Stalix M Xr 100+500 Tablet (10 Tab)

STALIX M XR 100+500 TABLET is a combination medication used for the management of type 2 diabetes mellitus. It is manufactured by Torrent Pharmaceuticals Ltd..

Name

• Brand Name: STALIX M XR 100+500 TABLET
• Common Name: Sitagliptin and Metformin Hydrochloride Extended Release Tablet

Composition

STALIX M XR 100+500 TABLET contains two active ingredients:

• Sitagliptin (100 mg): A dipeptidyl peptidase-4 (DPP-4) inhibitor that works by increasing the levels of incretin hormones, which, in turn, increase insulin release after meals and decrease the amount of sugar produced by the liver. It also reduces glucagon secretion.
• Metformin Hydrochloride (500 mg): A biguanide that primarily reduces glucose production in the liver, delays glucose absorption from the intestines, and improves the body's sensitivity to insulin. The extended-release (XR) formulation ensures a slow and steady release of the medication.

Uses

This medicine is prescribed for:

• Treatment of type 2 diabetes mellitus in adults.
• Lowering high blood sugar levels and improving glycemic control when diet and exercise alone are insufficient.
• Improving insulin sensitivity.
• Reducing the risk of serious complications of diabetes, such as kidney damage, eye damage, nerve problems, and cardiovascular issues.

Dosage and Administration

• The usual dosage is one tablet taken orally once or twice daily with meals to minimize gastrointestinal discomfort.
• It should be swallowed whole with a glass of water and not crushed, chewed, or broken.
• Consistency is important; take it at the same time each day for optimal results.
• The exact dosage and duration will be determined by a healthcare provider based on blood sugar levels and other medical conditions.

Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea, stomach pain, and loss of appetite.
• Hypoglycemia (low blood sugar), especially when used with other diabetes medications like insulin or sulfonylurea. Symptoms include shakiness, sweating, anxiety, blurred vision, dizziness, hunger pangs, and confusion.
• Headache.
• Upper respiratory tract infection, stuffy nose, sore throat, or nasopharyngitis.
• Metallic taste in the mouth.
• Joint pain.

Serious but rare side effects can include:

• Lactic acidosis, a medical emergency characterized by increased levels of lactic acid in the blood. Symptoms may include deep or rapid breathing, persistent nausea, vomiting, stomach pain, muscle pain or weakness, dizziness, tiredness, a feeling of cold in arms and legs, and a slow heart rate.
• Vitamin B12 deficiency with long-term use.
• Liver problems.
• Severe skin reactions (bullous pemphigoid).

Precautions

• Contraindications: Not recommended for patients with severe kidney disease, liver disease, type 1 diabetes mellitus, diabetic ketoacidosis, severe uncontrollable diabetes, alcoholism, shock, or severe heart problems (such as acute heart failure or a recent heart attack).
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding; consult a doctor.
• Alcohol Consumption: Avoid or limit alcohol consumption as it can increase the risk of lactic acidosis and lower blood glucose.
• Other Medications: Inform your doctor about all other medications, supplements, or herbal remedies you are taking, as interactions may occur.
• Monitoring: Regular monitoring of blood sugar levels and kidney function is crucial during treatment.
• Pancreatitis: Inform your doctor if you have a history of pancreatitis.

Storage

Store STALIX M XR 100+500 TABLET at a temperature not exceeding 30°C in a cool and dry place, tightly closed in its original container. Keep it out of the reach of children and pets.

STALIX M XR 100+500 TABLET is a combination medication containing Sitagliptin (100mg) and Metformin (500mg) in an extended-release formulation. It is manufactured by Torrent Pharmaceuticals Ltd. This medicine is primarily used for the management of type 2 diabetes mellitus in adults.

What is STALIX M XR 100+500 TABLET used for?

STALIX M XR 100+500 TABLET is used to control high blood sugar levels in adults with type 2 diabetes mellitus. It is typically prescribed when diet and exercise alone are not sufficient to manage blood sugar. This medication helps prevent serious diabetes complications such as kidney damage, eye damage, nerve problems, and may reduce the risk of heart attack or stroke.

How does STALIX M XR 100+500 TABLET work?

This medicine combines two active ingredients: Sitagliptin and Metformin.

• Sitagliptin is a DPP-4 inhibitor. It works by increasing the levels of incretin hormones, which, in turn, increase insulin release from the pancreas after meals and decrease the amount of sugar produced by the liver.
• Metformin is a biguanide. It primarily works by reducing glucose production in the liver, decreasing glucose absorption from the intestines, and improving the body's sensitivity to insulin, allowing it to utilize insulin more effectively. The extended-release (XR) formulation ensures a slow and steady release of the medication, helping to maintain consistent blood sugar control throughout the day.

What is the usual dosage of STALIX M XR 100+500 TABLET?

The usual dosage is one tablet taken orally once or twice daily with meals. It should be swallowed whole and not crushed, chewed, or broken, as this can affect its extended-release properties. Your doctor will determine the right dose based on your blood sugar levels and other medical conditions. It's important to take it at the same time each day for best results.

What are the possible side effects of STALIX M XR 100+500 TABLET?

Common side effects may include nausea, vomiting, diarrhea, stomach pain, loss of appetite, and a metallic taste in the mouth. Other possible side effects include headache, dizziness, upper respiratory tract infection, and rash. A serious but rare side effect is lactic acidosis, characterized by symptoms such as muscle pain, dizziness, cold hands or feet, trouble breathing, and stomach pain. Hypoglycemia (low blood sugar) can also occur, especially if taken with other diabetes medications like insulin or sulfonylureas.

Is STALIX M XR 100+500 TABLET safe during pregnancy or breastfeeding?

STALIX M XR 100+500 TABLET is generally not recommended for use during pregnancy or breastfeeding. Limited human data suggest it may pass into breast milk and harm the baby. Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can STALIX M XR 100+500 TABLET be taken with other medications?

Yes, it can interact with other medications. It is crucial to inform your doctor about all medicines, supplements, or herbal remedies you are currently taking. Specific interactions include:

• Insulin or other antidiabetic medicines: May increase the risk of low blood sugar (hypoglycemia).
• Diuretics (e.g., Furosemide, Hydrochlorothiazide): May increase the risk of lactic acidosis.
• Cationic medicines (e.g., amiloride, digoxin, ranitidine, morphine): May interfere with metformin absorption or elimination.
• Corticosteroids (e.g., hydrocortisone, prednisolone) and oral contraceptives: May affect blood glucose levels.
• NSAIDs (e.g., ibuprofen, celecoxib): May interact.

What precautions should be taken with STALIX M XR 100+500 TABLET?

• Inform your doctor if you have kidney, liver, or heart problems, pancreatitis, or a history of gallstones.
• Avoid consuming alcohol, as it can increase the risk of lactic acidosis and hypoglycemia.
• Regular monitoring of blood sugar levels and kidney function is recommended during treatment.
• Do not stop taking the medicine without consulting your doctor, even if you feel better, as this can cause blood sugar levels to rise.
• This medicine is not recommended for type 1 diabetes, severe kidney disease, severe liver disease, diabetic ketoacidosis, or in cases of severe dehydration.

What happens if a dose is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

How should STALIX M XR 100+500 TABLET be stored?

Store STALIX M XR 100+500 TABLET at room temperature (20-25°C) in a cool and dry place, away from moisture and heat. Keep it out of the sight and reach of children and pets.