Sacumada 50 Tablet (14 Tab)

SACUMADA 50 TABLET

SACUMADA 50 TABLET is a medication manufactured by IPCA LABORATORIES LTD, designed to manage chronic heart conditions.

Composition

Each tablet of SACUMADA 50 contains a combination of two active ingredients:

• Sacubitril: 24 mg
• Valsartan: 26 mg

This combination is classified as an Angiotensin Receptor Neprilysin Inhibitor (ARNI).

Uses

SACUMADA 50 TABLET is primarily used to treat chronic heart failure in adults, particularly those with reduced ejection fraction. It helps to reduce the risk of hospitalization and cardiovascular death in affected individuals. The medication works by relaxing and widening blood vessels, making it easier for the heart to pump blood throughout the body, thereby improving heart function and alleviating symptoms like breathlessness, fatigue, and swelling. Some sources also indicate its use in hypertension management and for cardiovascular protection.

Dosage and Administration

SACUMADA 50 TABLET should be taken as prescribed by a physician. It is typically swallowed whole with a glass of water, and should not be chewed, crushed, or broken. The tablet can be taken with or without food, and it is recommended to take it at the same time each day for consistency. The dosage and duration of treatment are determined by the doctor based on the patient's medical condition.

Side Effects

Common side effects may include:

• Dizziness
• Cough
• Headache
• Nausea
• Diarrhea
• Weakness or fatigue
• Low blood pressure (hypotension)
• High potassium levels in the blood (hyperkalemia)
• Kidney dysfunction (renal impairment)

Serious side effects, though rare, can include severe allergic reactions such as angioedema (swelling of the face, lips, tongue, or throat causing breathing difficulties). If severe side effects occur, immediate medical attention is required.

Precautions

• Allergies: Do not take if allergic to Sacubitril, Valsartan, or any other ingredients.
• Drug Interactions: Avoid use with ACE inhibitors (Angiotensin-Converting Enzyme inhibitors) for at least 36 hours before or after taking SACUMADA 50 TABLET due to increased risk of side effects like angioedema. Inform your doctor about all other medications, especially those for blood pressure, heart conditions, or containing aliskiren.
• Medical Conditions: Caution is advised in patients with kidney or liver diseases, diabetes (especially if treated with aliskiren), low blood pressure, or dehydration. Regular monitoring of blood pressure and kidney function is essential.
• Pregnancy and Breastfeeding: Not recommended during pregnancy as it may harm the fetus. Also not recommended for breastfeeding women.
• Children: Not suitable for children and adolescents under 18 years of age.
• Activities: May cause dizziness or tiredness, so avoid driving or operating heavy machinery until you know how the medicine affects you.
• Alcohol: Avoid alcohol consumption as it can increase the risk of low blood pressure and dizziness.

Storage

Store in a cool and dry place, away from direct sunlight and moisture. Keep the medicine out of the sight and reach of children. Do not store above 25°C.

SACUMADA 50 TABLET is a medication primarily prescribed for the treatment of heart failure. It is a combination of two active ingredients, sacubitril and valsartan, which work together to improve heart function and reduce the risk of complications associated with the condition.

What is SACUMADA 50 TABLET used for?

SACUMADA 50 TABLET is used to treat chronic heart failure in adults, particularly those with reduced ejection fraction (HFrEF). It helps reduce the risk of hospitalization and cardiovascular death in these patients. It can also be used in children aged one year and older with symptomatic heart failure.

How does SACUMADA 50 TABLET work?

SACUMADA 50 TABLET is a combination of sacubitril, a neprilysin inhibitor, and valsartan, an angiotensin receptor blocker (ARB). Sacubitril works by inhibiting an enzyme called neprilysin, which leads to increased levels of natural substances in the body (natriuretic peptides) that help relax and widen blood vessels, reduce fluid retention, and lower the heart's workload. Valsartan blocks the action of angiotensin II, a hormone that constricts blood vessels, thereby relaxing and widening blood vessels, lowering blood pressure, and making it easier for the heart to pump blood efficiently. This dual action helps improve heart function and reduces strain on the heart.

What is the usual dosage for SACUMADA 50 TABLET?

The dosage of SACUMADA 50 TABLET is determined by your doctor based on your medical condition and response to treatment. For adults, it is typically taken twice a day, usually one tablet in the morning and one in the evening, roughly 12 hours apart. The tablets should be swallowed whole with a glass of water and not chewed, crushed, or broken. It can be taken with or without food. Your doctor may start you on a lower dose and gradually increase it over 2-4 weeks to find the most effective dose.

What are the possible side effects of SACUMADA 50 TABLET?

Common side effects include low blood pressure (hypotension), dizziness, cough, high potassium levels (hyperkalaemia), and reduced kidney function. Other possible side effects may include nausea, diarrhea, headache, fatigue, and weakness. More serious but rare side effects include angioedema (swelling of the face, lips, tongue, or throat, which can cause difficulty breathing or swallowing). If you experience severe side effects, especially angioedema, seek immediate medical attention.

Is SACUMADA 50 TABLET safe during pregnancy or breastfeeding?

SACUMADA 50 TABLET is generally not recommended during pregnancy as it can cause serious harm or even death to the unborn baby, especially during the last 6 months of pregnancy. It is also not recommended for use during breastfeeding, as there is a risk that the medication could pass into breast milk and harm the baby. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can SACUMADA 50 TABLET be taken with other medications?

SACUMADA 50 TABLET can interact with several other medications. It should not be taken with ACE inhibitors (like enalapril or lisinopril) due to an increased risk of angioedema; there should be a gap of at least 36 hours between stopping an ACE inhibitor and starting SACUMADA 50 TABLET. Concomitant use with aliskiren is also not recommended, especially in patients with diabetes or impaired kidney function. Other medications that may interact include other angiotensin receptor blockers, potassium supplements, potassium-sparing diuretics, NSAIDs (e.g., ibuprofen), and lithium. It is crucial to inform your doctor about all medications, including over-the-counter drugs and supplements, that you are currently taking.

What precautions should be taken while using SACUMADA 50 TABLET?

Inform your doctor about any pre-existing medical conditions, such as kidney or liver problems, diabetes, or a history of angioedema. Regular monitoring of blood pressure, kidney function, and potassium levels will be advised by your doctor. You should get up slowly from a sitting or lying position to avoid dizziness caused by low blood pressure. Alcohol consumption should be limited or avoided as it can worsen low blood pressure and dizziness. If you experience dizziness or tiredness, avoid driving or operating machinery.

What happens if a dose of SACUMADA 50 TABLET is missed?

If you miss a dose of SACUMADA 50 TABLET, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should SACUMADA 50 TABLET be stored?

SACUMADA 50 TABLET should be stored at room temperature, generally below 25°C or 30°C. Keep the tablets in their original packaging to protect them from moisture and light, and ensure they are out of the sight and reach of children.