Glucreta M 5/1000mg Tab

GLUCRETA M 5/1000MG Tablet

GLUCRETA M 5/1000MG Tablet is a combination medication primarily used for the management of type 2 diabetes mellitus in adults. Manufactured by Torrent Pharmaceuticals Ltd., it helps control high blood sugar levels when diet and exercise alone are insufficient.

Composition

GLUCRETA M 5/1000MG Tablet contains two active ingredients:

• Dapagliflozin (5 mg): An SGLT2 inhibitor that works by causing the kidneys to remove excess glucose from the body through urine, thereby lowering blood sugar levels.
• Metformin Hydrochloride (1000 mg): A biguanide that reduces glucose production in the liver, decreases glucose absorption from the intestines, and increases the body's sensitivity to insulin.

Uses

GLUCRETA M 5/1000MG Tablet is prescribed for:

• Managing type 2 diabetes mellitus in adults, especially when diet and exercise do not adequately control blood sugar levels.
• Reducing the risk of hospitalization due to heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.
• Improving blood sugar control in combination with insulin or GLP-1 receptor agonists like liraglutide.

Dosage and Administration

This medication is typically taken orally, once daily, with food to minimize gastrointestinal side effects. The tablets should be swallowed whole and not crushed, chewed, or broken. The dosage and duration of treatment are determined by a physician based on the patient's condition, age, body weight, and treatment response. Regular monitoring of blood sugar levels is essential.

Side Effects

Common side effects may include:

• Diarrhea, nausea, vomiting, stomach pain, loss of appetite.
• Urinary tract infections (UTIs) and genital fungal infections.
• Increased urination.
• Headache, nasal congestion, runny nose, sore throat.
• Dehydration.
• Low blood sugar (hypoglycemia), especially when used with other antidiabetic medicines or if meals are skipped.

Serious side effects, though rare, can include lactic acidosis (symptoms like nausea, vomiting, stomach pain, muscle cramps, severe tiredness, difficulty breathing, dizziness) and kidney function impairment.

Precautions

• Kidney and Liver Conditions: Not recommended for patients with moderate to severe kidney disease or liver disease. It should be used with caution in patients with existing kidney or liver problems, and kidney function should be assessed before and periodically during treatment.
• Alcohol Consumption: Avoid excessive alcohol intake as it may increase the risk of lactic acidosis and can affect blood sugar control.
• Pregnancy and Breastfeeding: Not recommended during the second and third trimesters of pregnancy unless clearly necessary, and generally not advised for breastfeeding women as it may pass into breast milk.
• Dehydration: Drink plenty of fluids to prevent dehydration, as the medication can cause increased urination and fluid loss.
• Other Conditions: Not recommended for patients with type 1 diabetes mellitus, diabetic ketoacidosis, recent heart attack, heart failure, septicemia, or severe infection. Caution is advised in elderly patients.
• Drug Interactions: May interact with diuretics, insulin, insulin secretagogues, and carbonic anhydrase inhibitors, potentially increasing the risk of hypoglycemia or lactic acidosis. Beta-blockers may mask symptoms of hypoglycemia.

Storage

Store in a cool, dry place away from the reach of children, below 30°C. Protect from moisture and light. Do not use medicines past their expiry date.

GLUCRETA M 5/1000MG TAB is a medication prescribed for individuals with type 2 diabetes mellitus. It combines two active ingredients, Dapagliflozin and Metformin, to help manage blood sugar levels and reduce the risk of certain complications associated with diabetes.

What is GLUCRETA M 5/1000MG TAB used for?

GLUCRETA M 5/1000MG TAB is used to manage type 2 diabetes mellitus in adults, particularly when diet and exercise alone do not provide adequate blood sugar control. It also helps reduce the risk of serious complications, including heart disease and hospitalization due to heart failure, in adults with type 2 diabetes and cardiovascular disease or multiple cardiovascular risk factors.

How does GLUCRETA M 5/1000MG TAB work?

This medication contains two active ingredients: Dapagliflozin and Metformin. Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that works by causing the kidneys to remove excess sugar from the body through urine, thus lowering blood glucose levels. Metformin, a biguanide, reduces glucose production in the liver, decreases the absorption of glucose from the intestines, and increases the body's sensitivity to insulin. Together, they provide better control of blood sugar.

What is the usual dosage of GLUCRETA M 5/1000MG TAB?

GLUCRETA M 5/1000MG TAB is typically taken once daily with food, swallowed whole without crushing or chewing. Your doctor will determine the exact dose and duration of treatment based on your individual condition and response to the medication.

What are the possible side effects of GLUCRETA M 5/1000MG TAB?

Common side effects can include a sore throat, nasal congestion, runny nose, headache, nausea, vomiting, diarrhea, stomach pain, and loss of appetite. Other potential side effects include genital fungal infections, urinary tract infections, increased urination, and dehydration. More serious, though less common, side effects can include low blood sugar (hypoglycemia, especially when used with other diabetes medications), lactic acidosis (a rare but serious complication of Metformin), and kidney problems.

Is GLUCRETA M 5/1000MG TAB safe during pregnancy or breastfeeding?

GLUCRETA M 5/1000MG TAB is generally not recommended during the second and third trimesters of pregnancy unless considered clearly necessary, and it's also not recommended during breastfeeding as it may pass into breast milk. Pregnant or breastfeeding women, or those planning to become pregnant, should consult their healthcare provider before using this medication.

Can GLUCRETA M 5/1000MG TAB be taken with other medications?

It's important to inform your doctor about all other medications, supplements, or herbal products you are taking to avoid potential interactions. Caution is advised when taking it with diuretics (water pills), as this can increase the risk of dehydration and low blood pressure. Using it with insulin or other insulin secretagogues (like sulfonylureas) may increase the risk of low blood sugar. Certain carbonic anhydrase inhibitors can also increase the risk of lactic acidosis when taken with this medicine.

What precautions should be taken while using GLUCRETA M 5/1000MG TAB?

Regular monitoring of blood sugar levels and kidney function is crucial. It's important to stay well-hydrated to prevent dehydration, as the medication can cause increased urination. Maintaining good hygiene can help prevent genital fungal infections. Avoid excessive alcohol consumption, as it may increase the risk of certain side effects, including lactic acidosis. Inform your doctor if you have existing kidney or liver issues, urinary tract infections, or a history of heart problems.

What happens if a dose of GLUCRETA M 5/1000MG TAB is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should GLUCRETA M 5/1000MG TAB be stored?

GLUCRETA M 5/1000MG TAB should be stored in a cool, dry place and kept out of reach of children. Always check the expiry date and do not use the medicine past this date.