Nimodip 30 Mg Tablet (10 Tab)

NIMODIP 30 MG TABLET

NIMODIP 30 MG TABLET is a medication manufactured by USV PRIVATE LIMITED.

• Name:

  • Brand Name: NIMODIP 30 MG TABLET
  • Common Name: Nimodipine

• Composition:

  • Each film-coated tablet contains 30 mg of Nimodipine. Nimodipine is a dihydropyridine calcium channel blocker.

• Uses: NIMODIP Tablet is primarily used to prevent and treat ischemic neurological deficits and further brain damage following a subarachnoid hemorrhage (SAH). SAH is a type of bleeding around the brain, often due to a ruptured aneurysm. It works by relaxing and widening the blood vessels in the brain, improving blood flow, and preventing vasospasm (narrowing of blood vessels) which can lead to brain damage.

• Dosage and Administration:

  • The typical adult oral dose is 60 mg (two 30 mg tablets) every 4 hours for 21 consecutive days.
  • Treatment should ideally begin within 96 hours of the onset of subarachnoid hemorrhage.
  • Tablets should generally be swallowed whole with a little liquid, preferably at least one hour before or two hours after meals. However, some sources also state it can be taken with or without food.
  • For patients with liver impairment (cirrhosis), the dosage should be reduced to 30 mg every 4 hours, with close monitoring of blood pressure and heart rate.
  • The capsule contents can be removed and administered orally or via a nasogastric tube if swallowing is difficult, but parenteral (intravenous) administration of the capsule contents is contraindicated and has led to serious adverse events.

• Side Effects:

  • Common Side Effects: Headache, nausea, stomach upset, decreased blood pressure (hypotension), light-headedness, irregular heartbeat (tachycardia or bradycardia), muscle pain, rash, flushing, and edema (swelling in extremities).
  • Most common side effects are usually not bothersome and resolve over time.
  • Serious Side Effects: Seek immediate medical attention if you experience signs of an allergic reaction (hives, difficulty breathing, swelling of face, lips, tongue, or throat), or significant changes in heart rate or blood pressure.

• Precautions:

  • Contraindications: Do not administer in cases of hypersensitivity to nimodipine. Concomitant use with rifampicin, phenobarbital, phenytoin, or carbamazepine is contraindicated as it can significantly reduce nimodipine's efficacy. Strong CYP3A4 inhibitors should generally not be administered concurrently.
  • Drug Interactions: Nimodipine may increase the effect of other blood pressure-lowering drugs.
  • Grapefruit Juice: Avoid grapefruit and grapefruit juice as it can increase nimodipine levels and enhance its blood pressure-lowering effect.
  • Medical Conditions: Use with caution in patients with cerebral edema, severely raised intracranial pressure, hypotension, recent myocardial infarction or unstable angina (within one month), congestive heart failure, and liver or kidney impairment.
  • Pregnancy and Breastfeeding: Advised only if the potential benefit outweighs the risk during pregnancy; generally advised to avoid during breastfeeding. Consult your doctor.
  • Alcohol: Avoid alcohol consumption as it may increase dizziness and decreased alertness.
  • Driving: May cause dizziness and decreased alertness; operate machinery or drive only if alert.
  • Pediatric Use: Not recommended for children below 18 years as safety and effectiveness have not been established.

• Storage:

  • Store in a cool and dry place, below 30°C.
  • Keep in the original package to protect from moisture and light.
  • Keep all medicines out of reach of children.

NIMODIP 30 MG TABLET (10 TAB) by USV PRIVATE LIMITED is a medication containing Nimodipine, a calcium channel blocker. It is primarily used to prevent and treat certain types of brain damage following a subarachnoid hemorrhage (bleeding around the brain).

What is NIMODIP 30 MG TABLET used for?

NIMODIP 30 MG TABLET is used to improve neurological outcomes by reducing the incidence and severity of ischemic deficits (brain damage due to insufficient blood flow) in patients who have experienced a subarachnoid hemorrhage (SAH) from a ruptured intracranial aneurysm. It helps prevent changes in brain function after such bleeding.

How does NIMODIP 30 MG TABLET work?

Nimodip Tablet works as a dihydropyridine calcium channel blocker. It relaxes and widens the blood vessels, particularly in the brain, by inhibiting the influx of calcium ions into vascular smooth muscle cells. This action improves blood flow to the brain, prevents vasospasm (narrowing of blood vessels after the hemorrhage), and helps reduce the risk of brain damage caused by insufficient blood supply.

What is the usual dosage of NIMODIP 30 MG TABLET?

For adults, the usual oral dosage is 60 mg (two 30 mg tablets) every 4 hours for 21 consecutive days. Treatment should ideally begin within 96 hours (4 days) of the onset of the subarachnoid hemorrhage. If a patient has cirrhosis (severe liver disease), the dosage may need to be reduced to 30 mg every 4 hours, with close monitoring of blood pressure and heart rate. It is generally recommended to take the tablets at least 1 hour before or 2 hours after meals.

What are the possible side effects of NIMODIP 30 MG TABLET?

Common side effects of Nimodip Tablet include headache, nausea, low blood pressure (hypotension), increased or decreased heart rate, stomach discomfort, rash, muscle cramps, and edema (swelling). More serious, though rare, side effects can include severe dizziness or fainting, very slow or fast heartbeat, unusual bruising or bleeding, and swelling of the arms or legs. If any side effects are bothersome, persist, or worsen, it is important to consult a doctor.

Is NIMODIP 30 MG TABLET safe during pregnancy or breastfeeding?

Nimodip Tablet is generally not recommended for use during pregnancy unless absolutely necessary and the potential benefits clearly outweigh the risks, as there are no adequate and well-controlled studies in pregnant women. For breastfeeding mothers, it is advised to avoid breastfeeding while taking this medication because Nimodipine and its metabolites can be present in human milk.

Can NIMODIP 30 MG TABLET be taken with other medications?

Nimodip Tablet can interact with various medications. It is contraindicated with rifampicin and certain antiepileptic drugs like phenobarbital, phenytoin, or carbamazepine, as these can significantly reduce its effectiveness. Strong inhibitors or inducers of CYP3A4 (a liver enzyme) should generally be avoided or used with caution, requiring close monitoring of blood pressure and heart rate. Concomitant use with other blood pressure-lowering medications may lead to a more pronounced drop in blood pressure. Grapefruit and grapefruit juice should be strictly avoided as they can increase Nimodipine levels in the blood, potentially increasing side effects. Always inform your doctor about all medicines, supplements, and herbal products you are taking.

What precautions should be taken while taking NIMODIP 30 MG TABLET?

It is crucial to monitor blood pressure and heart rate closely during treatment. Caution is advised in patients with cerebral edema (brain swelling) or severely raised intracranial pressure. Patients with liver impairment, particularly cirrhosis, may require a reduced dose and careful monitoring due to slower elimination of the medicine from the body. Alcohol consumption should be avoided as it can increase dizziness. Do not drive or operate machinery until you know how the medicine affects you, as it may cause dizziness or decreased alertness. The contents of the capsule should never be injected intravenously, as this can lead to severe and life-threatening adverse events.

What happens if a dose of NIMODIP 30 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should NIMODIP 30 MG TABLET be stored?

NIMODIP 30 MG TABLET should be stored at room temperature, ideally between 20°C to 25°C (68°F to 77°F), and protected from moisture, heat, and light. Keep the medicine in its original package and out of the reach of children.