Lizolid I.v 300ml

LIZOLID I.V. 300ML by INTEGRACE ORTHO

LIZOLID I.V. 300ML is an antibiotic medication used to treat severe bacterial infections. It is administered intravenously and is effective against a range of susceptible Gram-positive bacteria, including those resistant to other antibiotics.

• Name: Lizolid I.V. (Brand Name). The common name for the active ingredient is Linezolid. It is supplied by Integrace Ortho (or Integrace Private Limited).

• Composition: Each 300ML vial contains 600 mg of Linezolid (2 mg/ml concentration).

• Uses: Lizolid I.V. is prescribed for the treatment of severe bacterial infections, including:

  • Lung infections (pneumonia), both community-acquired and nosocomial.
  • Skin and soft tissue infections, including complicated and uncomplicated cases, and diabetic foot infections.
  • Infections caused by resistant organisms such as Methicillin-Resistant Staphylococcus aureus (MRSA) and Vancomycin-Resistant Enterococci (VRE). It works by inhibiting bacterial protein synthesis, thereby stopping the growth of infection-causing bacteria. It is not effective against viral infections.

• Dosage and Administration: This medication is administered as an intravenous (IV) infusion (drip) over a period of 30 minutes to 2 hours.

  • Adults and Children 12 years and older: Typically 600 mg intravenously every 12 hours.
  • Children under 12 years: Usually 10 mg/kg intravenously every 8 hours. The duration of treatment generally ranges from 10 to 14 consecutive days, but may extend up to 28 days depending on the infection. It is crucial to take the medicine regularly at evenly spaced intervals and complete the full course as prescribed, even if symptoms improve, to prevent the infection from returning. The solution should not be mixed with other medications.

• Side Effects:

  • Common: Headache, metallic taste, diarrhea (which can be severe and prolonged), nausea, vomiting, dizziness, constipation, indigestion, localized pain, rash, altered taste perception, discoloration of the tongue, and decreased blood cell counts (red, white, and platelets).
  • Serious: Serotonin syndrome (especially when taken with certain other medications), bone marrow suppression (thrombocytopenia, anemia, leukopenia), lactic acidosis, peripheral and optic neuropathy (particularly with prolonged use beyond 28 days), blurred vision, seizures, and hypertension.

• Precautions:

  • Inform your doctor about any known allergies to Linezolid or its components.
  • Avoid use if taking or if you have taken monoamine oxidase (MAO) inhibitors (e.g., phenelzine, selegiline) within the last 14 days, due to the risk of serious interactions.
  • Use with caution in patients with a history of high blood pressure, overactive thyroid, pheochromocytoma, carcinoid syndrome, manic depression, schizophrenia, diabetes, severe kidney or liver disease, bone marrow depression, or seizures.
  • Limit consumption of tyramine-rich foods (e.g., aged cheese, red wine, fermented products) to prevent a significant increase in blood pressure.
  • Avoid alcohol during treatment as it may increase dizziness.
  • This medication may cause dizziness or vision problems; exercise caution when driving or operating machinery.
  • Breastfeeding mothers should discontinue nursing during treatment, as Linezolid passes into breastmilk and can affect the infant.

• Storage: Store in a cool and dry place, protected from sunlight, at temperatures between 10ºC and 25ºC or below 30ºC. Keep the infusion bags in their foil outer wrap until ready for use and protect from freezing. Keep out of reach and sight of children.

LIZOLID I.V. 300ML contains Linezolid, an antibiotic used to treat serious bacterial infections. It is administered intravenously under the supervision of a healthcare professional.

What is LIZOLID I.V. 300ML used for?

LIZOLID I.V. 300ML is used to treat severe bacterial infections, particularly those caused by Gram-positive bacteria, including resistant strains like MRSA (Methicillin-Resistant Staphylococcus aureus) and VRE (Vancomycin-Resistant Enterococci). It is commonly prescribed for infections of the lungs (pneumonia), skin, and soft tissues, including complicated skin and skin structure infections. It is not effective against infections caused by viruses like the common cold or flu.

How does LIZOLID I.V. 300ML work?

LIZOLID I.V. 300ML (Linezolid) is an antibiotic belonging to the oxazolidinone class. It works by stopping the growth of infection-causing bacteria. It achieves this by preventing the synthesis of essential proteins that bacteria require to carry out vital functions, thus inhibiting their ability to reproduce.

What is the usual dosage of LIZOLID I.V. 300ML?

For adults, the typical recommended dosage for LIZOLID I.V. 300ML (Linezolid) is 600 mg (which is 300 mL of the solution) administered intravenously every 12 hours. The infusion should be given slowly over a period of 30 to 120 minutes. The duration of treatment usually ranges from 10 to 14 days, but it can extend up to 28 days depending on the type and severity of the infection. For pediatric patients, the dosage is typically weight-based and administered every 8 hours.

What are the possible side effects of LIZOLID I.V. 300ML?

Common side effects include headache, nausea, vomiting, diarrhea, and decreased blood cell counts (red blood cells, white blood cells, and platelets). Other reported side effects include abdominal pain, rash, altered taste perception, and dizziness. More serious side effects, though less common, can include serotonin syndrome, lactic acidosis, bone marrow suppression, and vision changes (such as blurred vision or optic neuropathy), particularly with prolonged use. If severe diarrhea occurs, especially with blood or mucus, or if you experience any serious or concerning side effects, contact your doctor immediately.

Is LIZOLID I.V. 300ML safe during pregnancy or breastfeeding?

LIZOLID I.V. 300ML may be unsafe to use during pregnancy and breastfeeding. While animal studies have shown potential risks during pregnancy, human studies are limited. For breastfeeding mothers, Linezolid passes into breast milk, and it is generally recommended to avoid its use or consider alternative treatments, especially when nursing newborns or preterm infants, due to potential risks to the baby. Always consult your doctor to weigh the potential benefits against the risks.

Can LIZOLID I.V. 300ML be taken with other medications?

LIZOLID I.V. 300ML (Linezolid) can interact with several medications. It is a weak monoamine oxidase inhibitor (MAOI), meaning it can increase levels of certain natural substances in the body like serotonin, dopamine, and norepinephrine. Therefore, it should not be used with other MAO inhibitors or within two weeks of stopping them. Co-administration with serotonergic drugs (e.g., SSRIs, opioids like pethidine, tramadol) can lead to serotonin syndrome, a serious condition. It can also interact with adrenergic drugs (e.g., pseudoephedrine, epinephrine) potentially causing a hypertensive crisis. Inform your doctor about all other medicines you are taking, including over-the-counter drugs and herbal supplements, to avoid potential interactions.

What precautions should be taken with LIZOLID I.V. 300ML?

Several precautions should be observed while receiving LIZOLID I.V. 300ML. It's important to complete the full course of treatment as prescribed, even if you feel better, to prevent the infection from returning or becoming resistant. Avoid excessive consumption of tyramine-rich foods (e.g., aged cheese, fermented meats, red wine, soy sauce) as this can lead to a significant increase in blood pressure. Your doctor may monitor your blood counts regularly, especially with prolonged use, due to the risk of myelosuppression. Inform your doctor if you have a history of high blood pressure, kidney or liver problems, diabetes, seizures, or blood disorders. This medicine may cause dizziness or visual problems, so caution is advised when driving or operating machinery.

What happens if a dose of LIZOLID I.V. 300ML is missed?

Since LIZOLID I.V. 300ML is administered under the supervision of a healthcare professional, it is unlikely that a dose will be missed. However, if you believe a dose was missed, inform your doctor or nurse immediately. Do not try to double the dose to make up for a forgotten one.

How should LIZOLID I.V. 300ML be stored?

LIZOLID I.V. 300ML should be stored at room temperature, typically below 25°C or 30°C. The infusion bags should be kept in their foil outer wrap until ready for use to protect them from light and freezing. Keep all medications out of the reach of children and pets.