Istamet 50/1000 Mg(2x15t)

ISTAMET 50/1000 MG Tablet

Name

• Brand Name: ISTAMET 50/1000 MG
• Common Name: Sitagliptin and Metformin Hydrochloride Tablets

Composition

Each tablet contains:

• Sitagliptin: 50 mg
• Metformin Hydrochloride: 1000 mg

Uses

ISTAMET 50/1000 MG is a combination medication primarily used for the management of Type 2 Diabetes Mellitus in adults. It helps to control high blood sugar levels when diet and exercise alone are not sufficient. By improving glycemic control, it aids in preventing serious complications associated with diabetes, such as kidney damage, blindness, nerve problems, and cardiovascular risks like heart attack or stroke.

Dosage and Administration

• ISTAMET 50/1000 MG tablets are typically taken orally, once or twice daily.
• It should be taken with meals to reduce the chance of stomach upset.
• Tablets should be swallowed whole with a glass of water and not crushed, chewed, or broken.
• The exact dosage is determined by a healthcare professional based on individual needs, blood sugar levels, and other medications being taken.
• For optimal benefits, take the medication regularly at the same time each day and do not discontinue without consulting your doctor.

Side Effects

Common Side Effects:

• Nausea, vomiting, diarrhea, stomach pain
• Headache
• Upper respiratory tract infection
• Hypoglycemia (low blood sugar), especially when used with other antidiabetic medications
• Metallic taste, dry mouth, flatulence, constipation, loss of appetite

Serious but Rare Side Effects:

• Lactic Acidosis (a medical emergency caused by increased lactic acid in the blood)
• Vitamin B12 deficiency with long-term use
• Pancreatitis (inflammation of the pancreas)

Precautions

• Contraindications: Do not take if allergic to Sitagliptin or Metformin. Not recommended for patients with Type 1 Diabetes Mellitus, severe kidney or liver disease, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.
• Alcohol Consumption: Avoid or limit alcohol intake as it can increase the risk of lactic acidosis and hypoglycemia.
• Pregnancy and Breastfeeding: Consult a doctor. Caution is advised, and it should be used only if the benefits outweigh the risks.
• Drug Interactions: Inform your doctor about all other medications, including cationic medications (e.g., amiloride, trimethoprim), diuretics, corticosteroids, and thyroid medications, as they may interact with ISTAMET.
• Monitoring: Regular monitoring of kidney function, blood sugar levels, and thyroid-stimulating hormone (TSH) is recommended during treatment.
• Pancreatitis: Use with caution in patients with a history of acute pancreatitis.

Storage

• Store at room temperature, ideally between 15 to 30°C.
• Keep it away from direct sunlight and damp areas.
• Ensure it is out of sight and reach of children.
• Always check the expiry date before use.

What is ISTAMET 50/1000 MG used for?

ISTAMET 50/1000 MG is a combination medication primarily used to manage high blood sugar levels in adults with Type 2 Diabetes Mellitus. It is prescribed alongside a healthy diet and regular exercise to improve blood sugar control. By effectively managing diabetes, it helps reduce the risk of serious complications such as kidney damage, blindness, nerve problems, heart attack, and stroke.

How does ISTAMET 50/1000 MG work?

This medicine contains two active ingredients: Sitagliptin (50 mg) and Metformin (1000 mg). Sitagliptin is a DPP-4 inhibitor that works by increasing the levels of natural substances called incretins. These incretins help the pancreas produce more insulin, especially after meals, and decrease the amount of sugar produced by the liver. Metformin, a biguanide, reduces glucose production in the liver, delays the absorption of glucose from the intestines, and improves the body's sensitivity to insulin. Together, these actions help to achieve better control over blood sugar levels.

What is the usual dosage for ISTAMET 50/1000 MG?

ISTAMET 50/1000 MG is typically taken once or twice a day with meals to minimize stomach upset. It is important to swallow the tablet whole and not to crush or chew it. Your doctor will determine the appropriate dosage based on your individual condition, blood sugar levels, and any other medications you may be taking. The daily dose usually does not exceed 100 mg of sitagliptin and 2000 mg of metformin.

What are the possible side effects of ISTAMET 50/1000 MG?

Common side effects may include nausea, vomiting, diarrhea, abdominal pain, headache, upper respiratory tract infection, metallic taste, flatulence, and loss of appetite. Low blood sugar (hypoglycemia) can also occur, especially if taken with other diabetes medications. More serious, though rare, side effects can include lactic acidosis (symptoms like muscle pain, difficulty breathing, severe tiredness, stomach pain), pancreatitis, or severe allergic skin reactions. If you experience persistent or worsening side effects, consult your doctor.

Is ISTAMET 50/1000 MG safe during pregnancy or breastfeeding?

ISTAMET 50/1000 MG is generally not recommended during pregnancy or while breastfeeding. If you are pregnant, planning a pregnancy, or breastfeeding, you should consult your doctor to discuss safer alternative treatments.

Can ISTAMET 50/1000 MG be taken with other medications?

ISTAMET 50/1000 MG can be prescribed alone or in combination with other diabetes medications. However, caution is advised when taking it with other antidiabetic agents like insulin or sulfonylureas, as this may increase the risk of low blood sugar. Certain medications, such as ACE inhibitors, corticosteroids, thiazide diuretics, and thyroid hormones, can also interact with ISTAMET, potentially affecting kidney function or blood sugar control. Always inform your doctor about all prescription drugs, over-the-counter medications, supplements, and herbal products you are taking to avoid potential interactions.

What precautions should be taken while using ISTAMET 50/1000 MG?

It is important to avoid alcohol consumption while taking ISTAMET 50/1000 MG, as it can increase the risk of lactic acidosis and low blood sugar. This medicine is not suitable for individuals with Type 1 diabetes, diabetic ketoacidosis, or severe kidney, liver, or heart conditions (especially heart failure). Regular monitoring of kidney function and blood sugar levels is recommended. If you are scheduled for surgery or any procedure involving iodinated contrast media, inform your doctor as the medication may need to be temporarily discontinued. If you experience dizziness or drowsiness, avoid driving or operating heavy machinery.

What happens if a dose of ISTAMET 50/1000 MG is missed?

If you miss a dose of ISTAMET 50/1000 MG, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should ISTAMET 50/1000 MG be stored?

ISTAMET 50/1000 MG should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it in its original container and out of the sight and reach of children and pets.