Glychek M 40/500

GLYCHEK M 40/500 Tablet

GLYCHEK M 40/500 Tablet, manufactured by INDOCO REMEDIES LIMITED, is a combination medication primarily used for the management of Type 2 Diabetes Mellitus in adults.

Composition Each tablet contains:

• Gliclazide: 40 mg
• Metformin: 500 mg

Gliclazide belongs to the sulfonylurea class, working by stimulating insulin secretion from the pancreatic beta cells and reducing insulin resistance. Metformin, a biguanide, acts by decreasing glucose production in the liver and reducing intestinal absorption of glucose, while also increasing the body's response to insulin.

Uses GLYCHEK M 40/500 Tablet is prescribed to:

• Manage high blood sugar levels in adults with Type 2 Diabetes Mellitus.
• Complement a healthy diet and regular exercise regimen for effective diabetes control.
• Reduce the risk of serious diabetic complications such as kidney damage, blindness, nerve problems, and cardiovascular issues like heart attack or stroke.

Dosage and Administration The dosage is determined by a doctor based on individual patient factors.

• Typically, it is taken with food to minimize stomach upset.
• Swallow the tablet whole with a glass of water; do not crush, chew, or split it.
• Adhere strictly to the prescribed dose and schedule, usually once or twice daily, at the same time each day for optimal benefits.
• Do not stop the medication without consulting your doctor.

Side Effects Common side effects may include:

• Hypoglycaemia (low blood sugar), characterized by dizziness, sweating, palpitations, hunger pangs, and headache.
• Nausea or vomiting.
• Diarrhoea.
• Constipation.
• Abdominal pain.
• Metallic taste in the mouth.

A rare but serious side effect is lactic acidosis, indicated by deep or rapid breathing, persistent nausea, vomiting, and stomach pain. Seek immediate medical attention if these occur.

Precautions

• Pregnancy and Breastfeeding: Not recommended during pregnancy as it may harm the unborn baby, and caution is advised during breastfeeding as it's unknown if it passes into breast milk.
• Alcohol: Avoid alcohol consumption as it increases the risk of lactic acidosis and low blood sugar.
• Medical Conditions: Not recommended for individuals with Type 1 diabetes, diabetic ketoacidosis, severe liver or kidney disease, or chronic obstructive pulmonary disease. Caution is advised for patients with liver or kidney problems, heart disease, and G6PD deficiency.
• Drug Interactions: Inform your doctor about all other medications, supplements, and herbal products you are taking, as interactions can occur with other antidiabetic agents, antihypertensives, antifungals (e.g., fluconazole), and NSAIDs (e.g., ibuprofen).
• Monitoring: Regular monitoring of blood glucose and HbA1c levels, as well as kidney, liver, and thyroid function, is advised.
• Always carry a fast-acting source of glucose to manage potential hypoglycaemia.

Storage Store GLYCHEK M 40/500 Tablet below 30°C. Protect it from light and keep it out of reach of children. Ensure the medicine is used before its expiry date.

What is GLYCHEK M 40/500 used for?

GLYCHEK M 40/500 is primarily used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed alongside a healthy diet and regular exercise. This medication helps in controlling blood sugar, thereby reducing the risk of diabetes complications such as kidney damage, blindness, nerve problems, heart attack, or stroke.

How does GLYCHEK M 40/500 work?

GLYCHEK M 40/500 is a combination medicine containing two active ingredients: Gliclazide (40 mg) and Metformin (500 mg). Gliclazide, a sulfonylurea, works by stimulating the pancreatic beta cells to release more insulin and also helps reduce insulin resistance. Metformin, a biguanide, works by decreasing the production of glucose in the liver, reducing the absorption of glucose from the intestines, and improving the body's sensitivity to insulin. Together, these actions help to effectively lower blood glucose levels.

What is the usual dosage for GLYCHEK M 40/500?

The dosage of GLYCHEK M 40/500 should be strictly as advised by your doctor, as it can vary based on your condition and blood sugar levels. It is generally recommended to take the tablet with meals, usually once or twice daily. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or split.

What are the possible side effects of GLYCHEK M 40/500?

Common side effects can include low blood sugar (hypoglycemia), nausea, vomiting, diarrhea, stomach ache or gastric pain, constipation, metallic taste in the mouth, headache, dizziness, rash, itching (pruritus), and hives (urticaria). A rare but serious side effect is lactic acidosis, characterized by deep or rapid breathing, persistent nausea, vomiting, and stomach pain, which requires immediate medical attention. Long-term use may also lead to Vitamin B12 deficiency.

Is GLYCHEK M 40/500 safe during pregnancy or breastfeeding?

GLYCHEK M 40/500 is generally not recommended during pregnancy as there is evidence of risk to the developing baby, and caution is advised. For pregnancy-related diabetes, insulin is often the preferred treatment. During breastfeeding, the medicine is also not recommended as it may pass into breast milk and potentially harm the infant. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can GLYCHEK M 40/500 be taken with other medications?

GLYCHEK M 40/500 can interact with several other medications. Other antidiabetic agents (like insulins or acarbose), certain antihypertensives (e.g., propranolol, enalapril), some antifungals (e.g., fluconazole), and NSAIDs (e.g., ibuprofen) can increase its blood sugar-lowering effect. Conversely, certain medications like thiazide diuretics, corticosteroids, and thyroid hormones may reduce its effectiveness. Cationic medications such as amiloride, digoxin, and ranitidine may also interact by decreasing the elimination of metformin from the body. Always inform your doctor about all other medications you are taking to avoid potential interactions.

What precautions should be taken while taking GLYCHEK M 40/500?

It is important to monitor your blood sugar levels regularly while taking this medicine. Be aware of the symptoms of low blood sugar (hypoglycemia) such as sweating, dizziness, headache, and shaking, and always carry a fast-acting source of glucose like sugary food or fruit juice. Avoid alcohol consumption as it can increase the risk of both hypoglycemia and lactic acidosis. Inform your doctor about any pre-existing conditions, especially liver or kidney disease, heart problems, or if you are scheduled for surgery. Do not stop taking GLYCHEK M 40/500 without consulting your doctor, even if you feel well, as this can lead to a rise in blood sugar levels and an increased risk of complications. Your doctor may also recommend annual blood tests to monitor vitamin B12 levels and thyroid-stimulating hormone (TSH).

What happens if a dose of GLYCHEK M 40/500 is missed?

If you miss a dose of GLYCHEK M 40/500, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can cause a dangerous drop in blood glucose levels.

How should GLYCHEK M 40/500 be stored?

GLYCHEK M 40/500 tablets should be stored below 30°C (or 25°C), protected from light, and kept out of the reach of children. Ensure that you use the medicine before its expiry date, which is indicated on the package.