Crenzlo Injection

CRENZLO INJECTION

Name

• Brand Name: CRENZLO INJECTION
• Common Name: Inclisiran

Composition CRENZLO INJECTION contains Inclisiran, a 284mg/1.5ml solution. It is a PCSK9 inhibitor monoclonal antibody and is classified as a small interfering RNA (siRNA) therapy. It works by blocking PCSK9, a protein that regulates liver cell receptors responsible for clearing low-density lipoprotein cholesterol (LDL-C) from the bloodstream, thereby increasing LDL-C receptor numbers and lowering LDL-C levels.

Uses CRENZLO INJECTION is prescribed to lower LDL-C, often referred to as "bad cholesterol," in adults. It is used for medical conditions such as:

• Hyperlipidemia: Elevated levels of lipids in the blood.
• Heterozygous Familial Hypercholesterolemia (HeFH): A genetic condition causing high cholesterol.
• Clinical Atherosclerotic Cardiovascular Disease (ASCVD): To reduce the risk of cardiovascular events by preventing cholesterol buildup in arteries.

It is typically used as part of a comprehensive treatment plan that includes a balanced diet and other cholesterol-lowering medications, such as statins.

Dosage and Administration CRENZLO INJECTION is administered as a subcutaneous injection by a healthcare professional. The injection site is usually the abdomen, thigh, or upper arm. The typical schedule involves an initial dose, a second dose at three months, and subsequent doses every six months thereafter. Self-administration is not recommended unless properly trained. The prefilled syringe should not be shaken, as this can damage the medication.

Side Effects Common side effects may include:

• Injection site reactions (pain, redness, swelling)
• Headache, dizziness
• Cough, bronchitis
• Diarrhea
• Back pain, joint pain (arthralgia), pain in extremities
• Urinary tract infection
• Fever, chills

Most side effects are usually mild and may resolve over time. Persistent or worsening side effects should be reported to a doctor.

Precautions

• Inform your doctor about any allergies to the components of CRENZLO INJECTION.
• Consult a doctor if pregnant or breastfeeding, as its safety during these periods is not fully established.
• Not recommended for children under 18 years of age due to unestablished safety and efficacy.
• Patients with a history of heart, liver, or kidney disease, breathing problems, arthritis, psoriasis, eczema, or recent vaccinations should inform their doctor.
• Use with caution in patients with liver disease; dose adjustment may be needed. It is considered safe for use in kidney disease patients.
• Avoid injecting into red, bruised, or scarred areas of the skin.
• It should be continued alongside a healthy diet and statin therapy.

Storage CRENZLO INJECTION should be stored in a cool and dry place, protected from sunlight, at temperatures between 10°C to 25°C or below 30°C. It should be kept in its original packaging until use and out of the sight and reach of children.

Here are some frequently asked questions about Crenzlo Injection:

What is Crenzlo Injection used for?

Crenzlo Injection is used to lower high levels of low-density lipoprotein (LDL) cholesterol, often referred to as "bad" cholesterol. It is prescribed for adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who require further LDL-C reduction, typically as part of a comprehensive treatment plan including a balanced diet and other medications like statins.

How does Crenzlo Injection work?

Crenzlo Injection contains Inclisiran, which is a PCSK9 inhibitor. It works by blocking a protein called PCSK9. By inhibiting PCSK9, it increases the number of LDL receptors on liver cells, allowing the liver to remove more LDL cholesterol from the bloodstream. This effectively lowers LDL-C levels and reduces the risk of atherosclerotic cardiovascular diseases.

What is the usual dosage of Crenzlo Injection?

Crenzlo Injection is administered by a healthcare professional. The usual dosing schedule involves an initial dose, followed by a second dose after 3 months, and then subsequent doses every 6 months thereafter.

What are the possible side effects of Crenzlo Injection?

Common side effects can include headache, dizziness, cough, bronchitis, diarrhea, back pain, joint pain (arthralgia), and reactions at the injection site such as pain, redness, or swelling. Most injection site reactions are mild and resolve on their own.

Is Crenzlo Injection safe during pregnancy or breastfeeding?

Crenzlo Injection is generally not recommended during pregnancy or breastfeeding. The safety of Inclisiran during these periods has not been established. Limited human data suggest the drug may pass into breast milk and potentially harm the baby. It is crucial to consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can Crenzlo Injection be taken with other medications?

Crenzlo Injection has shown minimal interactions with most other cholesterol-lowering medications and is suitable for use in combination with other treatments, such as statins. No significant drug-drug, drug-food, or drug-disease interactions have been specifically noted for Inclisiran. However, always inform your doctor about all medications, supplements, and herbal remedies you are taking.

What precautions should be taken with Crenzlo Injection?

Before receiving Crenzlo Injection, inform your doctor about any allergies you have, or if you have a history of heart, kidney, or liver disease, breathing problems, arthritis, psoriasis, eczema, urinary tract infections, or any recent vaccinations. Crenzlo Injection is not recommended for individuals under 18 years of age.

What happens if a dose of Crenzlo Injection is missed?

If a dose is missed by less than 3 months, your doctor will administer the injection as soon as possible and continue with the original dosing schedule. If more than 3 months have passed since the missed dose, a new treatment schedule will typically be restarted with an initial dose, followed by another dose at 3 months, and then every 6 months thereafter.

How should Crenzlo Injection be stored?

Crenzlo Injection should be stored in a cool and dry place, away from direct sunlight. The recommended storage temperature is typically between 10°C to 25°C or below 30°C. It should be kept in its original packaging until ready for use and out of the sight and reach of children.