Gravitor Sr Tablet (10 Tab)

GRAVITOR SR TABLET

GRAVITOR SR TABLET is a medication primarily used to manage conditions affecting muscle strength and function. It is manufactured by SUN PHARMA LABORATORIES LTD.. The "SR" in its name indicates a sustained-release formulation, designed for gradual and consistent release of the active ingredient.

Composition

GRAVITOR SR TABLET contains Pyridostigmine as its active ingredient, typically in a strength of 180 mg. Pyridostigmine is a cholinesterase inhibitor that works by preventing the breakdown of acetylcholine, a neurotransmitter crucial for nerve-muscle communication. This action increases acetylcholine levels at nerve endings, thereby enhancing muscle contraction and improving muscle strength.

Uses

GRAVITOR SR TABLET is prescribed for several medical conditions:

• Myasthenia Gravis: A long-term neuromuscular disease characterized by muscle weakness and fatigue. It helps improve muscle strength and reduce symptoms.
• Paralytic Ileus: A condition where intestinal muscles become paralyzed, hindering digestive movement and leading to constipation. It stimulates intestinal muscle contractions to promote food movement.
• Postoperative Urinary Retention: Difficulty in emptying the bladder after surgery due to nerve and muscle coordination issues. It aids in stimulating bladder muscle contractions for complete emptying.
• Reversal of Neuromuscular Blockade: Used after surgery to reverse the effects of non-depolarizing muscle relaxants.
• Prophylaxis against Nerve Poisoning Gas: Approved for prophylactic use against exposure to nerve agents like soman, particularly in military preparedness.

Dosage and Administration

GRAVITOR SR TABLET should be taken orally, typically on an empty stomach, preferably at the same time each day, or 30-60 minutes before food. It should be swallowed whole with a glass of water and not chewed, crushed, or broken.

• Myasthenia Gravis (Adults): Typical adult dosage ranges from 0.3-1.2 g daily in divided doses.
• Myasthenia Gravis (Children): For children less than 6 years, an initial dose of 30 mg; for children 6-12 years, an initial dose of 60 mg. The dose may be gradually increased by 15-30 mg daily until a satisfactory response. For neonatal myasthenia gravis, 5-10 mg given every 4-6 hours.
• Paralytic Ileus and Postoperative Urinary Retention (Adults): Doses of 60-240 mg.

Always adhere to the doctor's prescribed dosage and duration, and do not stop the medication suddenly.

Side Effects

Common side effects may include:

• Stomach pain, abdominal cramps
• Nausea, vomiting, diarrhea
• Excessive salivation (drooling)
• Sweating
• Cough with mucus, increased bronchial secretions
• Rash, muscle cramps, muscle twitching, muscle weakness
• Blurred vision, watery eyes, increased sensitivity to light
• Headache, dizziness, sleepiness
• Altered frequency of urination
• Runny nose, heartburn, gastro-esophageal reflux disease
• Paresthesia (tingling or pricking sensation)

Serious side effects, especially with overdose, can include severe muscle weakness, difficulty breathing, and even paralysis. Consult a doctor if side effects persist or worsen.

Precautions

• Allergies: Do not take if allergic to pyridostigmine or any other ingredients.
• Medical Conditions: Inform your doctor if you have kidney problems, Parkinson's disease, asthma, high blood pressure, glaucoma, breathing problems, coronary obstruction, stomach ulcers, epilepsy, hyperthyroidism, bradycardia, or have had recent thymus gland surgery. It is contraindicated in cases of bladder or bowel obstruction.
• Pregnancy and Breastfeeding: Generally considered safe during pregnancy if prescribed by a doctor. Small amounts may pass into breast milk, so consult a doctor if breastfeeding.
• Alcohol: Avoid consuming alcohol as it may intensify side effects like dizziness and drowsiness.
• Driving and Machinery: May cause dizziness and vision problems, so avoid driving or operating machinery if you are not alert.
• Drug Interactions: Inform your doctor about all medications you are taking, including cholinergic agents, beta-blockers, aminoglycoside antibiotics, anticholinergic drugs, and corticosteroids, as they can interact with Gravitor SR Tablet.
• Age: Not approved for use by anyone younger than 18 years old unless prescribed by a doctor, with dosage depending on the child's age.

Storage

Store in a cool and dry place away from sunlight, typically between 10ºC to 25ºC or below 30ºC. Keep out of sight and reach of children. Do not freeze the tablets.

What is Gravitor SR Tablet used for?

Gravitor SR Tablet is primarily used to treat Myasthenia Gravis, a condition characterized by muscle weakness and fatigue. It is also prescribed for paralytic ileus, which is the paralysis of intestinal muscles, and for postoperative urinary retention, an inability to urinate after surgery. Additionally, it may be used as a prophylactic measure against military exposure to certain nerve agents.

How does Gravitor SR Tablet work?

Gravitor SR Tablet contains Pyridostigmine, which belongs to a class of medicines called cholinesterase inhibitors. It works by preventing the breakdown of acetylcholine, a chemical messenger vital for communication between nerve impulses and muscle movements. By increasing the availability of acetylcholine, it helps to improve muscle contraction and strengthen muscles.

What is the usual dosage for Gravitor SR Tablet?

The dosage of Gravitor SR Tablet is determined by your doctor based on the specific condition being treated and your individual response. It is recommended to take the tablet on an empty stomach, preferably at the same time each day, as prescribed by your doctor. The tablet should be swallowed whole with a glass of water and not chewed, crushed, or broken.

What are the possible side effects of Gravitor SR Tablet?

Common side effects can include stomach pain, nausea, vomiting, diarrhea, abdominal cramps, excessive salivation, sweating, headache, dizziness, and blurred vision. Other possible side effects may include muscle cramps, muscle twitching, shortness of breath, watery eyes, altered frequency of urination, runny nose, heartburn, and a tingling or pricking sensation (paresthesia). If any of these side effects persist or worsen, consult your doctor.

Is Gravitor SR Tablet safe during pregnancy or breastfeeding?

Gravitor SR Tablet is generally considered safe to use during pregnancy if prescribed by a doctor, though limited human studies are available. Caution is advised, and you should inform your doctor if you are pregnant or planning to conceive. A small amount of the active ingredient may pass into breast milk, so it's advisable to consult your doctor before using this medication while breastfeeding.

Can Gravitor SR Tablet be taken with other medications?

Gravitor SR Tablet can interact with other medications. For instance, cholinergic agents may increase its effects, while beta-blockers could lead to a slower heart rate. Aminoglycoside antibiotics might enhance its muscle-blocking effect, and anticholinergic drugs can reduce its effectiveness. Corticosteroids may also worsen symptoms of myasthenia gravis when taken concurrently. Always inform your doctor about all prescription drugs, non-prescription drugs, and herbal supplements you are taking to avoid potential interactions.

What precautions should be taken while using Gravitor SR Tablet?

Before taking Gravitor SR Tablet, inform your doctor if you have kidney problems, Parkinson's disease, asthma, stomach disorders, high blood pressure, glaucoma, epilepsy, peptic ulcer disease, or hyperthyroidism. Due to potential dizziness and blurred vision, avoid driving or operating heavy machinery until you know how the medication affects you. Alcohol consumption should also be avoided as it may intensify side effects. Do not stop taking the medicine suddenly without consulting your doctor.

What happens if a dose of Gravitor SR Tablet is missed?

If you miss a dose of Gravitor SR Tablet, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to compensate for a missed one.

How should Gravitor SR Tablet be stored?

Gravitor SR Tablet should be stored in a cool, dry place, away from direct sunlight and moisture, at a temperature between 10ºC to 25ºC or below 30ºC. Keep it out of sight and reach of children, and do not freeze the medication.