Pletoz 100mg Tablet

PLETOZ 100MG TABLET

PLETOZ 100MG TABLET is a medication manufactured by Cipla Ltd., primarily prescribed to alleviate the symptoms of intermittent claudication.

Composition Each tablet of PLETOZ 100MG contains Cilostazol 100mg as its active ingredient. Cilostazol is classified as a phosphodiesterase type 3 inhibitor, acting as an antiplatelet drug and a vasodilator.

Uses PLETOZ 100MG TABLET is indicated for the reduction of symptoms associated with intermittent claudication. This condition is characterized by pain, cramping, numbness, or weakness in the legs that occurs during walking or exercise and is relieved by rest, due to insufficient blood flow to the lower limbs. The medicine works by widening blood vessels and reducing the stickiness of platelets, thereby improving blood circulation in the legs and increasing walking distance without pain.

Dosage and Administration The recommended dosage for PLETOZ is 100 mg twice daily (b.i.d.). It should be taken orally, at least 30 minutes before or two hours after breakfast and dinner, on an empty stomach, to ensure optimal absorption. Tablets should be swallowed whole with a glass of water and not crushed, chewed, or broken. Patients may experience a beneficial effect within 2 to 4 weeks, though up to 12 weeks of treatment may be needed for full effect.

Side Effects Common side effects include headache, dizziness, diarrhea, abnormal stool, palpitations, nausea, vomiting, abdominal pain, loss of appetite, and rashes. More serious side effects, such as bleeding problems (e.g., nosebleeds, heavier periods, easy bruising, blood in vomit, urine, or stool), chest pain, or edema (swelling), may occur and require medical attention.

Precautions PLETOZ 100MG TABLET is contraindicated in individuals with allergies to cilostazol or its components, heart failure (of any severity), a history of heart attack or abnormal heart rhythm within the last six months, and conditions that increase the risk of bleeding (e.g., stomach ulcers, recent stroke, eye problems with diabetes). It is not recommended for use in pregnant or breastfeeding women. Caution is advised when driving or operating machinery, as the medicine may cause dizziness or drowsiness. Patients should inform their doctor about all existing medical conditions, especially liver or kidney disease, and all other medications, including herbal supplements, to avoid potential drug interactions. Concomitant use with other blood thinners (like Aspirin or Clopidogrel), CYP3A4 inhibitors (e.g., ketoconazole, erythromycin), CYP2C19 inhibitors (e.g., omeprazole), and grapefruit juice should be avoided or managed with dose adjustments. This medicine is not recommended for children under 18 years of age.

Storage Store PLETOZ 100MG TABLET below 30°C in its original packaging. Keep the medicine in a cool, dry place, away from direct sunlight, heat, and moisture, and out of the sight and reach of children and pets.

What is PLETOZ 100MG TABLET used for?

PLETOZ 100MG TABLET, which contains the active ingredient Cilostazol, is primarily used to treat intermittent claudication. This is a condition characterized by cramp-like pain, aching, numbness, or fatigue in the legs (often in the calves, thighs, buttocks, hips, or feet) that occurs during physical activity like walking and is relieved by rest. It helps improve blood flow to the legs, allowing individuals to walk longer distances without discomfort.

How does PLETOZ 100MG TABLET work?

PLETOZ 100MG TABLET works by widening blood vessels and reducing the stickiness of platelets in the blood. This dual action improves blood flow and circulation to the lower limbs. It specifically inhibits the enzyme phosphodiesterase type 3 in the body, which helps to increase blood flow and prevent the formation of harmful blood clots.

What is the usual dosage for PLETOZ 100MG TABLET?

The usual recommended dosage for adults is 100 mg twice daily. It should be taken at least half an hour before or two hours after breakfast and dinner, on an empty stomach, to maximize its effectiveness. While some patients may notice improvement in symptoms within 2 to 4 weeks, the full beneficial effect might take up to 12 weeks of treatment.

What are the possible side effects of PLETOZ 100MG TABLET?

Common side effects can include headache, dizziness, diarrhea, abnormal stools, nausea, vomiting, palpitations, abdominal pain, indigestion, flatulence, rashes, and swelling in the body (edema). More serious, though less common, side effects may include bleeding disorders, increased heart rate, gastritis, fainting, insomnia, increased blood sugar levels, or shortness of breath. If any side effects persist or worsen, or if you notice symptoms like easy bruising, pinpoint rashes, or blood in vomit, urine, or stool, you should consult your doctor immediately.

Is PLETOZ 100MG TABLET safe during pregnancy or breastfeeding?

PLETOZ 100MG TABLET is generally not recommended for use during pregnancy or while breastfeeding. Limited information is available regarding its use in pregnant women, and the components of the medicine may pass into breastmilk, potentially harming the baby. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medication.

Can PLETOZ 100MG TABLET be taken with other medications?

Caution is advised when taking PLETOZ 100MG TABLET with certain other medications. It should not be used with other blood-thinning medications like aspirin or clopidogrel, as this may increase the risk of bleeding. Concomitant use with other blood pressure-lowering medications can also lead to a significant drop in blood pressure. Medicines that inhibit certain enzymes (CYP3A4, such as ketoconazole, erythromycin, diltiazem, or CYP2C19, such as omeprazole) can increase the levels of cilostazol in the body, potentially increasing side effects. Always inform your doctor about all medications, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken while using PLETOZ 100MG TABLET?

Avoid PLETOZ 100MG TABLET if you are allergic to cilostazol or have severe kidney or liver problems, heart conditions such as heart failure, recent heart attack, abnormal heart rhythm, or uncontrolled blood pressure. It is also contraindicated if you have conditions that increase the risk of bleeding, like stomach ulcers, a history of stroke within the last six months, or certain eye problems associated with diabetes. You should avoid smoking and consuming alcohol, as these can worsen your condition and increase side effects. As the medicine may cause dizziness, headache, or tiredness, avoid driving or operating heavy machinery until you know how it affects you. This medicine is not suitable for children and adolescents under 18 years of age. Inform your doctor if you need any surgery, including dental procedures, during the treatment.

What happens if a dose of PLETOZ 100MG TABLET is missed?

If you miss a dose of PLETOZ 100MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should PLETOZ 100MG TABLET be stored?

PLETOZ 100MG TABLET should be stored at room temperature, below 25°C or 30°C, in a cool and dry place. Keep it out of the sight and reach of children and pets.