Espin Tm

ESPIN TM Tablet

ESPIN TM Tablet, manufactured by Intas Pharmaceuticals Ltd., is a combination medication primarily prescribed for the management of hypertension, commonly known as high blood pressure. This medicine works to relax blood vessels, thereby improving blood flow and making the heart more efficient at pumping blood throughout the body.

Composition

ESPIN TM Tablet contains a combination of two active ingredients:

• S-Amlodipine (2.5 mg): A calcium channel blocker that dilates blood vessels and increases blood flow.
• Telmisartan (40 mg): An angiotensin II receptor antagonist that lowers blood pressure by preventing blood vessel narrowing.

Uses

ESPIN TM Tablet is used to treat:

• Hypertension (High Blood Pressure): It effectively lowers high blood pressure, reducing the risk of serious cardiovascular events.
• Prevention of Cardiovascular Events: By managing blood pressure, it helps to lower the chances of stroke, heart attack, and kidney problems.
• Chest Pain (Angina): It can also be used to manage chest pain (angina) and other conditions caused by coronary artery disease.

Dosage and Administration

• ESPIN TM Tablet should be taken exactly as prescribed by your doctor, usually once daily.
• It can be taken with or without food.
• To maintain consistent medication levels, it is recommended to take it at the same time each day.
• Swallow the tablet whole with water; do not chew, crush, or break it.
• Do not stop taking the medication abruptly without consulting your doctor, as this may worsen your condition or cause symptoms to recur.

Side Effects

Common Side Effects:

• Dizziness, headache, fatigue, sleepiness
• Nausea, stomach pain, constipation, diarrhea, taste changes
• Ankle swelling (oedema), muscle cramps, numbness in extremities
• Low blood pressure (hypotension), increased potassium levels in blood
• Flushing (sense of warmth), palpitations, blurred vision

Serious Side Effects (seek immediate medical attention):

• Severe chest pain or irregular heartbeat
• Signs of allergic reaction (e.g., swelling of the face, lips, throat, difficulty breathing, severe skin rash with itching, blistering)
• Yellowing of eyes or skin (liver problems)
• Pancreatitis (intense stomach pain radiating to the back)

Precautions

• Allergies: Do not take if you are allergic to ESPIN TM or any of its ingredients.
• Pregnancy and Breastfeeding: ESPIN TM is not recommended during pregnancy as it can harm the developing fetus. It is also not recommended for breastfeeding women. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Liver and Kidney Disease: Use with caution in patients with liver or kidney problems. Dosage adjustments may be necessary for liver disease, and it's not advised for severe liver disease. Monitoring of kidney function and electrolyte levels is recommended.
• Low Blood Pressure: Use with caution, especially if you have low blood pressure, are dehydrated, or have low sodium levels.
• Potassium Levels: Avoid potassium supplements and foods rich in potassium (e.g., bananas, coconut water, broccoli) as it may lead to high potassium levels in the blood.
• Alcohol Consumption: Avoid alcohol as it can worsen dizziness and drowsiness.
• Driving and Machinery: This medicine may cause dizziness, headaches, or tiredness, affecting your ability to concentrate. Exercise caution when driving or operating machinery.
• Grapefruit: Avoid consuming grapefruit or grapefruit juice, as it can increase the medication's effects and risk of side effects.
• Drug Interactions: Inform your doctor about all other medications, including over-the-counter drugs and supplements, as ESPIN TM can interact with other blood pressure medicines, NSAIDs, and Aliskiren.
• Diabetes: If you have diabetes, your blood sugar levels may need to be monitored closely.
• Children: ESPIN TM is not recommended for use in individuals under 18 years of age.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep the medicine out of sight and reach of children.
• Store below 25°C or at room temperature (between 10ºC to 25ºC or below 30ºC).
• Protect from moisture.

What is ESPIN TM Tablet used for?

ESPIN TM Tablet is a combination medicine primarily used to treat hypertension (high blood pressure). Lowering blood pressure helps to reduce the risk of serious cardiovascular events such as stroke, heart attack, and kidney damage. It can also be used to manage heart-related chest pain (angina).

How does ESPIN TM Tablet work?

ESPIN TM Tablet combines two active ingredients: S-Amlodipine and Telmisartan. S-Amlodipine is a calcium channel blocker (CCB), and Telmisartan is an angiotensin receptor blocker (ARB). These work together by relaxing and widening the blood vessels, which allows blood to flow more easily and makes the heart more efficient at pumping blood throughout the body, thereby lowering blood pressure.

What is the usual dosage for ESPIN TM Tablet?

ESPIN TM Tablet should be taken exactly as prescribed by your doctor. It is typically taken once daily, with or without food. It is recommended to take it at the same time each day to maintain consistent medication levels in your body. Do not chew, crush, or break the tablet.

What are the possible side effects of ESPIN TM Tablet?

Common side effects include nausea, taste changes, ankle swelling, headache, dizziness, numbness of extremities, flushing (sense of warmth), increased potassium levels, decreased blood pressure, sleepiness, palpitations, fatigue, back pain, diarrhea, and stomach pain. Seek immediate medical attention if you experience serious side effects such as severe chest pain, irregular heartbeat, swelling of the face or throat (allergic reaction), yellowing of eyes or skin (liver problems), or sudden difficulty breathing.

Is ESPIN TM Tablet safe during pregnancy or breastfeeding?

ESPIN TM Tablet is generally considered unsafe during pregnancy as there is definite evidence of risk to the developing baby, potentially causing serious harm or even death. If you become pregnant or are planning to conceive, stop taking it immediately and consult your doctor. It is also probably unsafe to use during breastfeeding, and a doctor should be consulted for advice.

Can ESPIN TM Tablet be taken with other medications?

ESPIN TM Tablet can interact with various medications. Inform your doctor about all other medicines you are taking, especially other blood pressure medications (e.g., aliskiren, ACE inhibitors), potassium supplements or potassium-sparing diuretics, non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, lithium, or St. John's wort. Avoid consuming grapefruit products as they may increase the medication's effects.

What precautions should be taken while using ESPIN TM Tablet?

Avoid consuming alcohol, as it can worsen dizziness and drowsiness. Do not drive or operate heavy machinery if you experience dizziness or sleepiness. If you have kidney or liver problems, heart conditions (like congestive heart failure), or low blood pressure, inform your doctor. Avoid potassium-rich foods and supplements, as the medicine can increase potassium levels. Do not stop taking ESPIN TM Tablet without consulting your doctor, as abrupt discontinuation can worsen your condition. Regular monitoring of blood pressure, kidney function, and electrolyte levels may be necessary.

What happens if a dose of ESPIN TM Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.