Aplevant 0.75mg Pens Box

APLEVANT 0.75MG PENS BOX

Name

• Brand Name: APLEVANT 0.75MG PENS BOX
• Common Name (Active Ingredient): Dulaglutide

Composition

• Active Ingredient: Dulaglutide (0.75 mg)
• Other Ingredients: Citric Acid (0.07 mg), Mannitol (23.2 mg), Polysorbate 80 (0.1 mg), Tri Sodium Citrate Dihydrate (1.37 mg)

Uses

APLEVANT 0.75MG PENS BOX is an anti-diabetic medication primarily used to treat Type 2 Diabetes Mellitus in adults. It functions as a GLP-1 receptor agonist, mimicking the action of a natural hormone to help control blood sugar levels.

Key uses include:

• Lowering blood sugar levels by increasing insulin release from the pancreas during high blood sugar and decreasing sugar production by the liver.
• Improving insulin sensitivity.
• Reducing the risk of heart diseases in patients with type 2 diabetes.
• Slowing down digestion and reducing appetite, which may contribute to weight loss in some individuals.

Dosage and Administration

APLEVANT 0.75MG PENS BOX is administered as a once-weekly subcutaneous injection into the stomach, thigh, or upper arm. The injection site should be rotated with each dose. It can be taken at any time of day, with or without food, but should be consistently taken on the same day each week. Do not mix insulin and APLEVANT in the same syringe. Do not reuse or share dosing pens.

Side Effects

Common side effects include:

• Nausea, vomiting, diarrhea, decreased appetite
• Stomach pain, constipation
• Feeling tired
• Headache, dizziness, lightheadedness
• Low blood sugar (hypoglycemia), especially when used with other diabetes medications.
• Pain, redness, or swelling at the injection site.

Serious side effects, though less common, can include:

• Pancreatitis (inflammation of the pancreas), characterized by severe abdominal pain.
• Allergic reactions (e.g., anaphylaxis).
• Medullary Thyroid Carcinoma (a type of thyroid cancer).
• Increased heart rate.

Precautions

• Not recommended for children and adolescents under 18 years of age.
• Not suitable for individuals with Type 1 Diabetes.
• Inform your doctor if you have a history of heart, kidney, or liver disease, pancreatitis, or stomach problems.
• Avoid use if you or a close family member has a history of medullary thyroid cancer (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Exercise caution in elderly patients, especially regarding renal function.
• Limit alcohol intake to avoid low blood sugar levels.
• Pregnant and breastfeeding women should consult their doctor before use.
• May cause tiredness; avoid driving or operating machinery until you feel better.
• Monitor blood sugar levels regularly, especially when combining with insulin secretagogues or insulin, to prevent hypoglycemia.
• Do not stop taking this medicine without consulting a doctor.
• Do not use if the solution appears cloudy, discolored, or contains particles.

Storage

• Store in a refrigerator at 2°C to 8°C.
• Do not freeze.
• If refrigeration is not possible, the pen can be kept at room temperature (less than 30°C) for up to 2 weeks.
• Keep out of sight and reach of children.
• Keep away from direct heat and light.

APLEVANT 0.75MG PENS BOX by LUPIN LTD. contains Dulaglutide, an injectable medication primarily used for the management of type 2 diabetes mellitus. It works by helping to control blood sugar levels, and it can also lower the risk of major cardiovascular events in certain patients with type 2 diabetes.

What is APLEVANT 0.75MG used for?

APLEVANT 0.75MG is prescribed for adults with type 2 diabetes mellitus to improve blood sugar control. It is often used when diet and exercise alone are insufficient or when metformin or other oral medications are not enough. This medication can also reduce the risk of serious cardiovascular events such as heart attack and stroke in patients with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors. A secondary benefit for some patients might be weight loss, as it can slow digestion and reduce appetite. It is not intended for the treatment of type 1 diabetes or diabetic ketoacidosis.

How does APLEVANT 0.75MG work?

APLEVANT 0.75MG contains Dulaglutide, which is an incretin mimetic, meaning it mimics the action of a natural hormone called glucagon-like peptide-1 (GLP-1). This active ingredient works by stimulating the pancreas to release more insulin when blood sugar levels are high (after meals). Simultaneously, it decreases the amount of sugar the liver produces and slows down gastric emptying, which helps to reduce blood sugar spikes and contributes to a feeling of fullness.

What is the usual dosage of APLEVANT 0.75MG?

The typical starting dose for APLEVANT 0.75MG is 0.75 mg, administered as a subcutaneous injection once weekly. The dose and duration of treatment will be determined by your doctor, depending on your individual medical condition and response to the medication. It can be taken at any time of day, with or without food, but it is recommended to use it on the same day each week to maintain consistency. Your doctor or nurse will provide instructions on how and where to inject the medicine.

What are the possible side effects of APLEVANT 0.75MG?

Common side effects of APLEVANT 0.75MG include gastrointestinal issues such as nausea, vomiting, diarrhea, decreased appetite, and stomach pain. These symptoms may improve over time. More serious side effects, though less common, can include inflammation of the pancreas (pancreatitis) and an increased risk of thyroid C-cell tumors. Hypoglycemia (low blood sugar) is also a possible side effect, especially when APLEVANT is used with other diabetes medications. It's crucial to seek immediate medical attention if you experience symptoms like severe abdominal pain radiating to the back (pancreatitis) or a lump in your throat, hoarseness, or difficulty speaking (potential thyroid problems).

Is APLEVANT 0.75MG safe during pregnancy or breastfeeding?

APLEVANT 0.75MG may not be safe for use during pregnancy, as animal studies have indicated potential harm to the developing baby. Information regarding its use during breastfeeding is limited, but available data suggests the drug might pass into breast milk, potentially harming the baby, making it likely unsafe. Therefore, pregnant or breastfeeding women should consult their doctor before using this medication, and its use is generally not recommended unless strictly necessary and under close medical supervision.

Can APLEVANT 0.75MG be taken with other medications?

It is important to inform your doctor about all medications, including over-the-counter drugs and herbal supplements, to avoid potential drug interactions. Concomitant use with other diabetes medications, such as insulin or sulfonylureas, can increase the risk of low blood sugar. Certain medications for depression (e.g., fluoxetine), pain (e.g., salicylates), and blood pressure (e.g., ramipril, lisinopril) might also influence blood sugar levels when taken with APLEVANT. Conversely, oral contraceptives, thiazides, steroids, and thyroxine can potentially lead to higher blood sugar levels. If you are also using insulin, do not mix APLEVANT and insulin in the same syringe. Alcohol consumption should be limited or avoided, as it can interfere with how the medication works and increase the risk of both low and high blood sugar levels.

What precautions should be taken with APLEVANT 0.75MG?

Before starting APLEVANT, inform your doctor about any history of heart, kidney, or liver disease, as well as any history of pancreatitis or severe stomach problems. This medication is not recommended for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2. It should not be used for type 1 diabetes. Avoid or limit alcohol intake while on this treatment. If you experience tiredness due to the medication, refrain from driving or operating heavy machinery until you feel well enough. Regular monitoring of blood sugar levels is advised.

What happens if a dose is missed?

If you miss a dose of APLEVANT 0.75MG, inject it as soon as you remember. However, if your next scheduled dose is due within 72 hours (3 days), you should skip the missed dose and continue with your regular once-weekly schedule. Do not take a double dose to make up for a missed one, as this can lead to a dangerous drop in blood glucose levels.

How should APLEVANT 0.75MG be stored?

APLEVANT 0.75MG pens should be stored in a refrigerator, ideally between 2°C and 8°C. It is crucial not to freeze the medication. If refrigeration is not possible, the pen can be stored at room temperature (below 30°C) for up to two weeks. Always keep the pen away from direct heat and light, and out of the sight and reach of children. Do not use the medication if the solution appears cloudy, discolored, or contains particles.