Dilnip Trio 6.25 Mg Tablet (10 Tab)

DILNIP TRIO 6.25 MG TABLET

DILNIP TRIO 6.25 MG TABLET, manufactured by LUPIN LTD., is a combination medication used for the effective management of hypertension (high blood pressure) in adults. This medication works synergistically through its three active ingredients to lower blood pressure and reduce the risk of serious cardiovascular complications such as heart attack and stroke.

Composition

Each tablet of DILNIP TRIO 6.25 MG contains:

• Chlorthalidone: 6.25 mg
• Cilnidipine: 10 mg
• Telmisartan: 40 mg

Chlorthalidone is a diuretic (water pill) that aids the body in removing excess water and salts, thereby reducing blood volume and lowering blood pressure. Cilnidipine is a calcium channel blocker that relaxes and widens blood vessels. Telmisartan is an angiotensin II receptor blocker (ARB) that blocks a hormone causing blood vessel narrowing, thus relaxing and widening blood vessels to improve blood flow.

Uses

DILNIP TRIO 6.25 MG TABLET is primarily prescribed for:

• Treating essential hypertension (high blood pressure) in adults, particularly when blood pressure is not adequately controlled by a single medication.
• Reducing the risk of cardiovascular events such as heart attack and stroke.
• Managing edema (fluid retention) by facilitating the removal of excess water and salts from the body.

Dosage and Administration

The typical dosage is one tablet daily, taken orally. It is recommended to take the tablet at the same time each day for consistent effect, with or without food. Due to the diuretic component, it is advisable to avoid taking this medicine within four hours of bedtime to prevent increased urination during the night. The dosage should be as prescribed by a healthcare professional and should not be adjusted without consultation.

Side Effects

Common side effects may include:

• Dizziness, headache, tiredness, fatigue, sleepiness
• Low blood pressure
• Stomach upset, nausea
• Ankle swelling
• Palpitations (uneven heartbeat)
• Hypokalemia (low potassium levels), hyponatremia (low sodium levels), hyperuricemia (excess uric acid in blood), glucose intolerance, altered blood lipid levels, taste changes, flushing (sense of warmth)

Serious side effects are less common but may include a sudden drop in blood pressure, fainting, severe allergic reactions, increased heart rate, muscle cramps or weakness, and changes in kidney function.

Precautions

• Pregnancy and Breastfeeding: DILNIP TRIO is not recommended during pregnancy, especially in the second and third trimesters, as it may cause serious harm to the unborn baby. It is also not recommended for breastfeeding women as it may be excreted in human milk.
• Medical Conditions: Inform your doctor if you have liver, kidney, or heart problems (including low blood pressure, cardiogenic shock, myocardial infarction, acute unstable angina, aortic stenosis), diabetes, low levels of sodium or potassium, gout, kidney stones, Addison's disease, high blood levels of calcium, or elevated aldosterone levels.
• Alcohol: Avoid alcohol consumption as it may increase the risk of low blood pressure and intensify side effects like dizziness.
• Driving and Operating Machinery: This medication may cause dizziness or tiredness. Patients should avoid driving or operating heavy machinery if they experience these effects.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking to prevent potential interactions, especially with other antihypertensive agents, corticosteroids, antimanic agents (lithium), digoxin, diabetes medications (insulin, metformin), and certain pain killers.
• Children: DILNIP TRIO 6.25 MG TABLET is not recommended for children below 18 years of age.

Storage

Store in a cool and dry place, away from direct sunlight. Keep out of reach and sight of children. It is typically stored below 30ºC.

What is DILNIP TRIO 6.25 MG TABLET used for?

DILNIP TRIO 6.25 MG TABLET is primarily used to treat hypertension, also known as high blood pressure. It helps in effectively managing elevated blood pressure levels and reducing the risk of serious cardiovascular complications such as heart attack, stroke, and kidney problems. This medication is often prescribed when a single drug is not sufficient to control blood pressure.

How does DILNIP TRIO 6.25 MG TABLET work?

DILNIP TRIO 6.25 MG TABLET is a combination of three active ingredients: Chlorthalidone, Cilnidipine, and Telmisartan, each working differently to lower blood pressure.

• Chlorthalidone is a diuretic (water pill) that helps your body remove excess water and salts (like sodium and potassium) through urine, which reduces blood volume and pressure in blood vessels.
• Cilnidipine is a calcium channel blocker that relaxes and widens blood vessels by blocking calcium entry into their muscle cells, thereby improving blood flow and oxygen supply to the heart.
• Telmisartan is an angiotensin II receptor blocker (ARB) that works by blocking the action of a hormone (angiotensin II) that causes blood vessels to narrow. This leads to the widening and relaxation of blood vessels, lowering blood pressure.

What is the usual dosage of DILNIP TRIO 6.25 MG TABLET?

The typical dosage is one tablet daily, but this should be taken exactly as prescribed by your doctor. Swallow the tablet whole with a glass of water, without crushing or chewing it. For optimal effectiveness, it is recommended to take the tablet at the same time each day. It can be taken with food. Due to the diuretic component, it's advisable to avoid taking it within four hours of bedtime to prevent increased urination during the night.

What are the possible side effects of DILNIP TRIO 6.25 MG TABLET?

Common side effects may include dizziness, headache, fatigue, low blood pressure, stomach upset, ankle swelling, palpitations, nausea, sleepiness, cough, low potassium levels (hypokalemia), low sodium levels (hyponatremia), high uric acid levels (hyperuricemia), taste changes, and flushing. Most of these side effects are temporary and usually resolve over time. However, if they persist or worsen, you should consult your doctor.

Is DILNIP TRIO 6.25 MG TABLET safe during pregnancy or breastfeeding?

No, DILNIP TRIO 6.25 MG TABLET is not recommended during pregnancy, especially in the second and third trimesters, as it may cause serious harm to the unborn baby. If you become pregnant while taking this medication, discontinue it immediately and consult your doctor. It is also not recommended for use during breastfeeding because it may be excreted in human milk and could be harmful to the baby. Consult your doctor for alternative treatment options if you are breastfeeding.

Can DILNIP TRIO 6.25 MG TABLET be taken with other medications?

DILNIP TRIO 6.25 MG TABLET can interact with various medications. It is crucial to inform your doctor about all prescription and over-the-counter medicines, supplements, and herbal products you are currently taking or plan to take. Potential interactions include:

• Medicines for heart failure (e.g., digoxin).
• Diabetes medications (e.g., insulin, metformin), which may lead to low blood sugar.
• Other blood pressure-lowering medicines.
• Anti-cancer medicines (e.g., aldesleukin).
• Certain pain relievers and anti-inflammatory drugs (e.g., aspirin, NSAIDs like ibuprofen).
• Corticosteroids (e.g., hydrocortisone, prednisone), which can enhance effects leading to low potassium.
• Lithium (for psychiatric illnesses), as it may increase lithium levels in the blood.
• Strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin), which can increase the level of cilnidipine in your body.

What precautions should be taken while taking DILNIP TRIO 6.25 MG TABLET?

Before taking this medicine, inform your doctor if you have any pre-existing conditions such as heart, liver, or kidney problems, diabetes, low blood pressure, high cholesterol, gout, kidney stones, or electrolyte imbalances.

• Avoid consuming alcohol, as it can increase the risk of low blood pressure, dizziness, and fainting.
• Do not drive or operate machinery if you experience dizziness or tiredness after taking this medication.
• Avoid grapefruit or grapefruit juice, as it may increase the levels of cilnidipine in your body.
• If you have diabetes, closely monitor your blood sugar levels.
• Maintain a balanced diet, focusing on low-sodium foods, and consume high-potassium foods in moderation.
• Regular monitoring of blood pressure, kidney function, and electrolytes is essential.
• This medicine is not recommended for children under 18 years of age.

What happens if a dose of DILNIP TRIO 6.25 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should DILNIP TRIO 6.25 MG TABLET be stored?

Store DILNIP TRIO 6.25 MG TABLET in a cool and dry place, away from direct sunlight. Keep it in its original packaging to protect it from light and moisture. The ideal storage temperature is typically between 10ºC and 25ºC or below 30ºC. Always keep this medicine out of the reach and sight of children.