Pyzina Kid Tabs

PYZINA KID TABS

PYZINA KID TABS is an anti-tuberculosis medicine manufactured by Lupin Ltd.

• Composition:

  • Each tablet contains Pyrazinamide 300 mg.

• Uses:

  • PYZINA KID TABS is primarily prescribed for the treatment and prevention of tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis that mainly affects the lungs but can spread to other body parts.
  • It is typically used in combination with other anti-tuberculosis agents.
  • It may also be used for latent tuberculosis infection, tuberculous meningitis in children, and as prophylaxis in high-risk pediatric populations.
  • The medication works by killing or preventing the growth of the bacteria responsible for tuberculosis.

• Dosage and Administration:

  • The recommended dose is typically 15 to 30 mg/kg once daily.
  • It should be taken with food and a full glass of water.
  • For optimal benefit, it is crucial not to miss doses.
  • Tablets should be swallowed whole and not chewed, crushed, or broken.
  • It can be taken at least 30 minutes before a meal or 2 hours after a meal.

• Side Effects:

  • Common Side Effects: Upset stomach, vomiting, feeling tired or weak, joint pain, loss of appetite, skin rash, itching, and yellow-colored eyes or skin.
  • Serious Side Effects: Harm to the liver (jaundice, hepatitis, increased liver enzymes) may rarely occur. Signs of a severe allergic reaction, such as wheezing, chest tightness, or swelling of the face, lips, tongue, or throat, require immediate medical attention.

• Precautions:

  • Inform your doctor about any allergies to pyrazinamide or other medications.
  • Not recommended for patients with active gout or severe liver disease.
  • Caution is advised in patients with severe kidney disease; dose adjustments may be necessary.
  • Pregnant women should consult their doctor as it may be unsafe during pregnancy (Pregnancy Category C).
  • Breastfeeding women should also consult their doctor, as the medicine is excreted in breast milk.
  • Avoid alcohol consumption during treatment, as it may increase the risk of liver damage.
  • Regular monitoring of liver function tests is advised during treatment.
  • It is important to complete the full course of treatment to prevent treatment failure and bacterial resistance.

• Storage:

  • Store in a cool, dry place away from direct sunlight and the reach of children.
  • Keep in the original packaging and do not use past the expiry date.
  • Typical storage temperature is below 30°C.

What is PYZINA KID TABS used for?

PYZINA KID TABS, containing Pyrazinamide, is an antibiotic used in combination with other anti-tuberculosis (TB) agents to treat and prevent tuberculosis in children. It is effective against active TB infections that primarily affect the lungs but can also involve other parts of the body, and it can also be used for latent TB infection (LTBI) in high-risk pediatric populations.

How does PYZINA KID TABS work?

PYZINA KID TABS functions as an antitubercular medicine by converting into pyrazinoic acid within the body. This active compound inhibits fatty acid synthase I (FAS I), a crucial bacterial enzyme necessary for the growth and replication of Mycobacterium tuberculosis. This action either kills the bacteria or inhibits its growth.

What is the usual dosage for PYZINA KID TABS?

The dosage of PYZINA KID TABS is determined by your doctor based on the child's body weight. For daily therapy, the usual dose is 15 to 30 mg per kilogram of body weight once a day, not exceeding 2 grams daily. For twice-weekly therapy, it can be 50 mg per kilogram, not exceeding 3 grams per day. This medicine is typically administered for the first two months of a multi-drug TB treatment regimen. It can be taken with or without food, preferably at a consistent time each day.

What are the possible side effects of PYZINA KID TABS?

Common side effects may include jaundice, hepatitis (liver inflammation), increased liver enzymes, and joint pain (arthralgia or gout due to elevated uric acid levels). Other reported side effects include loss of appetite, unusual tiredness or weakness, nausea, vomiting, constipation, difficulty passing urine, numbness or tingling in hands/feet, skin rash, itching, urticaria, and photosensitivity. If severe liver impairment is present, the medicine is not recommended.

Is PYZINA KID TABS safe during pregnancy or breastfeeding?

PYZINA KID TABS may be unsafe during pregnancy, as animal studies have shown harmful effects on the developing baby. Your doctor will weigh the potential benefits against the risks before prescribing. During breastfeeding, the medicine is likely safe, as limited human data suggests it does not pose a significant risk to the baby, but consultation with a doctor is still advised.

Can PYZINA KID TABS be taken with other medications?

PYZINA KID TABS must always be administered in combination with other antitubercular drugs. It can interact with several medications, including methotrexate, pexidartinib, pretomanid, and rifampin, potentially leading to increased risk of liver injury or other toxicities. It may also decrease the effectiveness of hormonal contraceptives and affect the activity of live bacterial vaccines. Always inform your doctor about all medications and supplements being taken.

What precautions should be taken while using PYZINA KID TABS?

It is crucial to complete the entire course of treatment, even if symptoms improve, to prevent the infection from returning or becoming drug-resistant. Caution is advised in patients with kidney disease, liver disease, acute gout, or diabetes, and your doctor may adjust the dose or monitor organ function. Regular liver function tests are recommended before and during treatment. Alcohol consumption should be avoided due to the increased risk of adverse liver effects. Additionally, avoid foods high in histamine or tyramine (such as cured meats, aged cheese, soy, tuna, salmon, and mackerel), as they can interact with the medication.

What happens if a dose of PYZINA KID TABS is missed?

If a dose of PYZINA KID TABS is missed, take it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.

How should PYZINA KID TABS be stored?

PYZINA KID TABS should be stored in a cool, dry place, away from direct sunlight and out of the reach of children. The recommended storage temperature is typically below 30°C or between 10°C to 25°C.