Endogest 100 Capsule (10 Cap)

ENDOGEST 100 CAPSULE (10 CAP) by CIPLA LTD

Endogest 100 Capsule is a hormonal medication containing micronised progesterone, a female hormone essential for regulating menstrual periods and supporting pregnancy. Manufactured by Cipla Ltd., this medicine is available as 100 mg capsules. The micronised form of progesterone ensures better absorption when taken orally.

Composition

• Active Ingredient: Natural Micronised Progesterone 100 mg

Uses Endogest 100 Capsule is prescribed for various conditions related to progesterone deficiency and hormonal imbalance:

• Hormone Replacement Therapy (HRT): Used in conjunction with estrogen to relieve menopausal symptoms such as hot flashes, night sweats, and mood swings, and to prevent endometrial hyperplasia (thickening of the uterine lining) in women with an intact uterus.
• Menstrual Disorders: Treats amenorrhoea (absence of menstrual periods) and regulates irregular menstruation.
• Pregnancy Support: Supports early pregnancy, especially in women at risk of miscarriage due to low progesterone levels, and in preventing preterm labor. It also aids in luteal phase support during assisted reproductive technologies like IVF.
• Female Infertility: Addresses problems related to female infertility by preparing the uterine lining for a fertilized egg.
• Transgender Hormone Therapy: Can be used as a component in transgender hormone therapy to stimulate breast development.

Dosage and Administration

• Endogest 100 mg Tablet is typically taken orally, with or without food, around the same time daily for better results.
• Swallow the capsule whole with a glass of water; do not crush or chew it.
• The dose and duration are prescribed by the doctor based on the individual's medical condition. For some treatments, vaginal application may be recommended by the doctor.

Side Effects Common side effects may include:

• Headache
• Dizziness, drowsiness, or fatigue
• Nausea, vomiting, abdominal bloating, and cramps
• Breast pain and tenderness
• Mood changes or depression
• Vaginal discharge or irregular vaginal bleeding/spotting
• Constipation or diarrhea
• Hot flashes, joint pain, hair loss, or fluid retention

Serious side effects, though less common, warrant immediate medical attention:

• Signs of liver disease (e.g., yellow skin/eyes)
• Severely high blood pressure
• Migraine-like headaches
• Sudden loss of eyesight or double vision
• Signs of a blood clot (e.g., painful swelling/redness of legs, sudden chest pain, trouble breathing)
• Breast lumps, fever, chills, convulsions

Precautions

• Avoid use if allergic to progesterone or any other ingredients in the capsule.
• Not recommended for individuals with undiagnosed abnormal vaginal bleeding, breast cancer or suspected hormone-related cancers, severe liver disease, blood clots or blood clotting disorders, or a history of heart attack or stroke.
• Caution is advised in patients with kidney disease, diabetes, high blood pressure, migraine, gallstones, asthma, fits, systemic lupus erythematosus, or a history of depression.
• Inform your doctor if you are pregnant or breastfeeding, as this medicine may harm an unborn baby and is not recommended during breastfeeding.
• Avoid driving or operating machinery if experiencing drowsiness or dizziness.
• May interact with certain medications, including hepatic enzyme inducers (e.g., barbiturates, carbamazepine, phenytoin), azole antifungals (e.g., ketoconazole), and dopamine agonists (e.g., bromocriptine).
• Alcohol consumption should be avoided as it may increase the risk of side effects like dizziness and drowsiness.

Storage

• Store in a cool and dry place, away from direct sunlight and moisture.
• Keep out of reach and sight of children.
• Store at temperatures between 10ºC to 25ºC or below 30ºC.
• Ensure the medicine is used before its expiry date.

Endogest 100 Capsule is a medication containing natural micronised progesterone, a female hormone crucial for regulating the menstrual cycle and maintaining pregnancy. It is used to address various conditions related to progesterone deficiency.

What is Endogest 100 Capsule used for?

Endogest 100 Capsule is primarily used to manage menstrual and pregnancy-related disorders caused by low progesterone levels. This includes:

• Supporting early pregnancy in women at risk of miscarriage or during assisted reproductive procedures.
• Treating menstrual irregularities such as secondary amenorrhea (absence of periods) and abnormal uterine bleeding.
• Alleviating menopausal symptoms like hot flashes, night sweats, and mood swings as part of Hormone Replacement Therapy (HRT), often in combination with estrogen.
• Managing symptoms of premenstrual syndrome (PMS).

How does Endogest 100 Capsule work?

Endogest 100 Capsule contains natural micronised progesterone, which supplements the body's progesterone levels. Progesterone plays a vital role in preparing the uterine lining (endometrium) for the implantation of a fertilised egg and sustaining early pregnancy. It also balances the effects of estrogen on the endometrium, preventing excessive thickening, and helps regulate the menstrual cycle. The micronised form ensures better absorption when taken orally.

What is the usual dosage of Endogest 100 Capsule?

The dosage of Endogest 100 Capsule varies depending on the medical condition being treated and should always be as prescribed by your doctor. It is typically taken once daily, often in the evening or at bedtime, with food for better absorption. In some cases, it may be prescribed in two divided doses or for a specific duration within a menstrual cycle. For vaginal administration, an applicator may be used as directed by your doctor.

What are the possible side effects of Endogest 100 Capsule?

Common side effects of Endogest 100 Capsule can include nausea, vomiting, abdominal bloating and cramps, breast tenderness, headache, and dizziness. Other reported side effects include fatigue, drowsiness, abnormal vaginal bleeding or discharge, mood swings, and constipation. More serious, though less common, side effects can include signs of liver disease (e.g., yellow skin/eyes), severely high blood pressure, new migraine-like headaches, sudden vision changes, or signs of a blood clot (e.g., painful swelling in legs, sudden chest pain). If you experience any severe or persistent side effects, consult your doctor immediately.

Is Endogest 100 Capsule safe during pregnancy or breastfeeding?

Endogest 100 Capsule can be used during pregnancy if prescribed by a doctor, especially to support early pregnancy and reduce the risk of miscarriage due to low progesterone levels. Most studies suggest low or no risk to the developing baby.

For breastfeeding, caution is advised. While human studies suggest that the drug may not pass into breastmilk in significant amounts and may not be harmful to the baby, it is generally not recommended for use during breastfeeding unless specifically advised by your doctor.

Can it be taken with other medications?

Endogest 100 Capsule may interact with several medications, potentially affecting its effectiveness or increasing the risk of side effects. It's crucial to inform your doctor about all medications, supplements, and herbal remedies you are currently taking. Some notable interactions include:

• Hepatic enzyme inducers (e.g., barbiturates, carbamazepine, phenytoin, rifampicin) may decrease progesterone levels.
• Azole antifungals (e.g., ketoconazole) can increase progesterone concentrations.
• Dopamine agonists (e.g., bromocriptine) may have reduced efficacy.
• Antibiotics (e.g., ampicillin, tetracyclines) and St. John's Wort can also interact.
• Fatty foods can enhance progesterone absorption.

What precautions should be taken?

Before taking Endogest 100 Capsule, inform your doctor about any existing medical conditions or history, especially:

• Liver disease: Not recommended for severe liver disease.
• Breast or genital tract cancer: Not recommended if you have or suspect hormone-related cancers.
• Blood clotting disorders/history of stroke or heart attack: May increase the risk of blood clots.
• Hypertension (high blood pressure): Regular monitoring is advised.
• Diabetes: Closely monitor glucose levels as it may affect blood sugar control.
• Epilepsy, migraine, asthma, kidney dysfunction, photosensitivity, or depression.
• Avoid alcohol consumption as it may increase side effects like dizziness and drowsiness.
• This medicine can cause drowsiness or dizziness, so caution is advised while driving or operating machinery.

What happens if a dose is missed?

If you miss a dose of Endogest 100 Capsule, take it as soon as you remember. However, if it is nearly time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one without consulting your doctor. Missing a single dose is unlikely to have a significant impact on pregnancy.

How should it be stored?

Endogest 100 Capsule should be stored in a closed container at room temperature, ideally below 30°C (86°F), and protected from direct sunlight and moisture. Keep the medicine out of reach of children and pets, and ensure it is used before its expiry date.