Dapanova S 10/100 Tab

DAPANOVA S 10/100 TAB is a medication manufactured by Medley Pharmaceuticals, designed for the management of type 2 diabetes mellitus.

Name

• Brand Name: DAPANOVA S 10/100 TAB

Composition

• Active Ingredients: Each tablet contains Dapagliflozin 10 mg and Sitagliptin 100 mg.
  • Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor that works by increasing glucose excretion in the urine, thereby lowering blood glucose levels.
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances the body's natural incretins, improving insulin synthesis and decreasing glucagon release to reduce glucose production by the liver.

Uses

DAPANOVA S 10/100 TAB is used to treat type 2 diabetes mellitus in adults, particularly when blood sugar levels are inadequately controlled by diet and exercise alone or metformin monotherapy. It helps control blood sugar levels, improve insulin sensitivity, and reduce glucose production. This medication also helps prevent serious complications of diabetes such as kidney damage, eyesight loss (retinopathy), nerve damage (neuropathy), and diabetic foot ulcer. Additionally, it may reduce the risk of heart attack, heart failure, or other cardiovascular events.

Dosage and Administration

Take DAPANOVA S 10/100 TAB orally as directed by your physician, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not crushed or chewed. It is recommended to take the medicine at the same time each day for optimal benefits. Do not stop taking the medication without consulting your doctor, as this may lead to increased blood sugar levels and potential complications.

Side Effects

Common Side Effects:

• Diarrhoea, nausea, vomiting, stomach pain, flatulence, constipation
• Headache, dizziness
• Frequent urination, urinary tract infection (UTI), painful urination
• Hypoglycaemia (low blood sugar), especially when used with other antidiabetic medicines
• Upper respiratory tract infection, nasal congestion, sore throat, common cold
• Fungal infections in the genital area
• Back pain, joint pain
• Dehydration, light-headedness

Serious Side Effects (Seek immediate medical attention if you experience):

• Inflamed pancreas (severe and persistent stomach pain)
• Serious allergic reactions (rash, hives, blisters, swelling of face, tongue, lips, difficulty breathing or swallowing)
• Severe gastrointestinal problems (in case of overdose)

Precautions

• Pregnancy and Breastfeeding: Not recommended during pregnancy, especially in the second and third trimesters, and caution is advised during breastfeeding. Consult your doctor if pregnant or planning to conceive.
• Alcohol: Avoid excessive alcohol intake as it may affect blood sugar control and increase the risk of certain side effects like hypoglycemia.
• Kidney/Liver Problems: Use with caution in patients with kidney or liver issues. Not recommended for patients with severe kidney problems or those on dialysis.
• Other Conditions: Inform your doctor if you have a history of pancreatitis, gallstones, heart failure, or are prone to dehydration.
• Drug Interactions: Inform your doctor about all other medicines, supplements, or herbal products you are taking, especially diuretics, insulin, or insulin secretagogues (like sulfonylureas), as they can increase the risk of hypoglycemia.
• Driving: May cause dizziness or hypoglycemia, so avoid driving or operating machinery if affected.

Storage

Store DAPANOVA S 10/100 TAB in a cool and dry place, away from direct sunlight. Keep it out of the sight and reach of children. It should be stored at 10ºC to 25ºC or below 30ºC.

DAPANOVA S 10/100 TAB: Frequently Asked Questions

DAPANOVA S 10/100 TAB is a medication used to help manage Type 2 Diabetes Mellitus. It contains two active ingredients: Dapagliflozin (10mg) and Sitagliptin (100mg). This combination works through different mechanisms to help lower blood sugar levels.

What is DAPANOVA S 10/100 TAB used for?

DAPANOVA S 10/100 TAB is prescribed for adults with Type 2 Diabetes Mellitus to improve blood sugar control. It is typically used as an adjunct to diet and exercise, and can be used alone or in combination with other diabetes medications like metformin, sulfonylureas, or insulin. It also helps reduce the risk of heart attack, heart failure, or other cardiovascular events in some patients.

How does DAPANOVA S 10/100 TAB work?

This medicine combines two different types of anti-diabetic medications:

• Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works in the kidneys by blocking the reabsorption of glucose, causing excess sugar to be excreted in the urine, thereby lowering blood sugar levels.
• Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by increasing the activity of natural substances in the body called incretin hormones. These hormones stimulate the pancreas to produce more insulin when blood sugar levels are high and decrease the production of glucagon (a hormone that increases blood sugar) by the liver.

What is the usual dosage for DAPANOVA S 10/100 TAB?

The usual dosage is one tablet taken once daily, typically in the morning. It can be taken with or without food, but it is recommended to take it at the same time each day for optimal effectiveness. Your doctor will determine the appropriate dose and duration of treatment.

What are the possible side effects of DAPANOVA S 10/100 TAB?

Common side effects can include urinary tract infections (UTIs), genital yeast infections, headache, dizziness, low blood sugar (hypoglycemia), increased urination, diarrhea, and upper respiratory tract infections. More serious but less common side effects can include diabetic ketoacidosis, severe joint pain, pancreatitis (inflammation of the pancreas), dehydration, and allergic reactions (like rash, swelling of the face/lips/tongue).

Is DAPANOVA S 10/100 TAB safe during pregnancy or breastfeeding?

DAPANOVA S 10/100 TAB is generally not recommended during pregnancy, especially during the second and third trimesters, as there is limited information on its use and potential risks. It is also not advised during breastfeeding because it's unknown how much of the medication passes into breast milk and could potentially affect the infant. Always consult your doctor if you are pregnant, planning to conceive, or breastfeeding.

Can DAPANOVA S 10/100 TAB be taken with other medications?

It's crucial to inform your doctor about all other medications, supplements, or herbal products you are currently taking to avoid potential drug interactions.

• Insulin and Insulin Secretagogues (e.g., sulfonylureas): Combining DAPANOVA S with these medications may increase the risk of hypoglycemia (low blood sugar), and dose adjustments might be necessary.
• Diuretics (water pills): Co-administration with diuretics can increase the risk of dehydration and low blood pressure.
• Other medications: Your doctor will assess for interactions with other drugs, including antifungals (e.g., ketoconazole), antivirals (e.g., ritonavir), antibiotics (e.g., clarithromycin), immunosuppressants (e.g., ciclosporin), and cardiac glycosides (e.g., digoxin).

What precautions should be taken while using DAPANOVA S 10/100 TAB?

Inform your doctor if you have kidney or liver problems, a history of pancreatitis, gallstones, alcohol dependence, heart problems, or a history of urinary tract or genital infections. The medicine should not be used in patients with severe kidney impairment or those on dialysis. Maintain adequate hydration to prevent dehydration. If you experience severe abdominal pain, signs of a serious allergic reaction, or symptoms of diabetic ketoacidosis (nausea, vomiting, stomach pain, increased thirst, fruity breath odor), seek immediate medical attention.

What happens if a dose of DAPANOVA S 10/100 TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should DAPANOVA S 10/100 TAB be stored?

Store the medicine in a cool, dry place below 30°C, away from direct sunlight, heat, and moisture. Keep it out of the reach of children and pets.