Dapanorm-l 10 (10 Tablet)

DAPANORM-L 10 Tablet

DAPANORM-L 10 Tablet, manufactured by Alkem Laboratories Ltd, is a combination medication used for the management of Type 2 Diabetes Mellitus in adults.

• Composition

  • DAPANORM-L 10 contains two active ingredients: Dapagliflozin (10 mg) and Linagliptin (5 mg).
  • Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT2) inhibitor that works by increasing the removal of excess glucose from the body through urine via the kidneys.
  • Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps regulate blood sugar by increasing the levels of natural substances called incretins, which stimulate insulin release and decrease glucagon production, particularly after meals.

• Uses DAPANORM-L 10 Tablet is prescribed for:

  • Controlling high blood sugar levels in adults with Type 2 Diabetes Mellitus.
  • Improving glycemic control alongside a balanced diet and regular exercise.
  • Reducing the risk of serious diabetes complications such as kidney damage, eyesight loss (retinopathy), nerve damage (neuropathy), heart attack, and stroke.
  • Cardiovascular and kidney protection: It helps reduce the risk of heart failure and kidney complications associated with diabetes.

• Dosage and Administration

  • DAPANORM-L 10 Tablet should be taken orally once daily, preferably in the morning, with or without food.
  • Swallow the tablet whole with a glass of water; do not crush or chew it.
  • It is important to take the medicine at the same time each day to help with adherence.
  • The dose and duration of treatment are determined by your doctor based on your medical condition and response. Do not stop taking the medication without consulting your doctor, as abrupt discontinuation can lead to increased blood sugar levels and potential complications.

• Side Effects Common side effects may include:

  • Hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines, alcohol, or if meals are delayed or missed.
  • Urinary tract infections (UTIs)
  • Genital infections such as vulvovaginitis and balanitis.
  • Nasopharyngitis (inflammation of the throat and nasal passages).
  • Headache, dizziness, nausea, vomiting, diarrhea, and back pain. Serious but less common side effects include diabetic ketoacidosis and necrotizing fasciitis of the perineum (Fournier's Gangrene).

• Precautions

  • Inform your doctor if you have any allergies to dapagliflozin, linagliptin, or any other ingredients.
  • This medicine is not recommended for patients with Type 1 Diabetes Mellitus, diabetic ketoacidosis, or severe kidney or liver disease.
  • Use with caution if you have heart failure, low blood pressure, or a history of urinary tract or genital fungal infections.
  • Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.
  • Limit or avoid alcohol consumption, as it can increase the risk of hypoglycemia and other side effects.
  • Be aware of potential drug interactions with insulin, sulfonylureas, diuretics, rifampin, digoxin, and certain other medications. Inform your doctor about all medicines you are taking.
  • Regular monitoring of blood sugar levels and kidney function is advised during treatment.

• Storage

  • Store DAPANORM-L 10 Tablets in a cool and dry place, away from direct sunlight and moisture.
  • Maintain storage temperature below 30°C (10°C to 25°C).
  • Keep out of the sight and reach of children.

Here are frequently asked questions (FAQs) about DAPANORM-L 10 (10 TABLET) by ALKEM LABORATORIES LTD:

What is DAPANORM-L 10 used for?

DAPANORM-L 10 is a combination medicine primarily used for the management of type 2 diabetes mellitus in adults. It is typically prescribed when blood sugar levels are not adequately controlled with metformin alone or other first-line treatments. It helps to control high blood sugar levels and can also help reduce the risk of serious complications associated with diabetes, such as kidney damage, vision loss, nerve damage, heart attack, and stroke. It may also offer cardiovascular and kidney protection.

How does DAPANORM-L 10 work?

DAPANORM-L 10 contains two active ingredients: Dapagliflozin and Linagliptin. Dapagliflozin belongs to a class of medicines called SGLT2 inhibitors. It works by inhibiting a protein in the kidneys called sodium-glucose co-transporter 2, which helps reabsorb glucose back into the bloodstream. By blocking this, Dapagliflozin causes excess glucose to be removed from the body through urine, thereby lowering blood sugar levels. Linagliptin is a DPP-4 inhibitor. It works by increasing the levels of natural substances in the body called incretins, which help to regulate blood sugar. Incretins stimulate the release of insulin after meals and reduce the amount of sugar produced by the liver, contributing to better blood sugar control.

What is the usual dosage for DAPANORM-L 10?

DAPANORM-L 10 is typically taken once daily. It can be taken with or without food, but it is recommended to take it at the same time each day to maintain consistent blood sugar levels. The exact dose and duration of treatment will be determined by your doctor based on your individual condition and response to the medication.

What are the possible side effects of DAPANORM-L 10?

Common side effects of DAPANORM-L 10 may include hypoglycemia (low blood sugar), urinary tract infections (UTIs), genital fungal infections (like vulvovaginitis or balanitis), nasopharyngitis (inflammation of the throat and nasal passages), dizziness, rash, and back pain. Serious but rare side effects like diabetic ketoacidosis and necrotizing fasciitis of the perineum (Fournier's Gangrene) have also been reported. If any side effects worsen or if you experience severe symptoms, consult your doctor immediately.

Is DAPANORM-L 10 safe during pregnancy or breastfeeding?

DAPANORM-L 10 is not recommended for use during pregnancy as it may produce harmful effects on the fetus. It is also not recommended for breastfeeding women, as it is not known whether it passes into breast milk. It is crucial to consult your doctor if you are pregnant, think you may be pregnant, are planning to have a baby, or are breastfeeding.

Can DAPANORM-L 10 be taken with other medications?

DAPANORM-L 10 can interact with certain medications. Inform your doctor about all medicines, supplements, or herbal products you are currently taking. Particular caution is advised with:

• Insulin or sulfonylureas (other diabetes medications), as this combination can increase the risk of hypoglycemia (low blood sugar). Dosage adjustments may be needed.
• Diuretics (medicines that increase urine production), as Dapagliflozin can increase the risk of dehydration and low blood pressure.
• Rifampin (used for tuberculosis) and other strong CYP3A4 inducers, which may reduce the effectiveness of Linagliptin.
• Digoxin (for heart failure) and topiramate or other carbonic anhydrase inhibitors (for fits and glaucoma).

What precautions should be taken while using DAPANORM-L 10?

DAPANORM-L 10 should be used with caution in patients with liver disease, moderate to severe kidney disease, heart failure, or a history of low blood pressure. Patients with urinary tract infections or genital fungal infections should also be cautious, as this medicine can worsen these conditions. It is important to stay well-hydrated, especially with Dapagliflozin increasing urination. Regular monitoring of blood sugar levels and kidney function is essential. Avoid excessive alcohol consumption as it may increase the risk of hypoglycemia and other side effects.

What happens if a dose is missed?

If you miss a dose of DAPANORM-L 10, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should DAPANORM-L 10 be stored?

DAPANORM-L 10 should be kept out of the sight and reach of children. Store it below 30°C, away from direct sunlight and moisture.