Listril 5 Mg Tablet (15 Tab)

LISTRIL 5 MG TABLET

LISTRIL 5 MG TABLET, manufactured by Torrent Pharmaceuticals Ltd., is an Angiotensin-Converting Enzyme (ACE) inhibitor widely used in cardiovascular medicine.

• Name:

  • Brand Name: Listril 5 Tablet
  • Common Name: Lisinopril

• Composition: Each tablet contains 5 mg of Lisinopril as the active ingredient.

• Uses: LISTRIL 5 MG TABLET is primarily prescribed for:

  • High Blood Pressure (Hypertension): It helps lower blood pressure by relaxing and widening blood vessels, making it easier for the heart to pump blood.
  • Heart Failure: It improves heart function and reduces symptoms such as shortness of breath and fatigue.
  • After a Heart Attack: It is used to reduce the risk of severe complications and improve survival rates after a heart attack.
  • Diabetic Kidney Disease: It can also be used to treat kidney problems in diabetic patients with high blood pressure, helping to slow down the disease.

• Dosage and Administration:

  • Typically taken orally once daily, with or without food.
  • Tablets should be swallowed whole with water; do not chew, crush, or break them.
  • For optimal results, it is recommended to take the medicine at the same time each day.
  • The initial dose for hypertension is often 10 mg daily, which may be adjusted by a doctor. For heart failure, a starting dose of 2.5 mg or 5 mg daily is common. Following a heart attack, the initial dose is typically 5 mg within 24 hours, followed by another 5 mg 24 hours later, then 10 mg once daily for at least 6 weeks. Doses may be lower for patients with kidney problems or those on diuretics.

• Side Effects:

  • Common: Headache, dizziness, dry persistent cough, fatigue, nausea, vomiting, diarrhea, and low blood pressure. Dizziness is more common when starting treatment or increasing the dose.
  • Serious (Rare): Angioedema (swelling of the face, lips, tongue, or throat), severely low blood pressure, severe kidney problems, liver problems (yellowing of skin/eyes, dark urine), and high potassium levels in the blood (hyperkalemia).

• Precautions:

  • Pregnancy and Breastfeeding: Not recommended during pregnancy due to potential harm to the fetus, especially in the second and third trimesters. Consult a doctor if pregnant or breastfeeding.
  • Allergies: Avoid if allergic to lisinopril or other ACE inhibitors.
  • Medical Conditions: Use with caution in patients with kidney disease, liver disease, diabetes, or a history of angioedema.
  • Interactions: Inform your doctor about all medications, supplements, or herbal products being taken. Avoid concomitant use with aliskiren (especially in diabetics or those with kidney problems) and sacubitril/valsartan due to increased risk of side effects. Potassium supplements or high-potassium foods should be avoided due to the risk of hyperkalemia. Alcohol consumption should be avoided as it can increase dizziness and lower blood pressure.
  • Monitoring: Regular monitoring of blood pressure, electrolyte levels, and kidney function is advised.
  • Driving: May cause dizziness or lightheadedness; avoid driving or operating heavy machinery until you know how the medicine affects you.

• Storage: Store at room temperature, away from heat, direct light, and moisture. Keep out of reach of children and pets.

Here are frequently asked questions about LISTRIL 5 MG TABLET, a medication containing Lisinopril:

What is LISTRIL 5 MG TABLET used for?

LISTRIL 5 MG TABLET is primarily used to treat high blood pressure (hypertension) in adults and children aged 6 years and older. It is also prescribed to manage heart failure and to improve survival after a heart attack. Additionally, it may be used to help prevent kidney problems in individuals with diabetes.

How does LISTRIL 5 MG TABLET work?

LISTRIL 5 MG TABLET contains Lisinopril, which belongs to a class of medicines called Angiotensin-Converting Enzyme (ACE) inhibitors. It works by blocking the conversion of a substance called angiotensin I into angiotensin II, a potent chemical that narrows blood vessels. By inhibiting angiotensin II, Lisinopril causes blood vessels to relax and widen, making it easier for blood to flow and reducing the workload on the heart. This action helps to lower high blood pressure.

What is the usual dosage for LISTRIL 5 MG TABLET?

The dosage of LISTRIL 5 MG TABLET varies depending on the condition being treated and individual patient factors. It is usually taken once a day, around the same time each day, and can be taken with or without food.

• For high blood pressure: The initial adult dose is typically 10 milligrams (mg) once daily, which your doctor may adjust up to a maximum of 40 mg per day. If taken with diuretics, the starting dose might be 5 mg once daily.
• For heart failure: The usual starting dose for adults is 5 mg once daily, and can be increased as needed, typically not exceeding 40 mg per day. In some cases, such as with low blood sodium levels, a starting dose of 2.5 mg once daily may be prescribed.
• After a heart attack: Treatment often starts with 5 mg within 24 hours, followed by another 5 mg after 24 hours, then 10 mg after 48 hours, and then 10 mg once daily for at least six weeks. A lower dose of 2.5 mg once daily might be used if your blood pressure is low.

What are the possible side effects of LISTRIL 5 MG TABLET?

Common side effects include headache, dizziness, fatigue, and a dry cough. You may also experience nausea or a skin rash.

More serious side effects, though rare, can occur and require immediate medical attention. These include angioedema (severe swelling of the face, lips, tongue, or throat, which can cause difficulty breathing or swallowing), very low blood pressure (hypotension), high blood potassium levels (hyperkalemia), liver problems (yellowing of skin or eyes), and kidney damage. Fever, chills, or a sore throat could be symptoms of an infection related to low white blood cells. Severe stomach pain, with or without nausea or vomiting, should also be reported to your doctor immediately.

Is LISTRIL 5 MG TABLET safe during pregnancy or breastfeeding?

Pregnancy: LISTRIL 5 MG TABLET is generally not recommended during pregnancy and is contraindicated during the second and third trimesters. Taking it during these periods can cause serious harm to the unborn baby, including kidney damage, poor lung and skull bone development, low amniotic fluid, and even fetal death. If you become pregnant while taking this medication, stop taking it and consult your doctor immediately.

Breastfeeding: The safety of Lisinopril during breastfeeding is not fully established. While some studies suggest minimal transfer into breast milk, there's a potential risk of low blood pressure in the infant, especially for premature or very young babies (under one month old). A healthcare provider should assess the benefits of the medication for the mother against any potential risks to the infant to determine if it's appropriate to continue or discontinue the drug or nursing.

Can LISTRIL 5 MG TABLET be taken with other medications?

LISTRIL 5 MG TABLET can interact with several other medications, potentially altering their effects or increasing the risk of side effects.

• Avoid taking with:
  • Aliskiren: Especially if you have diabetes or kidney problems, as this combination can significantly increase the risk of very low blood pressure, high potassium levels, and kidney damage.
  • Sacubitril/Valsartan (e.g., Entresto): This combination increases the risk of a serious allergic reaction called angioedema. You should not take LISTRIL 5 MG TABLET within 36 hours before or after taking sacubitril/valsartan.
• Inform your doctor about, or use with caution with:
  • Diuretics (water pills): Taking these together can lead to a severe drop in blood pressure and may increase potassium levels.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs), such as ibuprofen or naproxen: These can reduce the blood pressure-lowering effect of Lisinopril and increase the risk of kidney damage, particularly in older patients or those who are dehydrated.
  • Potassium supplements, potassium-sparing diuretics (e.g., spironolactone, amiloride), or salt substitutes containing potassium: These can increase the risk of dangerously high blood potassium levels (hyperkalemia).
  • Lithium: Lisinopril can increase the levels of lithium in your body, potentially leading to toxicity.
  • Antidiabetic medications (e.g., insulin, oral hypoglycemic agents): Co-administration can increase the risk of low blood sugar (hypoglycemia).
  • Sirolimus and Everolimus: May increase the risk of angioedema.

Always tell your doctor and pharmacist about all prescription and non-prescription medications, vitamins, nutritional supplements, and herbal products you are taking.

What precautions should be taken when taking LISTRIL 5 MG TABLET?

It is very important to have your progress checked regularly by your doctor. This includes monitoring your blood pressure and undergoing blood tests to check kidney function and potassium levels.

Avoid dehydration by drinking plenty of water, especially during exercise or in hot weather, as dehydration can lead to abnormally low blood pressure. Rise slowly when getting up from a lying or sitting position to prevent dizziness or fainting.

Inform your healthcare provider if you have a history of angioedema (swelling of the face, throat, or other body parts) or an allergy to ACE inhibitors. Individuals of African ancestry may have an increased risk of angioedema and might not respond as effectively to ACE inhibitors.

Caution is advised with alcohol consumption, as it can further lower blood pressure and increase dizziness. Also, inform any doctor or dentist treating you about your use of Lisinopril, especially if you have planned surgery.

What happens if a dose of LISTRIL 5 MG TABLET is missed?

If you miss a dose of LISTRIL 5 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one.

How should LISTRIL 5 MG TABLET be stored?

LISTRIL 5 MG TABLET should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F). Keep the tablets in their tightly sealed container, protected from moisture, excessive heat, and direct light. Do not freeze the medication. Always keep LISTRIL 5 MG TABLET out of the reach of children and pets. Dispose of any unused medication after its expiration date.