Carbophage G1 Tablet

CARBOPHAGE G1 TABLET by MERCK LTD

CARBOPHAGE G1 TABLET is a combination medication designed to manage Type 2 Diabetes Mellitus in adults. It is manufactured by Merck Ltd..

• Composition Each tablet contains:

  • Glimepiride (1 mg)
  • Metformin (500 mg)

• Uses CARBOPHAGE G1 TABLET is prescribed for the management of Type 2 Diabetes Mellitus in adults, particularly when diet, exercise, and single-agent medications do not achieve adequate glycemic control. It helps to lower blood sugar levels by increasing insulin release from the pancreas and reducing glucose production in the liver, while also improving the body's sensitivity to insulin. This helps reduce the risk of diabetes-related complications such as kidney damage, eye problems, nerve issues, and cardiovascular events.

• Dosage and Administration This medicine should be taken orally as directed by a healthcare professional, typically once a day, preferably with a meal. Tablets should be swallowed whole and not crushed or chewed. It is crucial not to exceed the prescribed dosage or discontinue the medication without consulting a doctor.

• Side Effects

  • Common Side Effects: Taste disturbance, diarrhea, stomach pain, nausea, vomiting, headache, loss of appetite, and hypoglycemia (low blood sugar levels).
  • Serious Side Effects (rare): Lactic acidosis, inflammation of the liver (which may cause jaundice), severe allergic reactions, and severe hypoglycemia. Long-term use may also lead to Vitamin B12 deficiency.

• Precautions CARBOPHAGE G1 TABLET is contraindicated in pregnant or breastfeeding women, individuals with severe kidney or liver disease, Type 1 Diabetes Mellitus, diabetic ketoacidosis, metabolic acidosis, severe infections, or known allergy to its components. Alcohol consumption should be avoided as it increases the risk of lactic acidosis and can affect blood sugar levels. Caution is advised for patients with kidney or liver problems, and dose adjustments may be necessary. Patients should inform their doctor about all other medications being taken, including other antidiabetic agents, anticoagulants, NSAIDs, corticosteroids, and certain blood pressure medications, as interactions can occur. Regular monitoring of blood sugar levels is important, and a fast-acting glucose source should be kept readily available to manage hypoglycemia.

• Storage Store CARBOPHAGE G1 TABLET in a cool, dry place, protected from direct sunlight and moisture, at a temperature below 30°C. Keep it out of reach and sight of children, and always check the expiry date before use.

Here are some frequently asked questions about Carbophage G1 Tablet:

What is Carbophage G1 Tablet used for?

Carbophage G1 Tablet is primarily used to manage Type 2 Diabetes Mellitus in adults, especially when diet and exercise alone, or a single anti-diabetic agent, are not sufficient to control blood sugar levels. It helps to lower elevated blood glucose and can prevent serious complications associated with diabetes, such as kidney damage, blindness, nerve problems, and reduce the risk of cardiovascular events like heart attacks and strokes.

How does Carbophage G1 Tablet work?

Carbophage G1 Tablet contains two active ingredients: Glimepiride and Metformin. Glimepiride, a sulfonylurea, works by stimulating the beta cells in the pancreas to produce and release more insulin, which helps lower blood sugar. Metformin, a biguanide, reduces the amount of glucose produced by the liver, delays the absorption of sugar from the intestines, and increases the body's sensitivity to insulin, allowing cells to use insulin more effectively to remove sugar from the blood.

What is the usual dosage of Carbophage G1 Tablet?

The dosage of Carbophage G1 Tablet is determined by your doctor based on your condition and response to treatment. It is usually taken once daily with a meal, preferably with the first meal of the day or during your evening meal. It's crucial to take the tablet as prescribed by your physician, swallowing it whole without crushing or chewing. Do not exceed the recommended dose.

What are the possible side effects of Carbophage G1 Tablet?

Common side effects may include hypoglycemia (low blood sugar), stomach pain, nausea, vomiting, diarrhea, headache, and a metallic taste. Less common but serious side effects can include lactic acidosis (a rare but severe buildup of lactic acid in the blood), and on long-term use, it may lead to Vitamin B12 deficiency. Symptoms of lactic acidosis can include muscle pain, weakness, dizziness, difficulty breathing, and stomach pain. Hypoglycemia symptoms include sweating, dizziness, headache, shaking, intense thirst, and confusion. If you experience severe or persistent side effects, or symptoms of lactic acidosis or severe hypoglycemia, seek immediate medical attention.

Is Carbophage G1 Tablet safe during pregnancy or breastfeeding?

Carbophage G1 Tablet is generally not recommended during pregnancy as it may harm the unborn baby. It is also advised to avoid it during breastfeeding, as the medicine may pass into breast milk and potentially cause adverse effects in the baby. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding before taking this medication.

Can it be taken with other medications?

Carbophage G1 Tablet can interact with various medications. Other anti-diabetic drugs (like insulin or gliclazide) or ACE inhibitors (like enalapril or losartan) may enhance its blood sugar-lowering effect, increasing the risk of hypoglycemia. Thiazides and corticosteroids (like hydrochlorothiazide or prednisolone) might reduce its efficacy. H2 blockers (like cimetidine) can increase metformin levels, while carbonic anhydrase inhibitors (like acetazolamide) can increase the risk of lactic acidosis. Always inform your doctor about all medications, supplements, and herbal products you are taking to prevent potential interactions.

What precautions should be taken?

Avoid alcohol consumption while taking Carbophage G1 Tablet, as it can increase the risk of low blood sugar and a serious condition called lactic acidosis. Patients with severe kidney or liver disease, type 1 diabetes mellitus, or diabetic ketoacidosis should not take this medicine. Caution is advised for patients with heart disease. Regular monitoring of blood sugar levels is important, and always carry a quick source of sugar (like glucose tablets or juice) to manage hypoglycemia. Your ability to drive may be affected if your blood sugar is too low or too high, so exercise caution.

What happens if a dose is missed?

If you miss a dose of Carbophage G1 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for a missed one, as this can lead to dangerously low blood sugar levels (hypoglycemia).

How should it be stored?

Carbophage G1 Tablet should be stored in a cool and dry place, away from direct sunlight, and below 30°C. Keep it in its original packaging and out of the reach and sight of children and pets. Always check the expiry date before use.