Name

• Brand Name: CB-Lin 0.25 mg Tablet
• Common Name: Cabergoline 0.25 mg Tablet

Composition Each uncoated tablet contains Cabergoline I.P. 0.25 mg.

Uses CB-Lin 0.25 mg Tablet is primarily used to treat hyperprolactinemia, a condition characterized by high levels of the hormone prolactin in the body. Prolactin is responsible for breast development and milk production. By reducing prolactin levels, this medicine helps to:

• Stop or suppress breast milk production after childbirth, stillbirth, abortion, or miscarriage, or if breastfeeding is not desired.
• Restore normal menstrual cycles, promote ovulation, and improve fertility in women with irregular periods caused by high prolactin levels.
• Manage galactorrhea (secretion of breast milk without pregnancy or breastfeeding) and idiopathic hyperprolactinemia (elevated prolactin levels with no known cause).
• Address high prolactin levels due to pituitary gland tumors in both men and women, and can also alleviate decreased libido and erectile dysfunction in men caused by elevated prolactin.
• A higher dose of cabergoline (1mg) is also used as a second-line treatment for Parkinson's disease.

Dosage and Administration CB-Lin 0.25 mg Tablet should be taken as advised by your physician. It is typically taken orally, usually once or twice weekly. The tablets should be swallowed whole with water and not crushed or chewed. It can be taken with or after food to help reduce feelings of nausea or vomiting. Your doctor will determine the correct dose and duration based on your age, body weight, and medical condition. Do not stop taking the medicine unless your doctor tells you to do so.

Side Effects Common Side Effects:

• Drowsiness, headache
• Nausea, vomiting, stomach pain, indigestion, constipation
• Dizziness, vertigo
• Fatigue, lack of bodily strength, weakness
• Blurred vision
• Low blood pressure (which can result in dizziness upon standing)
• Breast pain
• Hot flushes
• Depression, sleep disturbances

Serious Side Effects (Contact your doctor immediately if you experience):

• Abnormal or unusual thoughts
• Heart valve and related disorders (e.g., inflammation of the heart or fluid leakage in the pericardium), with symptoms like difficulty breathing, shortness of breath, pounding heart, feeling faint, chest pain, back pain, pelvic pain, or swollen legs. These may be signs of pulmonary fibrosis.

Precautions

• Pregnancy: Not recommended during pregnancy, as there is evidence of risk to the developing baby. Women should use other forms of contraception and avoid pregnancy for at least one month after stopping the drug.
• Breastfeeding: Not recommended for use in breastfeeding women as it stops milk production and may be unsafe for the baby.
• Children: Not recommended for use in children under 16 years of age.
• Liver Disease: Use with caution in patients with reduced liver function or severe liver disease; dose adjustment may be necessary.
• Heart Conditions: Not recommended for patients with stiff and inflamed heart valves (cardiac valvulopathy), uncontrolled high blood pressure, or a history of fibrotic reactions affecting the heart or lungs. Use with caution in patients with cardiovascular diseases or low blood pressure. Regular blood pressure monitoring may be advised.
• Mental Illness: Use with caution in patients with a history of mental illness, as it can worsen symptoms.
• Driving and Operating Machinery: CB-Lin 0.25 mg Tablet can cause dizziness and drowsiness, so avoid driving or operating heavy machinery if you experience these effects.
• Alcohol: Caution is advised when consuming alcohol, as it may increase the risk of side effects like dizziness and drowsiness.
• Drug Interactions: Inform your doctor about all other medications you are taking to prevent potential interactions.

Storage Store CB-Lin 0.25 mg Tablet in a cool and dry place, protected from direct sunlight, moisture, and heat. Keep it out of sight and reach of children and pets. Store below 25°C or below 30°C.

CB LIN 0.25 MG TABLET (Cabergoline) - Frequently Asked Questions

CB LIN 0.25 MG TABLET, containing cabergoline, is a medication primarily used to manage conditions related to high levels of prolactin, a hormone produced by the pituitary gland. It works by mimicking the action of dopamine in the brain, which helps to reduce prolactin secretion.

What is CB LIN 0.25 MG TABLET used for?

CB LIN 0.25 MG TABLET is primarily used to treat hyperprolactinemia, a condition characterized by abnormally high levels of the hormone prolactin in the body. This can lead to various issues such as irregular menstrual cycles, infertility, and abnormal breast milk secretion (galactorrhea) in women, and breast enlargement and sexual dysfunction in men. It is also used to stop or suppress breast milk production after stillbirth, abortion, miscarriage, or if breastfeeding is not desired after delivery. In some cases, higher doses of cabergoline may be used as a second-line treatment for Parkinson's disease.

How does CB LIN 0.25 MG TABLET work?

CB LIN 0.25 MG TABLET contains cabergoline, which is a dopamine agonist. It works by stimulating D2 receptors on the lactotroph cells in the anterior pituitary gland, which are responsible for producing prolactin. By doing so, it effectively inhibits the synthesis and secretion of prolactin, leading to a decrease in prolactin levels in the body.

What is the usual dosage of CB LIN 0.25 MG TABLET?

The recommended starting dosage for CB LIN 0.25 MG TABLET is typically 0.25 mg taken twice per week. Your doctor may gradually increase the dosage by 0.25 mg at intervals of no less than 4 weeks, depending on your prolactin levels and response to treatment. The maximum recommended dosage is usually 1 mg twice weekly. It can be taken with or without food, but taking it with or after food may help reduce nausea.

What are the possible side effects?

Common side effects of CB LIN 0.25 MG TABLET can include drowsiness, nausea, headache, dizziness, vertigo, stomach pain, indigestion, constipation, fatigue, weakness, and hot flashes. Other possible side effects include blurred vision, breast pain, depression, and low blood pressure (especially upon standing).

Serious but rare side effects can include abnormal thoughts, heart valve and related disorders (like inflammation of the heart or fluid leakage in the pericardium), which may present as difficulty breathing, shortness of breath, pounding heart, chest pain, or swollen legs. It's important to consult your doctor if any side effects worsen or if you experience any serious or unusual symptoms.

Is it safe during pregnancy or breastfeeding?

CB LIN 0.25 MG TABLET is generally not recommended for use in pregnant women, and you should take precautions to avoid pregnancy for at least one month after stopping the medication. If you become pregnant during treatment, stop the medicine and contact your doctor, who will monitor your pregnancy due to the potential for congenital abnormalities.

It is also not recommended for use in breastfeeding women as it can stop or suppress milk production.

Can it be taken with other medications?

Inform your doctor about all medicines you are currently taking, including over-the-counter drugs and herbal supplements, as CB LIN 0.25 MG TABLET can interact with certain medications.

Some medications that may interact with CB LIN 0.25 MG TABLET include:

• Medicines for mental illness (e.g., chlorpromazine, haloperidol, risperidone, quetiapine) as they can counteract the effects of cabergoline.
• Medicines for nausea and vomiting (e.g., domperidone, metoclopramide) which may reduce its effectiveness.
• Medicines for Parkinson's disease (e.g., Levodopa, bromocriptine).
• Medicines for severe migraine headaches (e.g., pergolide, bromocriptine, lisuride, ergotamine).
• Macrolide antibiotics (e.g., erythromycin) which can increase cabergoline levels in the body.
• Medicines to lower blood pressure (e.g., amlodipine, lisinopril, metoprolol) as concomitant use can enhance blood pressure-lowering effects.

What precautions should be taken?

Before taking CB LIN 0.25 MG TABLET, inform your doctor if you have any of the following:

• Severe liver disease or reduced liver function.
• Stiff and inflamed heart valves (cardiac valvulopathy) or a history of fibrotic reactions (scar tissue) affecting the abdomen, heart, or lungs.
• Uncontrolled high blood pressure, especially high blood pressure during pregnancy (preeclampsia, eclampsia).
• History of mental illness, especially associated with childbirth.
• Kidney problems.
• Cardiovascular diseases or low blood pressure.
• Pain in the chest while breathing, fluid in the lungs, or inflammation/infection of the lungs.

Avoid driving or operating machinery if you experience dizziness or sleepiness. Alcohol consumption should be avoided as it may worsen side effects like dizziness and drowsiness. Regular monitoring of blood pressure and heart function (including echocardiograms) may be advised during treatment.

What happens if a dose is missed?

If you miss a dose of CB LIN 0.25 MG TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should it be stored?

Store CB LIN 0.25 MG TABLET in a cool, dry place at room temperature (below 25°C), away from direct sunlight, moisture, and heat. Keep it out of sight and reach of children and pets.