Oratil Cv 250

ORATIL CV 250

ORATIL CV 250 is a broad-spectrum antibiotic manufactured by Macleods Pharmaceuticals Pvt Ltd, used to treat a wide range of bacterial infections.

• Name: Oratil CV 250 Tablet
• Composition: Each tablet contains Cefuroxime (250 mg) and Clavulanic Acid (125 mg). Cefuroxime is a cephalosporin antibiotic that prevents the formation of bacterial cell walls, leading to bacterial death. Clavulanic Acid is a beta-lactamase inhibitor that reduces bacterial resistance and enhances the activity of cefuroxime against bacteria.
• Uses: ORATIL CV 250 is prescribed for various bacterial infections, including:
  • Pharyngitis and tonsillitis (throat infections).
  • Acute bacterial otitis media (middle ear infection).
  • Acute bacterial maxillary sinusitis.
  • Lower respiratory tract infections, such as pneumonia and bronchitis.
  • Uncomplicated skin and skin structure infections.
  • Uncomplicated urinary tract infections (UTIs).
  • Uncomplicated gonorrhea and early Lyme disease.
  • Bone and joint infections, septicemia, and meningitis.
• Dosage and Administration: ORATIL CV 250 should be taken as directed by a physician. It can be taken with or after food to lessen stomach discomfort. Swallow the tablet whole; do not crush or chew. The dosage and duration depend on the severity of the condition and patient response, and it is crucial to complete the entire prescribed course even if symptoms improve.
• Side Effects: Common side effects may include:
  • Diarrhea
  • Nausea
  • Vomiting
  • Abdominal pain or discomfort
  • Headache
  • Vaginal yeast infection
  • Increased liver enzymes
  • Allergic reactions (rash, itching, swelling, shortness of breath). Consult a doctor if any side effects worsen or persist.
• Precautions:
  • Allergies: Do not take if allergic to cefuroxime, clavulanate, other cephalosporin antibiotics, penicillin, or any other ingredients.
  • Medical Conditions: Use with caution in patients with a history of gastrointestinal disease (especially colitis), kidney problems, or liver problems.
  • Pregnancy and Breastfeeding: Caution is advised during pregnancy, and it is generally not recommended for breastfeeding women as traces may pass into breast milk. Consult a doctor.
  • Drug Interactions:
    • Uricosurics (e.g., Probenecid) can increase cefuroxime levels.
    • Anticoagulants (e.g., Warfarin) may have their effects enhanced, increasing bleeding risk.
    • Stomach acid reducers (e.g., Cimetidine, Famotidine) can decrease cefuroxime effectiveness.
    • May interfere with the effectiveness of oral contraceptives.
    • May interact with live vaccines; maintain a time gap.
  • Alcohol: Avoid alcohol consumption as it can cause excessive drowsiness.
  • Pediatric Use: Not recommended for children under three months of age.
• Storage: Store in a cool and dry place, away from direct sunlight. Keep the medicine in its original container, tightly closed, and out of reach of children and pets. Store below 30°C.

What is ORATIL CV 250 used for?

ORATIL CV 250 is an antibiotic primarily used to treat a wide range of bacterial infections. These infections can include those affecting the throat (pharyngitis/tonsillitis), ears (otitis media), sinuses (sinusitis), lower respiratory tract (such as pneumonia and bronchitis), skin and soft tissues, urinary tract, bones, and joints. It is also effective against sexually transmitted diseases like gonorrhoea and early Lyme disease, as well as more serious conditions like septicaemia (bloodstream infection) and meningitis (inflammation of the brain and spinal cord). It is not effective against viral infections.

How does ORATIL CV 250 work?

ORATIL CV 250 is a combination medicine containing two active ingredients: Cefuroxime (a cephalosporin antibiotic) and Clavulanic acid (a beta-lactamase inhibitor). Cefuroxime works by preventing the formation of the bacterial cell wall, which is vital for the bacteria's survival, thereby killing them. Clavulanic acid's role is to decrease bacterial resistance by inhibiting beta-lactamase enzymes produced by some bacteria. These enzymes can inactivate antibiotics like cefuroxime, so clavulanic acid enhances cefuroxime's activity against these resistant bacteria.

What is the usual dosage of ORATIL CV 250?

The dosage of ORATIL CV 250 is determined by your doctor, considering factors such as your body weight, medical history, gender, age, the severity of your condition, and your response to the medicine. It is crucial to take the medicine exactly as prescribed by your doctor. For instance, for sinusitis, a typical dosage might be one 250mg tablet twice daily for 10 days, though this can vary. The tablet should be swallowed whole with a glass of water, either with or after food, and should not be crushed, broken, or chewed. It is advisable to take it at a consistent time each day for optimal results.

What are the possible side effects of ORATIL CV 250?

Some common side effects of ORATIL CV 250 include diarrhoea, nausea, vomiting, abdominal pain or discomfort, headache, and vaginal yeast infection. Other less common side effects can include stomach pain, flatulence, indigestion, sleepiness, mouth ulcers, thirst, lack of appetite, increased liver enzymes, low blood count, shortness of breath, itching, redness, chills, and chest pain. Most of these side effects are temporary and usually resolve over time. However, if any side effects persist, worsen, or become severe (e.g., diarrhoea with blood and mucus, stomach pain, and fever), it is important to consult your doctor.

Is ORATIL CV 250 safe during pregnancy or breastfeeding?

Pregnancy: Caution is advised when taking ORATIL CV 250 during pregnancy. While some sources indicate it belongs to pregnancy category B and can be used if deemed essential by a doctor after weighing benefits against risks, limited human studies exist. Animal studies have shown low or no adverse effects on the developing baby. Always consult your doctor if you are pregnant or planning to become pregnant.

Breastfeeding: It is generally recommended to avoid taking ORATIL CV 250 while breastfeeding, as its components may pass into breast milk. Although some sources state it enters breast milk at low levels and is considered safe if prescribed, and that human data states it does not pass into breast milk and is not harmful to the baby, it is still crucial to consult your doctor. If used during breastfeeding, the baby should be monitored for symptoms such as diarrhoea and yeast infection.

Can it be taken with other medications?

ORATIL CV 250 can interact with certain other medications. It is important to inform your doctor about all medicines you are currently taking, including over-the-counter drugs and herbal preparations.

• Uricosurics (e.g., Probenecid): Probenecid can increase the level of cefuroxime in your body, potentially increasing the risk of side effects.
• Anticoagulants (e.g., Warfarin): Cefuroxime may enhance the effect of anticoagulants, possibly leading to an increased risk of bleeding.
• Stomach acid reducers (e.g., Cimetidine, Famotidine, Antacids like sodium bicarbonate and aluminium hydroxide): These medications can reduce stomach acidity, which might decrease the absorption and effectiveness of cefuroxime.
• Oral Contraceptives: Oral contraceptives should be used cautiously.
• Potent diuretics (e.g., chlorothiazide, indapamide): ORATIL CV 250 should be used with caution in patients receiving concurrent treatment with potent diuretics.
• Live Vaccines (e.g., Cholera Vaccine, BCG vaccine): ORATIL CV 250 may interact with live vaccines, so a time gap of at least 2 hours between administration is advised.

What precautions should be taken?

Before taking ORATIL CV 250, inform your doctor if you have any allergies (especially to penicillin or other cephalosporin antibiotics), kidney problems, liver problems, or gastrointestinal diseases like colitis. Do not self-medicate, as this can lead to antibiotic resistance, making antibiotics ineffective against bacterial infections. Avoid alcohol consumption as it may cause unpleasant side effects such as increased dizziness or drowsiness. While ORATIL CV 250 generally does not impair driving ability, you should avoid driving or operating machinery if you feel dizzy or drowsy. Complete the entire prescribed course of treatment even if your symptoms improve, to ensure the infection is fully cured and to prevent recurrence and antibiotic resistance.

What happens if a dose is missed?

If you miss a dose of ORATIL CV 250, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Completing the full course of treatment is crucial for the effectiveness of the medicine.

How should it be stored?

ORATIL CV 250 should be stored in a cool and dry place, away from direct sunlight and moisture. Keep it in its original packet or a tightly closed container. Ensure it is kept out of sight and reach of children and pets. The recommended storage temperature is typically between 10ºC to 25ºC or below 30ºC.