Coversyl Plus Tablet (10 Tab)

COVERSYL PLUS TABLET

COVERSYL PLUS TABLET is a combination medication used to manage high blood pressure. It is available in various strengths, such as 2.5 mg/0.625 mg, 5 mg/1.25 mg, and 10 mg/2.5 mg, referring to its active ingredients.

• Composition: Each tablet contains Perindopril arginine, an Angiotensin Converting Enzyme (ACE) inhibitor, and Indapamide, a chlorosulphamoyl diuretic (often referred to as a "water pill"). Perindopril works by relaxing blood vessels, while Indapamide helps the body excrete excess salt and water.

• Uses: Primarily prescribed for the treatment of essential hypertension (high blood pressure). It is used when blood pressure is not adequately controlled by perindopril alone or as a substitution therapy for patients already controlled on both components given concurrently. This helps reduce the heart's workload and lowers the risk of future heart attack or stroke.

• Dosage and Administration: The typical dosage is one tablet once daily, preferably in the morning before a meal. It is crucial to take this medicine regularly as directed by a healthcare professional and not to discontinue it abruptly, even if blood pressure normalizes.

• Side Effects: Common side effects may include dizziness, headache, a dry cough, nausea, vomiting, diarrhea, stomach pain, muscle cramps, fatigue, and low blood pressure (hypotension). Serious side effects, though rare, can include angioedema (severe allergic reaction with swelling of the face, lips, tongue, or throat), severe kidney or liver problems, and significant electrolyte imbalances (e.g., changes in potassium levels).

• Precautions: COVERSYL PLUS is contraindicated in patients with hypersensitivity to its ingredients, a history of angioedema related to ACE inhibitor therapy, severe renal impairment (creatinine clearance below 30 mL/min or 60 mL/min depending on strength), severe hepatic impairment, during the second and third trimesters of pregnancy, and while breastfeeding. Caution is advised in elderly patients, those with diabetes, congestive heart failure, or renovascular hypertension. Concomitant use with sacubitril/valsartan is contraindicated. Regular monitoring of blood pressure, kidney function, and electrolyte levels is recommended. May cause drowsiness or dizziness, affecting the ability to drive or operate machinery.

• Storage: Store COVERSYL PLUS tablets in a dry place, below 30°C, and keep the container tightly closed to protect from moisture and light. Keep out of reach of children.

COVERSYL PLUS TABLET: Frequently Asked Questions

What is COVERSYL PLUS TABLET used for?

COVERSYL PLUS TABLET is primarily used to treat essential hypertension (high blood pressure) in adults. It is prescribed when blood pressure is not adequately controlled by a single medication. This medicine helps reduce the risk of future heart attacks and strokes. It can also reduce excess fluid overload in the body and treat swelling (oedema) associated with heart, liver, kidney, or lung disease.

How does COVERSYL PLUS TABLET work?

COVERSYL PLUS TABLET contains two active ingredients: perindopril arginine and indapamide. Perindopril is an Angiotensin-Converting Enzyme (ACE) inhibitor that works by relaxing blood vessels and making it easier for the heart to pump blood efficiently. Indapamide is a diuretic (often called a "water pill") that helps control blood pressure by increasing the amount of urine passed out from the kidneys, thus getting rid of excess salt and water from the body. These two components work together to provide an additive antihypertensive effect.

What is the usual dosage for COVERSYL PLUS TABLET?

The usual recommended dose is one tablet once daily, preferably taken in the morning before a meal. Your doctor will determine the appropriate dose based on your condition and response to the medicine. Do not stop taking this medicine or change your dose without consulting your doctor.

What are the possible side effects of COVERSYL PLUS TABLET?

Common side effects can include dizziness, headache, tiredness, nausea, vomiting, diarrhea, constipation, stomach pain, muscle cramps, a dry cough, and changes in taste. More serious, but less common, side effects include severe dizziness or fainting (due to low blood pressure), severe allergic reactions like angioedema (swelling of the face, lips, tongue, or throat which can cause difficulty breathing), and kidney or liver problems. If you experience any severe or persistent side effects, seek immediate medical attention.

Is COVERSYL PLUS TABLET safe during pregnancy or breastfeeding?

COVERSYL PLUS TABLET is generally unsafe during pregnancy and is contraindicated, especially during the second and third trimesters, as it can cause serious harm or be fatal to the developing baby. It is also not recommended during early pregnancy. For breastfeeding, the use of COVERSYL PLUS TABLET is generally not recommended as perindopril passes into breast milk, and it is unknown if indapamide does as well. Always consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Can COVERSYL PLUS TABLET be taken with other medications?

COVERSYL PLUS TABLET can interact with several other medications. It is important to inform your doctor about all medicines you are taking, including over-the-counter drugs, supplements, and herbal remedies. Some medications that may interact include other blood pressure-lowering agents (like ARBs or aliskiren), diuretics (especially potassium-sparing ones), potassium supplements, lithium, nonsteroidal anti-inflammatory drugs (NSAIDs), certain steroids, medicines for heart rhythm problems, and drugs that can increase potassium levels. Concomitant use with sacubitril/valsartan is contraindicated due to an increased risk of angioedema.

What precautions should be taken while taking COVERSYL PLUS TABLET?

Before taking COVERSYL PLUS TABLET, inform your doctor if you have kidney or liver problems, diabetes, gout, heart conditions, or a history of allergic reactions. Regular monitoring of blood pressure, kidney function, and electrolyte levels (like potassium) is usually recommended. You should avoid consuming alcohol, as it may increase dizziness and low blood pressure. This medicine may cause dizziness or drowsiness, so exercise caution when driving or operating machinery, especially when starting the medication or increasing the dose.

What happens if a dose of COVERSYL PLUS TABLET is missed?

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten one. Take the next dose at the usual time. Regular treatment is more effective, so try to take it every day.

How should COVERSYL PLUS TABLET be stored?

Store COVERSYL PLUS TABLET in a cool, dry place where the temperature stays below 30°C, away from light and moisture. Keep the container tightly closed and out of the reach of children. Do not store medicines in a bathroom or near a sink, and do not leave them in a car or on a windowsill.