Prusent 2 Tablet

PRUSENT 2 TABLET by LUPIN LTD.

Name

• Brand Name: Prusent 2 Tablet
• Common Name: Prucalopride Tablet

Composition

• Active Ingredient: Prucalopride 2 mg

Uses

Prusent 2 Tablet is a prescription medication primarily used for the management of chronic idiopathic constipation (CIC) in adults. CIC is characterized by infrequent, difficult, or incomplete bowel movements lasting three months or more, without any known underlying cause or medication. It is particularly indicated for adults in whom laxatives have not provided sufficient relief. This medicine works as a gastrointestinal prokinetic agent, enhancing intestinal motility, stimulating bowel movements, and promoting gastric emptying of both solid and liquid contents.

Dosage and Administration

The usual recommended dose for adults is 2 mg once daily. Prusent 2 Tablet can be taken orally with or without food, but it is often advised to take it at a fixed time for better results. The tablet should be swallowed whole and not chewed, crushed, or broken. The duration of treatment should be as prescribed by a healthcare professional, as stopping prematurely may lead to symptom recurrence. It is not recommended for children below 18 years of age as safety and effectiveness have not been established.

Side Effects

Common side effects may include:

• Headache
• Diarrhea
• Nausea
• Abdominal pain/stomach cramps
• Dizziness
• Fatigue/Tiredness
• Decreased appetite
• Flatulence
• Dyspepsia (indigestion)

Most of these side effects are usually mild and temporary, resolving over time. If any side effects persist or worsen, it is important to consult a doctor.

Precautions

• Pregnancy and Breastfeeding: Prusent 2 Tablet is not recommended during pregnancy or breastfeeding, as human studies have shown harmful effects on the baby and it may pass into breastmilk. An effective method of contraception should be used while taking this medicine.
• Medical Conditions: Inform your doctor if you have severe kidney disease, severe liver disease, perforation/obstruction of the gut wall, inflammatory conditions of the intestinal tract (like Crohn's disease or ulcerative colitis), or bleeding ulcers of the stomach. Dose adjustments may be necessary for severe kidney or liver impairment.
• Driving and Machinery: This medicine may cause dizziness and tiredness, so it is advisable to avoid driving or operating machinery if you feel affected.
• Alcohol: Limiting alcohol intake is advised as it may intensify dizziness.
• Drug Interactions: Inform your doctor about all other medications, herbal products, or supplements you are taking to prevent potential interactions.
• Children and Elderly: Not recommended for children below 18 years. Use with caution in elderly patients (above 65 years).
• Diarrhea: If diarrhea occurs, it's recommended to drink plenty of fluids to prevent dehydration.

Storage

Store Prusent 2 Tablet in a cool and dry place, away from direct sunlight and moisture. The temperature should not exceed 30°C. Keep this medicine out of sight and reach of children.

What is PRUSENT 2 TABLET used for?

PRUSENT 2 TABLET is primarily used for the management of chronic idiopathic constipation (long-lasting constipation without a known cause) in adults. It is typically prescribed when other laxatives have not provided sufficient relief. This medication helps to increase intestinal motility and stimulate bowel movements.

How does PRUSENT 2 TABLET work?

PRUSENT 2 TABLET contains prucalopride (2 mg) as its active ingredient. It works by activating specific receptors called serotonin 5-HT4 receptors in the walls of your intestines. This activation indirectly increases the release of a chemical messenger called acetylcholine, which promotes contractions and peristalsis (wave-like movements) in the intestines, thereby restoring normal bowel function and relieving constipation.

What is the usual dosage for PRUSENT 2 TABLET?

The usual recommended dose for adults is one 2 mg tablet once daily. It can be taken orally with or without food, at any time of the day. It is important to follow the exact dosage and duration as advised by your doctor, as this may vary based on your condition and response to the medicine.

What are the possible side effects of PRUSENT 2 TABLET?

Common side effects may include headache, nausea, vomiting, abdominal pain, diarrhea, dizziness, fatigue, decreased appetite, flatulence, and dyspepsia (indigestion). Most of these side effects are usually mild and temporary, resolving over time. If any side effects persist or worsen, you should consult your doctor.

Is PRUSENT 2 TABLET safe during pregnancy or breastfeeding?

PRUSENT 2 TABLET is not recommended during pregnancy, and caution is advised. It's important to consult your doctor before taking this medicine if you are pregnant, think you might be pregnant, or are planning a pregnancy. You should use a reliable method of contraception while on this medication.

For breastfeeding women, PRUSENT 2 TABLET is not recommended as limited human data suggests the drug may pass into breast milk and potentially harm the baby.

Can PRUSENT 2 TABLET be taken with other medications?

PRUSENT 2 TABLET can potentially interact with other medications, affecting how they work or being affected by them. It is crucial to inform your doctor about all prescription and over-the-counter medicines, herbal products, and supplements you are currently taking to avoid any possible interactions. For example, prucalopride, the active ingredient, may interact with antihistamines like diphenhydramine.

What precautions should be taken while using PRUSENT 2 TABLET?

You should avoid PRUSENT 2 TABLET if you are allergic to prucalopride or any of its ingredients, or if you have a tear or obstruction in your intestinal wall, or severe inflammatory bowel conditions such as Crohn's disease, ulcerative colitis, or toxic megacolon/megarectum, or if you are on renal dialysis.

Caution is advised if you have existing liver or kidney problems; your doctor may need to adjust the dosage, especially in severe cases. Limit alcohol intake as it may increase side effects like dizziness. This medicine can cause dizziness and tiredness, so it's advisable to avoid driving or operating machinery if you feel affected. It is not recommended for children under 18 years of age. If your constipation does not improve after four weeks of consistent use, consult your doctor.

What happens if a dose of PRUSENT 2 TABLET is missed?

If you forget to take a dose of PRUSENT 2 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. Always consult your doctor for guidance on managing missed doses.

How should PRUSENT 2 TABLET be stored?

PRUSENT 2 TABLET should be stored in a cool, dry place, with the temperature not exceeding 30°C. Protect the medicine from direct light and moisture. Always keep this medicine out of the sight and reach of children.