NOBEGLIZ 60 XR Tablet

NOBEGLIZ 60 XR, manufactured by Mankind Pharma Ltd, is an extended-release oral antidiabetic medication primarily used for managing type 2 diabetes mellitus.

Name

• Brand Name: NOBEGLIZ 60 XR
• Common Name: Gliclazide Extended-Release

Composition Each tablet contains Gliclazide 60 mg, formulated as an extended-release tablet to provide sustained blood sugar control throughout the day. Gliclazide belongs to the sulfonylurea class of drugs, working by stimulating the pancreas to release more insulin and improving the body's sensitivity to insulin.

Uses NOBEGLIZ 60 XR is prescribed for adults with type 2 diabetes mellitus when diet and exercise alone are insufficient to control blood sugar levels. Its benefits include lowering blood sugar, improving insulin sensitivity, and controlling blood sugar levels after meals. It may also be used off-label for the management of insulin resistance in Polycystic Ovary Syndrome (PCOS).

Dosage and Administration The recommended dosage is typically 60 mg taken orally once daily, preferably with breakfast or the first main meal of the day. Tablets should be swallowed whole and not crushed, chewed, or broken to maintain the extended-release mechanism. Consistency in timing is advised. The physician determines the exact dosage based on individual patient needs and response to treatment.

Side Effects Common side effects may include hypoglycemia (low blood sugar), headache, dizziness, nausea, vomiting, diarrhea, abdominal pain, indigestion, constipation, and upper respiratory tract infection. Less common but serious side effects can include lactic acidosis, vitamin B12 deficiency, and liver problems such as fever or yellowing of the skin and whites of the eyes.

Precautions

• Contraindications: Not recommended for type 1 diabetes, diabetic ketoacidosis, severe liver or kidney disease, or in patients with known allergies to gliclazide or other sulfonylureas.
• Pregnancy and Breastfeeding: Contraindicated during pregnancy and breastfeeding.
• Alcohol: Avoid alcohol consumption, as it can significantly increase the risk of hypoglycemia.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products, as interactions can occur with beta-blockers, ACE inhibitors, thiazides, antifungals, and certain antibiotics.
• Monitoring: Regular monitoring of blood glucose levels is crucial. Patients should carry a source of fast-acting sugar to treat hypoglycemia.
• G6PD Deficiency: Use with caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of hemolytic anemia.

Storage Store NOBEGLIZ 60 XR tablets at room temperature, below 25°C or 30°C, away from moisture and heat, and out of the reach of children. Always check the expiration date.

Frequently Asked Questions about NOBEGLIZ 60 XR

What is NOBEGLIZ 60 XR used for?

NOBEGLIZ 60 XR is primarily used to manage and control blood sugar levels in adults with Type 2 Diabetes Mellitus. It is prescribed when diet and exercise alone are insufficient to control blood sugar levels. It can also improve insulin sensitivity and help control blood sugar levels after meals. In some cases, it may be used off-label for the management of insulin resistance in Polycystic Ovary Syndrome (PCOS).

How does NOBEGLIZ 60 XR work?

NOBEGLIZ 60 XR contains Gliclazide, which belongs to a class of medicines called sulfonylureas. It works by stimulating the beta cells in the pancreas to release more insulin. Insulin is a hormone that helps glucose (sugar) from the blood enter cells, where it can be used for energy. By increasing insulin secretion, NOBEGLIZ 60 XR helps lower blood glucose levels. The extended-release formulation ensures a gradual and sustained release of the medication, providing prolonged blood sugar control.

What is the usual dosage for NOBEGLIZ 60 XR?

The recommended dosage of NOBEGLIZ 60 XR is determined by your physician based on individual patient needs, disease severity, and response to treatment. Typically, the starting dose is 60mg taken orally once daily. The tablet should be swallowed whole with a glass of water, usually with breakfast or the first main meal of the day, and should not be crushed, chewed, or broken.

What are the possible side effects of NOBEGLIZ 60 XR?

Common side effects of NOBEGLIZ 60 XR may include nausea, vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, headache, dizziness, weakness, and upper respiratory tract infection. Hypoglycemia (low blood sugar) is also a possible side effect, which can manifest as shakiness, sweating, dizziness, and confusion. Less common but more serious side effects can include lactic acidosis, vitamin B12 deficiency, and liver problems. Consult your doctor if you experience any persistent or worsening side effects.

Is NOBEGLIZ 60 XR safe during pregnancy or breastfeeding?

NOBEGLIZ 60 XR is generally not recommended for use during pregnancy as it may be unsafe and animal studies have shown harmful effects on the developing baby. If you are pregnant or planning a pregnancy, consult your doctor for alternative treatments. It is also considered unsafe to use NOBEGLIZ 60 XR while breastfeeding as it is not known whether gliclazide passes into breast milk and data suggests it might cause toxicity to the baby.

Can NOBEGLIZ 60 XR be taken with other medications?

NOBEGLIZ 60 XR can interact with other medications, affecting its efficacy or increasing the risk of side effects. It's crucial to inform your doctor about all other medications, supplements, and herbal products you are taking. Some medications that can interact include beta-blockers, ACE inhibitors, thiazide diuretics, corticosteroids, antifungal medications (like miconazole), and cholesterol-lowering medicines.

What precautions should be taken with NOBEGLIZ 60 XR?

Precautions while taking NOBEGLIZ 60 XR include regularly monitoring blood glucose levels. Be aware of symptoms of low blood sugar (hypoglycemia) and carry a source of fast-acting sugar. Avoid or be cautious with alcohol consumption, as it can increase the risk of low blood sugar. Inform your doctor if you have kidney or liver problems, as dose adjustments may be necessary. It is not recommended for Type 1 diabetes, diabetic pre-coma or coma, or severe liver or kidney disease.

What happens if a dose of NOBEGLIZ 60 XR is missed?

If you miss a dose of NOBEGLIZ 60 XR, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should NOBEGLIZ 60 XR be stored?

NOBEGLIZ 60 XR should be stored at room temperature, below 25°C or 30°C, away from moisture and heat, and protected from light. Keep it out of reach of children. Always check the expiration date before taking the medication, and dispose of any expired or unused medication properly according to local regulations.