Altacef Suspension

ALTACEF SUSPENSION by GLENMARK PHARMACEUTICALS

Altacef Suspension is an oral antibiotic primarily prescribed for managing various bacterial infections. It is a second-generation cephalosporin antibiotic.

Name

• Brand Name: Altacef Suspension
• Common Name: Cefuroxime (active ingredient)

Composition

• Active Ingredient: Cefuroxime (125 mg)

Uses

Altacef Suspension is used to treat a wide range of bacterial infections, particularly in children. These include:

• Respiratory Tract Infections: Upper respiratory tract infections such as pharyngitis, tonsillitis, sinusitis, and otitis media, as well as lower respiratory tract infections like bronchitis and pneumonia.
• Urinary Tract Infections (UTIs): Uncomplicated UTIs.
• Skin and Soft Tissue Infections: Uncomplicated infections of the skin and soft tissues.
• Lyme Disease: Early stages of Lyme disease.
• Prophylactic Use: Prevention of infection after animal or human bites, and before certain surgical procedures to prevent postoperative infection.

Dosage and Administration

Altacef Suspension should be administered as directed by a doctor.

• Shake the bottle well before each use.
• Measure the exact quantity using a measuring spoon or cup.
• It can be given with or without food, but taking it with meals can enhance absorption and reduce the chances of stomach upset.
• The dosage and duration depend on the type and severity of the infection and should not be exceeded without consulting a doctor.
• It is crucial to complete the entire course of treatment even if symptoms improve to prevent antibiotic resistance.

Side Effects

Common Side Effects:

• Diarrhoea
• Nausea
• Vomiting
• Abdominal pain
• Headache
• Dizziness
• Rash or hives (allergic reaction)
• Transient elevation of liver enzymes
• Unpleasant taste in the mouth

Serious Side Effects (less common but require medical attention):

• Persistent vomiting
• Kidney damage
• Severe allergic reactions (e.g., difficulty breathing, swelling of face or mouth)
• Severe, persistent diarrhoea or bloody/mucus in stools (may indicate Clostridioides difficile-associated diarrhoea)
• Pseudomembranous colitis
• Seizures, confusion, tremors, irregular heartbeats

Precautions

• Allergies: Do not use if allergic to cefuroxime, any other cephalosporin antibiotics, or if there's a history of severe allergic reaction to penicillin, monobactams, or carbapenems.
• Kidney Disease: Use with caution in patients with kidney problems; dosage adjustments may be necessary.
• Antacids: Avoid taking antacids containing magnesium or aluminum close to Altacef Suspension, as they can affect absorption.
• Other Medications: Inform your doctor about all other medicines, supplements, or herbal products being taken to avoid potential interactions, especially with anticoagulants (e.g., warfarin), probenecid, and oral contraceptives.
• Pregnancy and Breastfeeding: Consult a doctor. It is generally considered safe if prescribed during pregnancy, but caution is advised in early pregnancy. Cefuroxime passes into breast milk in low levels, and babies should be observed for symptoms like diarrhoea and yeast infection.
• Lab Tests: Inform laboratory personnel about the use of this medicine, as it may interfere with certain lab tests.
• Antibiotic Resistance: Complete the full course of treatment as prescribed to prevent antibiotic resistance.

Storage

• Store Altacef Suspension below 30°C, in a cool and dry place.
• Protect it from direct sunlight, heat, and moisture.
• Keep it out of the reach of children.
• Once reconstituted, store in a refrigerator and use within 7 days.

Here are frequently asked questions about ALTACEF SUSPENSION by GLENMARK PHARMACEUTICALS:

What is ALTACEF SUSPENSION used for?

ALTACEF SUSPENSION is an antibiotic containing Cefuroxime, a second-generation cephalosporin, used to treat a wide range of bacterial infections. These include upper and lower respiratory tract infections (like tonsillitis, pharyngitis, sinusitis, otitis media, bronchitis, and pneumonia), urinary tract infections (UTIs), skin and soft tissue infections, and early Lyme disease. It may also be used to prevent infections before certain surgical procedures.

How does ALTACEF SUSPENSION work?

ALTACEF SUSPENSION works by killing bacteria. Its active ingredient, Cefuroxime, is a bactericidal antibiotic that interferes with bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs) in the bacterial cell wall, which are crucial for the construction and maintenance of the cell wall. By inhibiting these enzymes, Cefuroxime prevents the bacteria from forming a stable cell wall, leading to cell lysis and death of the bacteria.

What is the usual dosage for ALTACEF SUSPENSION?

The dosage of ALTACEF SUSPENSION depends on the type and severity of the infection, and the patient's age and weight. It is typically taken twice daily, usually every 12 hours. It is recommended to take it with food to improve absorption and reduce stomach upset. For children, typical dosages can range from 10 mg/kg to 15 mg/kg twice daily, with maximum daily doses varying by age and condition. It should not be used in infants younger than 3 months of age. Always follow your doctor's instructions regarding dosage and duration.

What are the possible side effects of ALTACEF SUSPENSION?

Common side effects of ALTACEF SUSPENSION may include gastrointestinal issues such as diarrhea, nausea, vomiting, and abdominal pain. Other common side effects can include headache, dizziness, and mild skin rash. Serious side effects, though rare, can include severe allergic reactions (e.g., hives, swelling of face/lips/tongue, difficulty breathing), persistent severe diarrhea (which could be a sign of Clostridioides difficile-associated diarrhea), and transient elevation of liver enzymes.

Is ALTACEF SUSPENSION safe during pregnancy or breastfeeding?

During pregnancy, ALTACEF SUSPENSION is generally considered safe if prescribed by a doctor. However, pregnant women should consult their doctor before using it. If used during breastfeeding, caution should be exercised as it is excreted in human milk. The baby should be observed for symptoms such as diarrhea and yeast infection. It is advisable to consult a doctor before taking this medicine while breastfeeding.

Can ALTACEF SUSPENSION be taken with other medications?

ALTACEF SUSPENSION can interact with certain medications. For example, antacids containing magnesium or aluminum may affect its absorption and should be avoided or taken at least 1-2 hours apart. Probenecid can increase the levels of Cefuroxime in the body, and co-administration is generally not recommended. It may also interact with oral contraceptives, potentially lowering their effectiveness, so alternative birth control methods or precautions might be necessary. Blood thinners like warfarin may also interact, potentially altering their effect. Always inform your doctor about all medications, supplements, and herbal products you are currently taking.

What precautions should be taken while using ALTACEF SUSPENSION?

Before taking ALTACEF SUSPENSION, inform your doctor about any allergies, especially to cephalosporins or penicillins, due to the risk of cross-sensitivity. Patients with kidney disease should use this medication with caution, as dosage adjustments may be necessary. It's crucial to complete the full course of treatment as prescribed, even if symptoms improve, to prevent antibiotic resistance. If severe, persistent diarrhea occurs, or if you experience any signs of an allergic reaction (like rash, swelling, or difficulty breathing), seek immediate medical attention. Avoid alcohol consumption as it can cause dehydration and affect sleep.

What happens if a dose of ALTACEF SUSPENSION is missed?

If you miss a dose of ALTACEF SUSPENSION, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ALTACEF SUSPENSION be stored?

ALTACEF SUSPENSION should be stored in a cool and dry place, away from direct sunlight, at temperatures typically between 10ºC to 25ºC or below 30ºC. After reconstitution, the suspension should be stored in a refrigerator and used within 7 to 10 days, depending on specific product instructions. Always keep it out of sight and reach of children.