Paliris La 100mg

PALIRIS LA 100mg Injection

Name:

• Brand Name: Paliris LA
• Common Name: Paliperidone Palmitate (long-acting injection)
• Manufacturer: Sun Pharmaceutical Industries Ltd.

Composition: Paliris LA 100mg Injection contains Paliperidone 100mg as its active ingredient. Paliperidone is an atypical antipsychotic that works by balancing the levels of chemical messengers, specifically dopamine and serotonin, in the brain. This action helps to improve mood, thoughts, and behavior.

Uses: Paliris LA 100mg Injection is prescribed for adults for the treatment of:

• Schizophrenia
• Schizoaffective disorder
• Mania associated with bipolar disorder

It helps in managing symptoms such as hallucinations, delusions, disorganized thinking, confusion, disturbing thoughts, and mood swings, ultimately aiming to improve the patient's quality of life.

Dosage and Administration: Paliris LA 100mg Injection is administered as an intramuscular injection only and should be given by experienced healthcare professionals. The specific dosage and frequency are determined by the doctor based on the patient's condition and response to treatment. It is recommended to receive the injection regularly and at the same time each day (or month, depending on the dosing schedule) to maintain consistent medicine levels in the body. This medication should not be self-administered.

Side Effects: Common side effects include:

• Injection site reactions (pain, swelling, redness)
• Sleepiness or drowsiness
• Dizziness
• Restlessness or feeling the need to be constantly moving (akathisia)
• Abnormal muscle movements, including tremors (shaking) and involuntary movements
• Weight gain

Serious side effects, though less common, can include Neuroleptic Malignant Syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness. Discontinue the medicine immediately and seek medical attention if NMS occurs. Elderly patients with dementia-related psychosis may have an increased risk of stroke.

Precautions:

• Inform your doctor if you have a known hypersensitivity to paliperidone, risperidone, or any other ingredients in the formulation.
• Avoid consuming alcohol as it can increase drowsiness and dizziness.
• Exercise caution when driving or operating heavy machinery, as this medicine may impair judgment and concentration.
• Regular monitoring of weight, blood sugar, cholesterol, and triglyceride levels is advised, as this medication can affect these parameters.
• Do not stop taking Paliris LA suddenly without consulting your doctor, as this may lead to a worsening of symptoms.
• Use with caution in patients with kidney or severe liver disease; dose adjustments may be necessary.
• Not recommended for use in children.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the use of this medicine in these conditions requires careful consideration of benefits and potential risks.

Storage: Store Paliris LA 100mg Injection in a cool and dry place, away from direct sunlight. It should be kept out of the sight and reach of children. The product can be stored in cool places at 10°C to 25°C or below 30°C.

Here are some frequently asked questions about PALIRIS LA 100MG by SUN - MILMET, containing Paliperidone:

What is PALIRIS LA 100MG used for?

PALIRIS LA 100MG is an atypical antipsychotic primarily used for the treatment of schizophrenia and schizoaffective disorder in adults. It also helps manage symptoms of mania associated with bipolar disorder. This medication helps control symptoms like hallucinations, delusions, mood swings, and disorganized thinking.

How does PALIRIS LA 100MG work?

PALIRIS LA 100MG contains Paliperidone, which works by affecting the levels of chemical messengers, specifically dopamine and serotonin, in the brain. By blocking or modulating their effects, it helps improve mood, thoughts, and behavior, thereby alleviating the symptoms of the disease and preventing their recurrence.

What is the usual dosage for PALIRIS LA 100MG?

PALIRIS LA 100MG is administered as an intramuscular injection by a healthcare professional. It is not for self-administration. The dosage and frequency are determined by your doctor based on the severity of your condition and your response to treatment. For initiation, doses might be 150 mg on Day 1 and 100 mg one week later, administered in the deltoid muscle. Thereafter, maintenance doses are typically given monthly into either the deltoid or gluteal muscle, with a recommended monthly dose often around 75 mg, ranging from 25 mg to 150 mg depending on individual needs.

What are the possible side effects of PALIRIS LA 100MG?

Common side effects can include injection site reactions (such as pain, swelling, or redness), sleepiness or drowsiness, feeling restless or needing to be constantly moving, dizziness, and abnormal muscle movements including tremors (shaking), uncontrolled involuntary movements, and involuntary eye movements (nystagmus). Other common side effects may include headache, weight gain, increased blood sugar, cholesterol, and triglycerides. Serious side effects, though rare, can include Neuroleptic Malignant Syndrome (NMS), characterized by fever, muscle rigidity, and altered consciousness, and an increased risk of stroke in elderly patients with dementia-related psychosis.

Is PALIRIS LA 100MG safe during pregnancy or breastfeeding?

PALIRIS LA 100MG is generally not recommended for use during pregnancy or breastfeeding unless it is clearly necessary, and only after your doctor has carefully weighed the potential benefits against the risks. Limited human data and animal studies suggest potential harmful effects on the developing baby. For breastfeeding mothers, it is probably unsafe as the medication may pass into breast milk and potentially harm the baby.

Can PALIRIS LA 100MG be taken with other medications?

Paliperidone, the active ingredient in PALIRIS LA 100MG, may interact with several other medications. These include other medicines for schizophrenia and bipolar disorder (e.g., aripiprazole, quetiapine), anxiety disorders (e.g., lorazepam, diazepam), depression (e.g., citalopram, sertraline), allergies (e.g., diphenhydramine), mania (e.g., divalproex sodium), seizures (e.g., gabapentin, lamotrigine), pain (e.g., oxycodone), and asthma (e.g., albuterol). It is crucial to inform your doctor about all medicines, including over-the-counter drugs and herbal supplements, you are currently taking to avoid potential interactions.

What precautions should be taken while using PALIRIS LA 100MG?

Several precautions should be observed while using PALIRIS LA 100MG:

• Alcohol Consumption: Avoid consuming alcohol, as it can increase drowsiness and dizziness.
• Driving and Machinery: Exercise caution when driving or operating heavy machinery, as this medicine can cause dizziness, sleepiness, and affect your ability to think clearly.
• Metabolic Monitoring: Regular monitoring of blood sugar, weight, cholesterol, and triglyceride levels is advised, as the medication may cause increases in these.
• Postural Hypotension: Rise slowly from a sitting or lying position to prevent dizziness or fainting due to a sudden drop in blood pressure.
• Kidney and Liver Conditions: Use with caution in patients with kidney disease or severe liver disease, as dose adjustments may be necessary. It is not recommended for use in patients with end-stage kidney disease.
• Allergies and NMS: Inform your doctor if you are sensitive to paliperidone, risperidone, or any other components of the injection. Immediately discontinue use and seek medical attention if Neuroleptic Malignant Syndrome (NMS) is suspected.
• Children: This medication is not recommended for use in children.
• Cardiac Conditions: Avoid use in patients with congenital long QT syndrome or a history of cardiac arrhythmias, as paliperidone can modestly increase the corrected QT (QTc) interval.

What happens if a dose of PALIRIS LA 100MG is missed?

If a monthly maintenance dose of PALIRIS LA 100MG is missed and less than 6 weeks have passed since your last injection, the previously stabilized dose should be administered as soon as possible. After that, resume your injections at monthly intervals. If more than 6 weeks have elapsed since the last injection, you should seek specialist advice. Do not take a double dose to compensate for a missed one.

How should PALIRIS LA 100MG be stored?

PALIRIS LA 100MG should be stored in a cool and dry place, away from direct sunlight. It should be kept out of the sight and reach of children. Some information specifies storage below 30°C or refrigerated at 2-8°C, protected from light, and not frozen. Always check the packaging for specific storage instructions.