NEXOVAS BETA TABLET by MACLEODS PHARMACEUTICALS LTD.

Nexovas Beta Tablet is a prescription medication primarily used for the management of hypertension (high blood pressure). It is a combination therapy designed for individuals whose blood pressure is not adequately controlled by a single medication, or who require multiple medicines to achieve satisfactory results. By effectively lowering blood pressure, it helps reduce the risk of future cardiovascular events such as heart attack and stroke.

Composition

Nexovas Beta Tablet contains two active ingredients:

• Cilnidipine (10 mg): A calcium channel blocker that relaxes and widens blood vessels, allowing blood to flow more easily. It also reduces the release of norepinephrine, a substance that constricts blood vessels.
• Nebivolol (5 mg): A selective β1-adrenergic receptor blocker (beta-blocker) that works by slowing the heart rate and relaxing blood vessels. This reduces the workload on the heart and helps lower blood pressure.

Uses

Nexovas Beta Tablet is prescribed for:

• Treatment of essential hypertension (high blood pressure).
• Controlling blood pressure when a single medication is not effective.
• Reducing the risk of stroke and heart attack associated with high blood pressure.

Dosage and Administration

Take Nexovas Beta Tablet in the dose and duration as advised by your doctor.

• Swallow the tablet whole with a glass of water; do not chew, crush, or break it.
• It can be taken with or without food, but it is generally recommended to take it at the same time each day for optimal results.
• Do not stop taking the medication suddenly without consulting your doctor, as it can cause a sudden increase in blood pressure.

Side Effects

Common side effects may include:

• Headache
• Dizziness
• Ankle swelling (edema/peripheral oedema)
• Flushing (sense of warmth in the face, ears, neck, and trunk)
• Slow heart rate (bradycardia)
• Tiredness/Fatigue
• Nausea
• Constipation
• Low blood pressure (hypotension)
• Breathlessness
• Paresthesia (tingling or pricking sensation)

Serious side effects are rare but may include worsening heart failure, very slow heartbeat, fainting, chest pain, or signs of liver problems. Consult your doctor if any side effects persist or worsen.

Precautions

• Pregnancy and Breastfeeding: Not generally recommended during pregnancy or breastfeeding unless considered clearly necessary and advised by a doctor.
• Liver/Kidney Problems: Use with caution in patients with liver or severe kidney disease; dose adjustment may be necessary. It is contraindicated in severe liver disease.
• Heart Conditions: Contraindicated in individuals with very low blood pressure, severe heart block without a pacemaker, slow heartbeat, or uncontrolled heart failure. Use with caution in patients with heart failure, poor heart function, or slow heart rate.
• Diabetes: May mask the symptoms of low blood sugar.
• Alcohol: Caution is advised as alcohol may enhance the blood pressure-lowering effect.
• Driving: May cause dizziness or sleepiness; avoid driving or operating machinery until you know how the medicine affects you.
• Interactions: Inform your doctor about all other medications you are taking, especially heart rhythm drugs, other blood pressure medications, diabetes medications, mental health medications, and certain antibiotics or stomach medications, as interactions can occur.
• Regular monitoring of blood pressure, kidney function, blood sugar levels, and electrolytes may be required during treatment.

Storage

Store Nexovas Beta Tablet in a cool, dry place, ideally between 15-30°C. Protect it from excessive light and moisture. Keep it out of reach of children.

What is Nexovas Beta Tablet used for?

Nexovas Beta Tablet is a prescription medicine primarily used to treat hypertension (high blood pressure). It is often prescribed when a single medication is not sufficient to control blood pressure. By effectively lowering high blood pressure, it helps to reduce the chances of future heart attacks, strokes, and kidney problems.

How does Nexovas Beta Tablet work?

This medicine contains two active ingredients: Cilnidipine and Nebivolol. Cilnidipine is a calcium channel blocker that works by relaxing and widening blood vessels, allowing blood to flow more easily throughout the body. Nebivolol is a beta-blocker that slows down the heart rate and also relaxes blood vessels, thereby reducing the workload on the heart and lowering blood pressure.

What is the usual dosage of Nexovas Beta Tablet?

Nexovas Beta Tablet should be taken exactly as advised by your doctor. It is typically taken once daily. You should swallow the tablet whole with a glass of water, with or without food. For optimal results, it is best to take it at the same time each day. Do not chew, crush, or break the tablet, and do not exceed the prescribed dose.

What are the possible side effects of Nexovas Beta Tablet?

Common side effects may include headache, dizziness, tiredness or fatigue, ankle swelling (edema), slow heart rate (bradycardia), low blood pressure (hypotension), nausea, constipation, diarrhea, and flushing (a sense of warmth in the face, ears, neck, and trunk). If any of these side effects persist or worsen, consult your doctor. Serious side effects, though rare, can include worsening heart failure, very slow heartbeat, fainting, chest pain, difficulty breathing, or signs of liver problems (e.g., yellowing of the skin or eyes), which require immediate medical attention.

Is Nexovas Beta Tablet safe during pregnancy or breastfeeding?

Nexovas Beta Tablet is generally not recommended for use during pregnancy unless your doctor considers it clearly necessary and advises it, in which case uteroplacental blood flow and fetal growth should be monitored. It is also not recommended for use by breastfeeding women. Always consult your doctor before taking this medicine if you are pregnant or breastfeeding.

Can Nexovas Beta Tablet be taken with other medications?

Nexovas Beta Tablet can interact with other medications. It is crucial to inform your doctor about all the medicines you are currently taking, including over-the-counter drugs, vitamins, and herbal supplements. Special caution is advised when taken with other blood pressure-lowering medications (which can lead to excessively low blood pressure), certain heart rhythm drugs (which may slow your heart rate too much), Nonsteroidal Anti-inflammatory Drugs (NSAIDs) like ibuprofen (which can decrease its blood pressure-lowering effects), and medications that affect liver enzymes.

What precautions should be taken while using Nexovas Beta Tablet?

Do not stop taking Nexovas Beta Tablet suddenly without consulting your doctor, as this can lead to a sudden and dangerous increase in blood pressure. This medicine may cause dizziness or sleepiness, so avoid driving or operating heavy machinery until you understand how it affects you. Inform your doctor if you have any pre-existing conditions such as liver or kidney problems, heart conditions (e.g., slow heart rate, heart block, heart failure), asthma or other lung diseases, diabetes (as it may mask symptoms of low blood sugar), or thyroid problems. Alcohol consumption should be done with caution, as it may enhance the blood pressure-lowering effect of the medicine. Always inform your doctor if you are scheduled for any surgery or anesthesia.

What happens if a dose of Nexovas Beta Tablet is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should Nexovas Beta Tablet be stored?

Nexovas Beta Tablet should be stored at room temperature, ideally between 15°C and 30°C (or below 30°C). Keep the medicine protected from excessive light, moisture, and heat. Always ensure it is kept out of the sight and reach of children.