Exzilor

EXZILOR

Name

• Brand Name: Exzilor, Exzilor Tablet, Exzilor 0.5mg/10mg Tablet.
• Manufacturer: Sun Pharmaceutical Industries Ltd..

Composition

Exzilor contains a combination of two active ingredients:

• Flupenthixol (0.5 mg)
• Melitracen (10 mg)

Uses

Exzilor is prescribed for the management of various mood disorders and related conditions. It works by balancing certain natural substances (chemical messengers) in the brain that influence mood.

• Anxiety
• Depression (including psychogenic depression, depressive neuroses, masked depression, menopausal depressions, and depression in alcoholics and drug addicts)
• Asthenia (weakness)
• Apathy
• Psychosomatic affections accompanied by anxiety and apathy

Dosage and Administration

• Adults: Typically, 2 tablets orally daily, taken in the morning and at noon. In severe cases, the morning dose may be increased to 2 tablets.
• Elderly Patients: Usually 1 tablet in the morning.
• Maintenance Dose: Generally 1 tablet orally in the morning.
• The tablet can be taken with or without food. It is recommended to take it at the same time each day to maintain consistent medication levels in the body. Do not chew, crush, or break the tablet; swallow it whole with water. Do not stop taking this medicine suddenly, as it may cause withdrawal symptoms.

Side Effects

Common Side Effects:

• Restlessness
• Insomnia/Sleeplessness
• Drowsiness/Sleepiness
• Dizziness
• Dry mouth
• Constipation
• Urinary retention
• Blurred vision
• Increased heart rate
• Muscle rigidity/stiffness
• Tremors
• Weight gain
• Agitation

Serious Side Effects:

• Suicidal behavior or thoughts
• Neuroleptic Malignant Syndrome (NMS) characterized by increased heart rate, increased breathing rate, fever, and changes in mood or behavior

Precautions

• Alcohol: Consumption of alcohol is unsafe and not recommended, as it may increase the risk of severe adverse effects such as extreme drowsiness, confusion, and blurred vision.
• Pregnancy and Lactation: Generally not recommended during pregnancy or breastfeeding unless specifically advised by a doctor, as it may pose risks to the unborn baby or pass into breast milk.
• Driving and Operating Machinery: Exzilor may cause drowsiness, dizziness, or affect vision. Avoid driving or operating heavy machinery until you know how the medicine affects you.
• Underlying Conditions: Use with caution and inform your doctor if you have kidney disease, liver disease, thyroid disorder, severe heart disease (including a history of myocardial infarction or bundle-branch conduction defects), epilepsy, Parkinson's disease, glaucoma (untreated narrow-angle), or diabetes.
• Drug Interactions:
  • May enhance the effects of alcohol, barbiturates, and other CNS depressants.
  • Should not be given to patients who have received an MAO-inhibitor within two weeks due to the risk of hypertensive crises.
  • May reduce the antihypertensive effect of guanethidine and similar compounds.
  • May enhance the effects of adrenaline and noradrenaline.
  • Interactions are possible with sedatives, antihistamines, and certain antidepressants.
  • Avoid consuming grapefruit or grapefruit juice.
• Other Warnings: Not recommended for excitable or overactive patients. Not recommended for use in children and adolescents below 18 years of age. Monitor blood sugar levels regularly.

Storage

Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children and pets.

EXZILOR by SUN - SIRIUS is a combination medicine containing Flupenthixol and Melitracen, used to manage various mood disorders, including anxiety, depression, and asthenia (weakness). Flupenthixol is a typical antipsychotic that works by blocking dopamine action, while Melitracen is a tricyclic antidepressant that increases the levels of chemical messengers in the brain responsible for mood regulation.

Here are some frequently asked questions about EXZILOR:

What is EXZILOR used for?

EXZILOR is primarily used for the treatment of depression, anxiety, and asthenia (weakness). It also helps in managing neurasthenia, psychogenic depression, masked depression, menopausal depression, dysphoria, and depression in individuals with alcoholism or drug addiction, as well as psychosomatic conditions accompanied by anxiety and apathy with depressive neuroses.

How does EXZILOR work?

EXZILOR combines two active ingredients: Flupenthixol and Melitracen. Flupenthixol acts as a typical antipsychotic by blocking the action of dopamine, a chemical messenger in the brain that influences thoughts and mood. Melitracen is a tricyclic antidepressant that increases the levels of certain chemical messengers in the brain, helping to regulate mood and alleviate depression. This combined action helps to improve mood, reduce anxiety and tension, enhance sleep, and increase energy levels.

What is the usual dosage for EXZILOR?

For adults, the usual dosage is two tablets daily, typically taken in the morning and at noon. In severe cases, the morning dose may be increased to two tablets. Elderly patients usually take one tablet in the morning. It is crucial to strictly follow the dosage instructions provided by your healthcare professional, as the recommended dose can vary based on your condition and response to the medication.

What are the possible side effects of EXZILOR?

Common side effects of EXZILOR may include drowsiness, changes in weight, restlessness, shakiness, dry mouth, constipation, urinary retention, blurred vision, increased heart rate, muscle stiffness, and tremors. Less common but potentially serious side effects can include hallucinations, migraine-like headaches, decreased interest in sexual intercourse, orthostatic hypotension (sudden drop in blood pressure upon standing), and increased prolactin levels in the blood. In some instances, nausea, vomiting, diarrhea, or abdominal pain may occur. You should contact your doctor immediately if you experience any severe side effects, such as suicidal thoughts or unusual changes in behavior.

Is EXZILOR safe during pregnancy or breastfeeding?

EXZILOR is generally not recommended for use in pregnant women unless absolutely necessary, and only after a thorough discussion with a doctor about the potential risks and benefits. Similarly, it is not recommended for use in breastfeeding women unless absolutely essential, as the medicine can pass into breast milk. If used while breastfeeding, the infant should be closely monitored for any undesirable side effects.

Can EXZILOR be taken with other medications?

EXZILOR can interact with several other medications. It is contraindicated with monoamine oxidase inhibitors (MAOIs) due to the risk of "serotonin syndrome." Concomitant use with MAOIs may cause agitation, confusion, tremor, and hyperthermia. It may enhance the effects of alcohol, barbiturates, and other CNS depressants. EXZILOR can also interact with sympathomimetic agents (like those in nasal decongestants), adrenergic neuron blockers (which reduce antihypertensive effects), and anticholinergic agents. Caution is advised with lithium due to increased neurotoxicity risk, and with levodopa, as EXZILOR may reduce its effect. It is important to inform your doctor about all other medications, supplements, and herbal remedies you are currently taking.

What precautions should be taken while taking EXZILOR?

Do not stop taking EXZILOR suddenly, as this can lead to withdrawal symptoms; gradual dose reduction under medical supervision is recommended. Exercise caution if you have a history of cardiovascular diseases, diabetes, Parkinson's disease, kidney disease, liver disease, thyroid disorder, epilepsy, or glaucoma. Avoid consuming alcohol, as it can increase the risk of severe adverse effects like extreme drowsiness and confusion. This medicine may cause dizziness or sleepiness, so avoid driving or operating heavy machinery until you know how it affects you.

What happens if a dose of EXZILOR is missed?

If you miss a dose of EXZILOR, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one, as this may increase the risk of side effects.

How should EXZILOR be stored?

EXZILOR should be stored at room temperature, ideally not exceeding 30°C. Keep it in a dry place, away from direct sunlight and moisture. It is important to keep the medicine out of reach of children and pets. Always check the expiration date and properly dispose of any expired medication according to local guidelines.