Calutide 50 Mg Tablet (10 Tab)

CALUTIDE 50 MG TABLET by CIPLA LTD.

Name

• Brand Name: CALUTIDE 50 MG TABLET
• Common Name: Bicalutamide (active ingredient)

Composition

Each tablet contains Bicalutamide 50 mg as the active pharmaceutical ingredient.

Uses

CALUTIDE 50 MG TABLET is primarily used for the management of advanced prostate cancer in adult men. It may be prescribed alone or in combination with other therapies, such as LHRH (luteinising hormone-releasing hormone) agonists (e.g., goserelin or leuprolide) or radiation therapy, to slow the growth and spread of prostate cancer cells. The medication works by inhibiting the effects of androgens (male hormones like testosterone), which stimulate the growth of prostate cancer cells, thereby preventing testosterone from binding to androgen receptors and helping to shrink the prostate tumor. It can also help relieve associated symptoms like difficulty in urination.

Dosage and Administration

The recommended dosage for CALUTIDE 50 MG TABLET is 50 mg once daily, or as advised by a physician. It can be taken orally with or without food, but it is advised to take it at the same time each day, either in the morning or evening, for consistent effect. The tablet should be swallowed whole with a glass of water and should not be crushed, chewed, or broken. It is important to continue taking the medicine regularly as prescribed by your doctor, even if symptoms improve, and not to discontinue use without medical consultation.

Side Effects

• Common Side Effects: Weakness, skin rash, swelling and tenderness of the breast (gynecomastia), nausea, dry skin, weight gain, hair loss, hot flushes, anemia, reduced sex drive (decreased libido), constipation, depression, indigestion, dizziness, fatigue, impotence, breast pain, increased urge to urinate during the night (nocturia), edema (swelling), abdominal pain, flu-like symptoms, infection, pelvic pain, and breathlessness (dyspnea).
• Serious Side Effects (Seek immediate medical attention if experienced): Severe allergic reactions (such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat), yellowing of the skin or eyes (jaundice), loss of appetite, dark urine, severe abdominal pain, unusual bleeding or bruising, irregular heartbeat, significant changes in liver enzymes, or blood in the urine.

Precautions

• Contraindications: CALUTIDE 50 MG TABLET is contraindicated in patients with known hypersensitivity or allergy to bicalutamide or any other components of the tablet. It is not recommended for use in women, including those who are pregnant or breastfeeding, nor is it recommended for children and adolescents under 18 years of age.
• Warnings:
  • Liver Function: Use with caution in patients with a history of liver problems. Regular liver function tests are recommended during treatment, and the dose may need adjustment. Report any signs of liver dysfunction, such as yellowing of skin/eyes, dark urine, or severe abdominal pain, to your doctor immediately.
  • Cardiac Conditions: Exercise caution in patients with heart or blood vessel conditions, including heart rhythm problems.
  • Diabetes: This medicine may affect sugar metabolism. Patients with diabetes should monitor their blood glucose levels regularly.
  • Photosensitivity: CALUTIDE 50 MG TABLET may increase the risk of sunburn. Avoid direct exposure to excessive sunlight or UV light and wear protective clothing when outdoors.
  • Drowsiness/Dizziness: The medication may cause drowsiness or dizziness. Patients should avoid driving or operating heavy machinery if they experience these effects.
  • Alcohol Consumption: It is recommended to limit alcohol consumption while taking this medicine.
  • Drug Interactions: Inform your doctor about all prescription and non-prescription medicines, supplements, and herbal products you are currently taking to avoid potential drug interactions. Avoid concomitant use with cisapride, astemizole, or terfenadine. Use benzodiazepines like midazolam with caution.
  • Do not exceed the prescribed dose.

Storage

Store CALUTIDE 50 MG TABLET at room temperature, typically between 15-30°C (68-77°F), away from moisture and direct sunlight. Keep the tablet container tightly closed and out of the reach and sight of children. Always check the expiry date before use.

CALUTIDE 50 MG TABLET, containing the active ingredient Bicalutamide, is an anti-androgen medication primarily used in the treatment of prostate cancer.

What is Calutide 50 MG Tablet used for?

Calutide 50 MG Tablet is primarily used to treat prostate cancer in adult men. It can be used alone for locally advanced prostate cancer or in combination with other hormonal therapies, such as a gonadotropin-releasing hormone (GnRH) analog or surgical castration, for advanced or metastatic prostate cancer.

How does Calutide 50 MG Tablet work?

Calutide 50 MG Tablet works by blocking the action of androgens (male hormones like testosterone) in the body. Prostate cancer cells often depend on these hormones to grow and spread. By binding to and blocking the androgen receptors on these cancer cells without activating them, Bicalutamide prevents androgens from exerting their effects, thereby slowing the growth and progression of the tumor and potentially shrinking it.

What is the usual dosage of Calutide 50 MG Tablet?

The recommended dosage for Calutide 50 MG Tablet is typically 50 mg per day, taken orally, with or without food, as advised by your doctor. It is important to swallow the tablet whole and not to crush, chew, or break it. The specific dose and duration of treatment will depend on the condition being treated and the doctor's assessment.

What are the possible side effects of Calutide 50 MG Tablet?

Common side effects include hot flashes, breast pain/tenderness or enlargement (gynecomastia), fatigue, nausea, dry skin, weakness, weight gain, hair loss, reduced sex drive (libido), and constipation. More serious side effects can include liver problems (such as yellowing of the skin or eyes, dark urine, upper right stomach pain, unusual bleeding or bruising, or loss of appetite), and rarely, lung disease or severe allergic reactions. Regular monitoring of liver function tests is recommended during treatment.

Is Calutide 50 MG Tablet safe during pregnancy or breastfeeding?

Calutide 50 MG Tablet is not recommended for use in women, including those who are pregnant or breastfeeding, as it is contraindicated and may harm the unborn baby or affect hormone levels. Effective birth control measures are recommended for male patients and their partners during treatment and for a period after discontinuing the medication.

Can Calutide 50 MG Tablet be taken with other medications?

Calutide 50 MG Tablet can interact with certain medications. For instance, it may alter the effectiveness of blood-thinning medications like warfarin, increasing the risk of bleeding. It may also interact with some antipsychotic medicines and benzodiazepines like midazolam. It's crucial to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

What precautions should be taken when using Calutide 50 MG Tablet?

Patients with liver disease, heart problems, or diabetes should inform their doctor before taking Calutide 50 MG Tablet, as caution may be needed and regular monitoring might be required. This medication can make your skin more sensitive to sunlight, so it's advisable to avoid direct exposure to excessive UV light and wear protective clothing when outdoors. If you experience dizziness or drowsiness, avoid driving or operating machinery.

What happens if a dose of Calutide 50 MG Tablet is missed?

If you miss a dose of Calutide 50 MG Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should Calutide 50 MG Tablet be stored?

Calutide 50 MG Tablet should be stored at room temperature, typically between 15-30°C (68-77°F), away from moisture and direct sunlight. Keep the medicine in a dry place and ensure the container is tightly closed. Always keep it out of the reach of children.