Tozam (50+5mg) Tab

TOZAM (50+5MG) TABLET

TOZAM (50+5MG) Tablet, manufactured by Torrent Pharmaceuticals Ltd., is a combination medication prescribed for the management of high blood pressure.

• Name

  • Brand Name: TOZAM (50+5MG) TAB
  • Common Names: Losartan Potassium and Amlodipine Besilate Tablet

• Composition Each film-coated tablet contains:

  • Losartan Potassium: 50 mg (an angiotensin II receptor blocker or ARB)
  • Amlodipine Besilate: 5 mg (a calcium channel blocker or CCB) These active ingredients work together to relax and widen blood vessels, improve blood flow, and reduce strain on the heart, leading to a reduction in blood pressure.

• Uses TOZAM is primarily used for the treatment of:

  • Mild to moderate hypertension (high blood pressure) It also helps to reduce the risk of serious cardiovascular events such as stroke, heart attack, and kidney problems associated with hypertension.

• Dosage and Administration

  • Typically, one tablet is taken once daily, or as directed by a physician.
  • It can be taken with or after a meal to minimize potential side effects.
  • Swallow the tablet whole with water; do not crush or chew it.
  • For optimal results, it is important to take the medicine at the same time each day.
  • If a dose is missed, take it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.

• Side Effects

  • Common Side Effects: Nausea, headache, dizziness, fatigue, flushing (sense of warmth), edema (swelling, particularly ankle swelling), abdominal pain, heartburn, body pain, diarrhea, back pain, muscle cramps, nasal congestion, taste changes, sleepiness, palpitations, and increased potassium levels in the blood (hyperkalaemia).
  • Serious Side Effects (seek immediate medical attention if experienced): Problems with heart rhythms, slow heart rate, muscle weakness (indicating high potassium levels), allergic reactions such as swelling of the tongue, throat, lips, or face, and signs of kidney problems like swelling in the ankles, feet, or hands, or sudden weight gain. Worsening of angina or acute myocardial infarction, symptomatic hypotension, and renal deterioration can also occur.

• Precautions

  • Contraindications: Do not use if allergic to Losartan, Amlodipine, or any other ingredients. It is contraindicated during pregnancy and breastfeeding. Concomitant use with aliskiren is contraindicated in patients with diabetes. Avoid if you have very low blood pressure, abnormal narrowing of the aorta heart valve, or heart failure.
  • Warnings: Avoid consuming alcohol, as it may increase the risk of dizziness and fainting. Use with caution in patients with kidney or liver problems; dose adjustments may be necessary. Avoid potassium supplements or medications that can increase potassium levels in the body, such as potassium-sparing diuretics. Inform your doctor about all other medications, supplements, or herbal products you are taking, especially other blood pressure drugs, lithium, NSAIDs (like ibuprofen), or aliskiren. This medicine may cause dizziness or drowsiness, so avoid driving or operating heavy machinery until you know how it affects you. Special caution is advised for elderly patients and those with volume depletion or salt restriction. Not recommended for children below six years.

• Storage

  • Store TOZAM tablets in a cool, dry place.
  • Protect from direct sunlight, moisture, and heat.
  • Keep out of the sight and reach of children and pets.
  • Store below 30°C in a tightly closed, light-resistant container.

TOZAM (50+5MG) Tablets by Torrent Pharmaceuticals Ltd. are a combination medication primarily used for the management of high blood pressure. Each tablet contains Losartan 50 mg and Amlodipine 5 mg.

Here are some frequently asked questions about TOZAM (50+5MG) TAB:

What is TOZAM used for?

TOZAM is used to treat mild to moderate high blood pressure (hypertension). It helps lower blood pressure and is also indicated to reduce the risk of cardiovascular events such as heart attack and stroke.

How does TOZAM work?

TOZAM contains two active ingredients: Losartan and Amlodipine. Losartan is an angiotensin II receptor blocker (ARB) that works by blocking a hormone that tightens blood vessels and causes the body to retain salt and water, allowing blood vessels to relax. Amlodipine is a calcium channel blocker (CCB) that relaxes and widens blood vessels by blocking calcium entry into their muscle walls. Together, these actions lower blood pressure and reduce the workload on the heart.

What is the usual dosage for TOZAM?

The usual dosage is one tablet once a day, or as directed by your doctor. It can be taken with or after a meal, swallowed whole with water, and it is important to take it at the same time each day for optimal results.

What are the possible side effects of TOZAM?

Common side effects may include headache, dizziness, fatigue, nausea, abdominal pain, swelling (edema, particularly ankle swelling), flushing, heartburn, body pain, and diarrhea. Some people might also experience muscle cramps, back pain, or increased potassium levels in the blood (hyperkalemia). If you experience severe reactions such as very low blood pressure, a fast heartbeat, or trouble breathing, seek immediate medical help.

Is TOZAM safe during pregnancy or breastfeeding?

TOZAM should generally not be administered during pregnancy or breastfeeding. It is contraindicated in pregnant women as it can cause fetal harm, and safety for nursing infants has not been established. Women of childbearing potential should ensure effective contraception while taking this medicine.

Can TOZAM be taken with other medications?

Caution is advised when taking TOZAM with other medications. It can interact with other blood pressure-lowering medicines, certain water pills (diuretics, especially potassium-sparing ones), potassium supplements, and nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, which can further lower blood pressure or affect kidney function and potassium levels. Medicines containing lithium can have increased levels in the body if taken with TOZAM. It is important to inform your doctor about all medicines you are taking.

What precautions should be taken while on TOZAM?

Avoid consuming alcohol while taking TOZAM as it can lead to an excessive drop in blood pressure and cause dizziness. Since this medicine can cause dizziness, especially at the start of treatment or when the dose is increased, avoid driving or operating heavy machinery until you know how it affects you. Use with caution in patients with liver disease, and dosage adjustments may be required.

What happens if a dose of TOZAM is missed?

If you miss a dose of TOZAM, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up, as this can lead to an excessive drop in blood pressure and other adverse effects.

How should TOZAM be stored?

TOZAM tablets should be stored in a cool, dry place, protected from direct sunlight, moisture, and heat. Keep it out of the reach of children and pets.