool and dry place, away from direct sunlight, typically between 10ºC to 25ºC or below 30ºC. It should always be kept out of the sight and reach of children.