Briv 25 Mg Tablet (10 Tab)

BRIV 25 MG TABLET

BRIV 25 MG TABLET is an anti-epileptic medication manufactured by Dr. Reddy's Laboratories Ltd., used to manage seizures associated with epilepsy.

Name

• Common Name: Brivaracetam 25 mg Tablet
• Brand Names: BRIV 25 MG TABLET, Briviact (a common brand name for brivaracetam)

Composition Each tablet contains 25 mg of Brivaracetam as its active ingredient. Brivaracetam is a pyrrolidine derivative and works by selectively binding to synaptic vesicle protein 2A (SV2A) in the brain, which helps stabilize abnormal electrical activity and reduce seizure frequency and severity.

Uses BRIV 25 MG TABLET is prescribed for the treatment of partial-onset seizures (also known as focal seizures) in patients with epilepsy. It can be used alone (monotherapy) or in combination with other anti-epileptic medications (adjunctive therapy) in adults and children aged 1 month and older.

Dosage and Administration The tablet should be swallowed whole with a glass of water, and should not be crushed, broken, or chewed. It can be taken with or without food, but it is recommended to take it at the same time each day for optimal effectiveness. Dosage is determined by a doctor based on individual response and severity of epilepsy, and may be adjusted gradually. For adults and children weighing 50 kg or more, an initial dose might be 25 to 50 mg twice daily, with a usual maximum of 100 mg twice daily. It is crucial to follow the prescribed dosage and not to alter it without consulting a doctor.

Side Effects Common side effects may include:

• Drowsiness, dizziness, fatigue (tiredness)
• Nausea, vomiting, headache
• Irritability, coordination problems

More serious side effects can include changes in mood or behavior such as depression, anxiety, anger, restlessness, agitation, aggression, and thoughts of self-harm or suicide. Severe allergic reactions, indicated by swelling of the face, throat, tongue, lips, or difficulty breathing, should be reported immediately.

Precautions

• Abrupt Discontinuation: Do not stop taking BRIV 25 MG TABLET suddenly, as this can worsen seizures or lead to status epilepticus. Gradual reduction under medical supervision is necessary.
• Mental Health: Patients should be monitored for changes in mood, behavior, or suicidal thoughts, especially during the initial months of treatment.
• Driving and Machinery: Avoid driving or operating heavy machinery until you know how the medicine affects you, as it can cause drowsiness, dizziness, and coordination problems.
• Alcohol: Avoid alcohol consumption as it can enhance drowsiness and other central nervous system depressant effects.
• Medical Conditions: Inform your doctor about any history of liver or kidney problems, depression, or drug use disorders, as dose adjustments or caution may be required.
• Pregnancy and Breastfeeding: Caution is advised during pregnancy and breastfeeding. Consult your doctor if you are pregnant, planning to conceive, or breastfeeding.
• Drug Interactions: Inform your doctor about all medicines, including other anti-epileptic drugs, antibiotics (e.g., rifampicin), and central nervous system depressants, as interactions can affect efficacy or increase side effects.

Storage Store BRIV 25 MG TABLET in a cool and dry place, away from direct sunlight and moisture. The typical storage temperature is below 30°C or between 10°C to 25°C. Keep the medicine out of sight and reach of children and pets.

Here are some frequently asked questions about BRIV 25 MG TABLET (Brivaracetam), an anti-epileptic medication:

What is BRIV 25 MG TABLET used for?

BRIV 25 MG TABLET, containing brivaracetam, is an anti-epileptic medication primarily used to treat partial-onset seizures (also known as focal seizures) in individuals with epilepsy. It can be used alone (monotherapy) or in combination with other anti-epileptic drugs in adults and children aged 1 month and older. It helps to reduce the frequency and severity of seizures by stabilizing abnormal electrical activity in the brain.

How does BRIV 25 MG TABLET work?

BRIV 25 MG TABLET works by binding to a specific protein called synaptic vesicle glycoprotein 2A (SV2A) found on the surfaces of nerve cells in the brain. This action helps to regulate neurotransmitter release, suppressing abnormal activity of nerve cells and preventing the spread of electrical signals that cause seizures. It stabilizes neuronal disturbance in the brain.

What is the usual dosage of BRIV 25 MG TABLET?

The dosage of BRIV 25 MG TABLET (brivaracetam) is determined by your doctor and may vary based on age, body weight, and individual response to treatment. For adults and adolescents 16 years and older, the usual starting dose is often 50 mg twice daily, which can be adjusted between 25 mg and 100 mg twice daily. For children, the dose is based on body weight. Tablets should be swallowed whole with liquid and can be taken with or without food, ideally at the same time each day for consistency. Do not crush, break, or chew the tablets.

What are the possible side effects of BRIV 25 MG TABLET?

Common side effects of BRIV 25 MG TABLET may include dizziness, drowsiness (sleepiness), fatigue, nausea, and vomiting. Some individuals may experience behavioral or mood changes such as irritability, aggression, anxiety, depression, or agitation. Serious side effects, though rare, can include suicidal thoughts or behavior, serious allergic reactions (like swelling of the face, throat, or tongue, and difficulty breathing), and problems with coordination. Report any unusual or worsening symptoms to your doctor immediately.

Is BRIV 25 MG TABLET safe during pregnancy or breastfeeding?

BRIV 25 MG TABLET is generally not recommended for use during pregnancy, as there is limited information on its safety and potential effects on an unborn baby, and animal studies have shown potential harm. It should only be used if the potential benefits outweigh the risks, and under strict medical supervision. For breastfeeding, it is also advised to consult a doctor, as information regarding its use is limited, and it may pass into breast milk. Your doctor will help decide the best course of action.

Can BRIV 25 MG TABLET be taken with other medications?

BRIV 25 MG TABLET can interact with other medications. It is crucial to inform your doctor about all medicines, supplements, or herbal remedies you are currently taking to avoid potential interactions. For instance, other anti-epileptic medicines like carbamazepine, phenytoin, and levetiracetam may alter its effectiveness or increase side effects. Antibiotics like rifampin can decrease brivaracetam levels. Central nervous system depressants (e.g., diazepam, alprazolam) and alcohol can enhance drowsiness and cognitive impairment when combined with brivaracetam.

What precautions should be taken while using BRIV 25 MG TABLET?

Several precautions should be observed when taking BRIV 25 MG TABLET:

• Do not stop abruptly: Suddenly stopping the medication can cause seizures to worsen or return. Always consult your doctor for gradual dose reduction.
• Mental Health: Monitor for changes in mood or behavior, including depression, anxiety, agitation, aggression, or suicidal thoughts. Report any such changes to your doctor immediately.
• Driving and operating machinery: This medicine can cause sleepiness, dizziness, and problems with balance and coordination. Avoid driving or operating heavy machinery until you know how it affects you.
• Liver and Kidney problems: Inform your doctor if you have liver or kidney issues, as dose adjustments may be necessary.
• Alcohol: Avoid alcohol consumption as it can increase drowsiness and may lower the seizure threshold.

What happens if a dose of BRIV 25 MG TABLET is missed?

If you miss a dose of BRIV 25 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects.

How should BRIV 25 MG TABLET be stored?

BRIV 25 MG TABLET should be stored in a closed container at room temperature, away from heat, moisture, and direct light. It is generally recommended to store it below 25°C or 30°C and in its original packaging to protect it from moisture. Keep it out of the reach of children and pets.