JANUMET 50mg/500mg Tablet

Name

• Generic Name: Sitagliptin and Metformin Hydrochloride
• Brand Name: JANUMET

Composition

• Each tablet contains:
  • Sitagliptin phosphate equivalent to Sitagliptin 50 mg
  • Metformin hydrochloride 500 mg

Uses

• Indicated for:
  • The management of type 2 diabetes mellitus in adults, especially as an adjunct to diet and exercise.
  • For patients inadequately controlled on metformin or sitagliptin alone, or those already being treated with both agents separately.

Dosage and Administration

• Typical Dosage:
  • The usual starting dose is one tablet (50 mg/500 mg) taken twice daily with meals.
  • Dosage may be adjusted based on therapeutic response and tolerability.
  • Tablets should be swallowed whole and not split, crushed, or chewed.
• Maximum recommended daily dose:
  • Sitagliptin: 100 mg
  • Metformin: 2000 mg

Side Effects

• Common:
  • Nausea, diarrhea, abdominal discomfort, headache, upper respiratory tract infection.
• Serious:
  • Lactic acidosis (rare but potentially fatal), pancreatitis, hypoglycemia (especially when used with insulin or sulfonylureas), allergic reactions (rash, urticaria, angioedema).

Precautions

• Warnings:
  • Not for use in patients with type 1 diabetes or for diabetic ketoacidosis.
  • Use with caution in patients with renal impairment; dose adjustment may be necessary.
  • Risk of lactic acidosis increases with conditions such as renal dysfunction, advanced age, dehydration, or use of contrast agents.
  • Monitor renal function before and during treatment.
• Drug Interactions:
  • May interact with other glucose-lowering agents, diuretics, corticosteroids, and medications affecting renal function.

Storage

• Store below 30°C.
• Protect from moisture and keep in the original packaging.
• Keep out of reach of children.

FAQs about JANUMET 50mg/500mg Tablet

What is JANUMET used for?

JANUMET is a prescription medicine used to improve blood sugar control in adults with type 2 diabetes mellitus. It is used along with diet and exercise and may be used alone or with other diabetes medications.

How does JANUMET work?

JANUMET contains two active ingredients: sitagliptin and metformin. Sitagliptin increases the levels of hormones that help regulate blood sugar, while metformin decreases glucose production in the liver and improves the body’s sensitivity to insulin.

What is the usual dosage for JANUMET?

The typical starting dose is one tablet (50mg sitagliptin/500mg metformin) taken twice daily with meals. The dosage may be adjusted by your doctor based on your blood sugar response and kidney function.

What are the possible side effects of JANUMET?

Common side effects include nausea, diarrhea, stomach upset, headache, and upper respiratory tract infections. Rare but serious side effects can include lactic acidosis, pancreatitis, and severe allergic reactions.

Is JANUMET safe during pregnancy or breastfeeding?

JANUMET is generally not recommended during pregnancy or breastfeeding. If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking this medication.

Can JANUMET be taken with other medications?

JANUMET can interact with certain medications, including diuretics, corticosteroids, and some heart and blood pressure medicines. Inform your doctor about all the medicines and supplements you are taking.

What precautions should be taken while using JANUMET?

Tell your doctor if you have kidney or liver problems, a history of pancreatitis, or heart problems. Avoid excessive alcohol intake as it can increase the risk of lactic acidosis. Regular blood sugar monitoring is important.

What should I do if I miss a dose of JANUMET?

If you miss a dose, take it as soon as you remember with food. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time.

How should JANUMET be stored?

Store JANUMET at room temperature, away from moisture and heat. Keep it out of reach of children and do not use it past the expiration date.