Pyrigesic Sp Tab

PYRIGESIC SP TAB

Name

Common Name: Pyrigesic SP Tablet Brand Name: PYRIGESIC SP TAB by EAST INDIA PHARMACEUTICAL DIV-2

Composition

Pyrigesic SP Tablet is a fixed-dose combination medication containing three active ingredients:

• Aceclofenac: 100 mg
• Paracetamol (Acetaminophen): 325 mg
• Serratiopeptidase: 15 mg (equivalent to 30,000 IU)

Uses

Pyrigesic SP Tablet is primarily used for the reduction of pain, inflammation, and swelling. It is prescribed for a variety of conditions, including:

• Pain and inflammation due to bone or soft tissue injury.
• Resolution of postoperative inflammation and oedema (swollen tissue with fluid).
• Musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
• Relief from low back pain, dental pain, and dysmenorrhea (menstrual pain).
• Fever reduction, due to the antipyretic action of paracetamol.

Dosage and Administration

Pyrigesic SP Tablet should be taken in the dose and duration advised by a healthcare professional.

• Swallow the tablet whole with a glass of water. Do not chew, crush, or break it.
• It is generally recommended to take this medicine with food or milk to minimize potential stomach upset.
• Do not exceed the recommended dose or duration of treatment.

Side Effects

Most side effects are temporary and resolve over time. Common side effects may include:

• Nausea, vomiting
• Stomach pain, abdominal pain
• Indigestion, heartburn, dyspepsia
• Loss of appetite
• Diarrhea
• Dizziness, drowsiness
• Increased liver enzymes

Serious side effects, especially with long-term use, can include stomach bleeding and kidney problems.

Precautions

• Allergies: Do not take if allergic to aceclofenac, paracetamol, serratiopeptidase, or other NSAIDs like aspirin or ibuprofen.
• Pregnancy and Breastfeeding: Not recommended during the last trimester of pregnancy and should be used with caution during other trimesters. Information on use during breastfeeding is limited; consult a doctor.
• Alcohol: Avoid alcohol consumption as it may increase the risk of liver damage.
• Medical Conditions: Use with caution in patients with kidney or liver disease, heart conditions (like severe heart failure or high blood pressure), stomach ulcers, or gastric bleeding. Patients with severe liver disease should avoid it.
• Driving: May cause dizziness or drowsiness, so avoid driving or operating heavy machinery if affected.
• Drug Interactions: Inform your doctor about all other medications, supplements, or herbals being taken to avoid potential interactions (e.g., mifepristone, leflunomide, ketoconazole). Do not take with other medicines containing acetaminophen without consulting a doctor.
• Children: Not recommended for use in children as safety and efficacy have not been established.

Storage

Store in a cool and dry place, away from direct sunlight and moisture. Keep out of sight and reach of children. The typical storage temperature is below 25°C or 30°C.

1. What is PYRIGESIC SP TAB used for?

PYRIGESIC SP TAB is a combination medicine primarily used for the short-term relief of pain, inflammation, and swelling associated with various musculoskeletal conditions. It is effective in managing conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, low back pain, dental pain, dysmenorrhea (menstrual pain), and post-operative pain. It can also help reduce fever.

2. How does PYRIGESIC SP TAB work?

PYRIGESIC SP TAB contains three active ingredients: Aceclofenac, Paracetamol (Acetaminophen), and Serratiopeptidase.

• Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the action of cyclooxygenase-2 (COX-2) enzymes, which are responsible for producing prostaglandins that cause pain, inflammation, and fever.
• Paracetamol acts as an analgesic (pain reliever) and antipyretic (fever reducer) by changing how the body senses pain and cooling down the body, thereby enhancing the pain relief action of aceclofenac.
• Serratiopeptidase is an enzyme that helps reduce inflammation and swelling by breaking down abnormal proteins at the site of inflammation and promoting healing. It also aids in thinning fluids around the injury site, facilitating smoother fluid drainage in swollen tissue.

3. What is the usual dosage of PYRIGESIC SP TAB?

The dosage and duration of PYRIGESIC SP TAB should be advised by your doctor. It should be swallowed whole with a glass of water, without crushing or chewing. It is recommended to take this medicine with food or milk to minimize potential stomach upset. Do not exceed the recommended dose or duration of treatment.

4. What are the possible side effects of PYRIGESIC SP TAB?

Common side effects of PYRIGESIC SP TAB may include abdominal pain, dyspepsia (indigestion), nausea, vomiting, diarrhea, flatulence, rash, heartburn, loss of appetite, dizziness, drowsiness, and increased liver enzymes. If symptoms persist or cause concern, it is important to consult your doctor.

5. Is PYRIGESIC SP TAB safe during pregnancy or breastfeeding?

PYRIGESIC SP TAB is generally not recommended for use during pregnancy, especially in the last trimester, unless specifically advised by a doctor after assessing the potential benefits and risks. It is also not advised for women who are breastfeeding, and a doctor should be consulted for safer alternatives.

6. Can PYRIGESIC SP TAB be taken with other medications?

PYRIGESIC SP TAB can interact with several medications.

• Anticoagulants and anti-platelet agents (e.g., warfarin, heparin, clopidogrel): Increased risk of gastrointestinal bleeding.
• Other NSAIDs (e.g., ibuprofen, naproxen): Can intensify the risk of stomach ulcers and bleeding.
• Medicines containing paracetamol or aceclofenac: Should not be taken concurrently to avoid overdose and potential liver damage.
• Lithium: Can increase lithium levels in the blood, leading to toxicity.
• Methotrexate: Can increase methotrexate toxicity.
• Diuretics and Antihypertensive drugs: Aceclofenac can reduce their effectiveness and increase the risk of kidney damage.
• Corticosteroids: Increased risk of gastrointestinal bleeding and ulcers. It is important to inform your doctor about all medicines, supplements, or herbal products you are currently taking to avoid potential interactions.

7. What precautions should be taken while using PYRIGESIC SP TAB?

Several precautions should be observed when taking PYRIGESIC SP TAB:

• Allergies: Do not take if you have a known allergy to aceclofenac, paracetamol, serratiopeptidase, or any other components of the tablet, or if you have a history of severe allergic reactions to painkillers like aspirin or ibuprofen.
• Pre-existing conditions: Exercise caution if you have stomach ulcers, gastric bleeding, severe heart failure, high blood pressure, or liver or kidney disease. Regular monitoring of kidney and liver function may be necessary during long-term treatment.
• Alcohol: Avoid consuming alcohol, as it can increase the risk of liver damage and stomach irritation.
• Driving/Operating machinery: This medicine may cause dizziness or drowsiness, so avoid driving or activities requiring mental focus until you know how it affects you.
• Children and Elderly: Not recommended for children under 18 years of age. Older patients should use it under medical supervision due to increased susceptibility to side effects.

8. What happens if a dose is missed?

If you miss a dose of PYRIGESIC SP TAB, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

9. How should PYRIGESIC SP TAB be stored?

PYRIGESIC SP TAB should be stored at cool room temperature, ideally below 30°C (or between 10-30°C). Keep it in a dry place, shielded from direct light and moisture. Always keep it out of the reach of children. Ensure the medicine is used before its expiry date.