Sacuhart 100 Tab

SACUHART 100 Tablet is a medication developed by MACLEODS PHARMACEUTICALS LTD, primarily used for the management of chronic heart failure. It belongs to a class of drugs known as Angiotensin Receptor Neprilysin Inhibitors (ARNIs).

• Name: SACUHART 100 Tablet
• Composition: Each tablet contains Sacubitril 49 mg and Valsartan 51 mg.
• Uses:
  • Manages chronic heart failure in adults, particularly those with reduced ejection fraction (NYHA Class II-IV).
  • Reduces the risk of cardiovascular death and hospitalization due to heart failure.
  • Alleviates symptoms such as shortness of breath, fatigue, and swelling in the feet and ankles.
  • Improves the heart's ability to pump blood efficiently and enhances the quality of life for patients with heart failure.
• Dosage and Administration:
  • Take orally, usually twice daily, with or without food.
  • Swallow the tablet whole; do not crush or chew.
  • Follow your doctor's prescribed dosage and duration of treatment.
  • Maintain consistency in timing for optimal benefits.
• Side Effects:
  • Common: Low blood pressure (hypotension), high potassium levels in the blood (hyperkalemia), impaired renal function (kidney problems), dizziness, cough, headache, fatigue, nausea, weakness, and diarrhea.
  • Consult your doctor if any side effects worsen or become persistent.
• Precautions:
  • Not recommended during pregnancy or breastfeeding due to potential harm to the baby.
  • Contraindicated with ACE inhibitors or within 36 hours of discontinuing an ACE inhibitor due to the risk of angioedema.
  • Use with caution in patients with liver or kidney impairment, and in older patients.
  • Avoid potassium supplements and potassium-rich foods to prevent hyperkalemia.
  • Limit alcohol consumption as it may increase dizziness or fatigue.
  • May cause dizziness; avoid driving or operating heavy machinery if affected.
  • Not for use in children under 18 years of age.
• Storage:
  • Store in a closed container at room temperature, ideally below 30°C.
  • Keep away from direct sunlight and moisture.
  • Ensure it is out of reach of children.

SACUHART 100 TAB is a fixed-dose combination medication containing Sacubitril (49 mg) and Valsartan (51 mg), primarily used in the management of chronic heart failure. It belongs to a class of drugs known as Angiotensin Receptor Neprilysin Inhibitors (ARNIs). This medicine helps reduce the risk of cardiovascular death and hospitalization in adults with chronic heart failure who have reduced ejection fraction.

Here are some frequently asked questions about SACUHART 100 TAB:

What is SACUHART 100 TAB used for?

SACUHART 100 TAB is used to treat chronic heart failure in adults, particularly those with reduced ejection fraction (New York Heart Association Class II-IV heart failure). It helps to reduce the risk of cardiovascular death and hospitalizations due to worsening heart failure, and can also alleviate symptoms such as shortness of breath, fatigue, and swelling in the feet and ankles.

How does SACUHART 100 TAB work?

SACUHART 100 TAB combines two active ingredients: Sacubitril and Valsartan. Sacubitril inhibits the enzyme neprilysin, which typically breaks down natriuretic peptides. By blocking neprilysin, sacubitril increases the levels of these beneficial peptides that help relax blood vessels, increase sodium and water excretion, and reduce strain on the heart. Valsartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of angiotensin II, a hormone that causes blood vessels to narrow. Together, these actions relax and widen blood vessels, making it easier for the heart to pump blood, reduce blood pressure, and decrease fluid retention.

What is the usual dosage of SACUHART 100 TAB?

The dosage of SACUHART 100 TAB is determined by your doctor based on your medical condition and response to the medicine. For adults, a common starting dose is 49 mg sacubitril/51 mg valsartan orally twice daily. This dose may be gradually increased over 2-4 weeks to a target maintenance dose of 97 mg sacubitril/103 mg valsartan orally twice daily, as tolerated. It's crucial not to exceed the prescribed dose without consulting your doctor.

What are the possible side effects of SACUHART 100 TAB?

Common side effects include dizziness, light-headedness (due to low blood pressure), high potassium levels in the blood (hyperkalaemia), kidney problems, and cough. More serious but rare side effects can include angioedema (swelling of the face, lips, tongue, or throat), which requires immediate medical attention. If you experience any severe or worsening symptoms, consult your doctor immediately.

Is SACUHART 100 TAB safe during pregnancy or breastfeeding?

No, SACUHART 100 TAB is not recommended during pregnancy as it can cause serious harm or even death to the unborn baby. Women of childbearing age should use effective contraception while taking this medication. It is also not recommended for use during breastfeeding due to potential risks to the baby. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can SACUHART 100 TAB be taken with other medications?

SACUHART 100 TAB can interact with several medications. It should not be taken with ACE inhibitors (like enalapril or lisinopril) due to an increased risk of angioedema; a 36-hour washout period is required when switching between these medications. Concomitant use with potassium-sparing diuretics or potassium supplements can increase the risk of high potassium levels (hyperkalaemia). NSAIDs (like ibuprofen) may decrease its blood pressure-lowering effect and increase the risk of kidney problems. It is also contraindicated with aliskiren in patients with diabetes or impaired kidney function. Inform your doctor about all medications, supplements, and herbal remedies you are taking.

What precautions should be taken with SACUHART 100 TAB?

Precautions include monitoring for symptoms of low blood pressure, especially when standing up quickly. Patients with kidney disease or liver disease may require dose adjustments and special monitoring. It should be used with caution in elderly patients, and regular monitoring is necessary. If you have a history of angioedema, particularly related to ACE inhibitors or ARBs, you should not take this medication. Alcohol consumption should be limited as it may intensify side effects like dizziness.

What happens if a dose is missed?

If you miss a dose of SACUHART 100 TAB, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

How should SACUHART 100 TAB be stored?

SACUHART 100 TAB should be stored in a closed container at room temperature, ideally below 30°C (86°F), and protected from moisture and light. Keep the medicine out of reach of children and pets. Always check the expiry date on the packaging.