Justoza M 10/500mg15tab

JUSTOZA M 10/500MG15TAB by MANKIND-TEMPLAR DIV.

Name

• Brand Name: Justoza M 10/500 Tablet ER (Extended Release)
• Common Name: Dapagliflozin and Metformin Hydrochloride Extended-Release Tablets

Composition

Justoza M 10/500 Tablet ER is a combination of two active antidiabetic medicines:

• Dapagliflozin (10 mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by reducing the reabsorption of glucose in the kidneys, leading to increased glucose excretion through urine and thereby lowering blood sugar levels.
• Metformin (500 mg): This is a biguanide. It primarily works by decreasing glucose production in the liver, delaying glucose absorption from the intestines, and increasing the body's sensitivity to insulin.

Uses

Justoza M 10/500 Tablet ER is used to treat adults with type 2 diabetes mellitus. It helps control high blood sugar levels when diet and exercise alone are insufficient. This medication also helps reduce the risk of serious complications of diabetes, including kidney damage, blindness, and nerve damage. Additionally, it may reduce the risk of hospitalization for heart failure in type 2 diabetic patients with established cardiovascular disease or multiple risk factors.

Dosage and Administration

This medication should be taken exactly as prescribed by a doctor. It is typically taken with food, preferably at the same time every day, to minimize gastrointestinal side effects and ensure consistent efficacy. The tablet should be swallowed whole and not chewed, crushed, or broken. The exact dosage and duration will be determined by the physician based on the patient's medical condition and response to treatment.

Side Effects

Common Side Effects:

• Sore throat, nasal congestion, runny nose, nasopharyngitis
• Headache, dizziness
• Nausea, vomiting, diarrhea, abdominal pain
• Urinary tract infections (UTIs)
• Genital fungal infections (in both males and females)
• Increased urination
• Back pain
• Taste change, skin rash

Serious Side Effects:

• Hypoglycemia (low blood sugar), especially when used with other antidiabetic medicines or alcohol
• Dehydration
• Lactic acidosis (a rare but serious metabolic complication)

Precautions

• Kidney and Liver Impairment: Use with caution in patients with kidney or liver disease. It is not recommended for severe kidney problems.
• Pregnancy and Breastfeeding: Consult a doctor, as it may be unsafe during pregnancy and is generally not recommended during breastfeeding.
• Alcohol: Avoid excessive alcohol intake, as it may increase the risk of lactic acidosis and other side effects.
• Dehydration: Drink plenty of fluids to prevent dehydration, especially due to increased urination.
• Infections: Maintain good hygiene to reduce the risk of genital and urinary tract infections.
• Interactions: Inform your doctor about all other medications, including over-the-counter drugs and herbal supplements, to avoid potential drug interactions. Specific interactions can occur with diuretics, insulin, insulin secretagogues, and certain injectable dyes.
• Monitoring: Regular monitoring of blood sugar levels and kidney function is essential during treatment.
• Elderly Patients: Use with caution in elderly patients as they may be more susceptible to side effects.
• Type 1 Diabetes: Not indicated for type 1 diabetes mellitus.

Storage

Store Justoza M 10/500 Tablet ER in a cool and dry place, away from sunlight. The recommended storage temperature is below 30°C (or between 10°C to 25°C). Keep out of sight and reach of children.

Here are frequently asked questions about JUSTOZA M 10/500MG15TAB:

What is JUSTOZA M 10/500MG used for?

JUSTOZA M 10/500MG is a combination medicine primarily used to manage type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet and exercise alone are not sufficient. Additionally, it can reduce the risk of hospitalization for heart failure in type 2 diabetic patients who have established cardiovascular disease or multiple risk factors.

How does JUSTOZA M 10/500MG work?

This medication contains two active ingredients: Dapagliflozin (10 mg) and Metformin (500 mg). Dapagliflozin, an SGLT2 inhibitor, works by making the kidneys remove excess glucose from the bloodstream through urine. Metformin, a biguanide, decreases glucose production by the liver and reduces intestinal absorption of glucose, while also improving the body's sensitivity to insulin.

What is the usual dosage of JUSTOZA M 10/500MG?

The dosage of JUSTOZA M 10/500MG is determined by your doctor based on your medical condition and response to treatment. It is typically taken once or twice daily with meals to minimize gastrointestinal side effects. The tablet should be swallowed whole with a glass of water and not crushed, chewed, or broken.

What are the possible side effects of JUSTOZA M 10/500MG?

Common side effects may include upper respiratory tract infections, female genital mycotic infections (fungal infections), nasopharyngitis (inflammation of nasal passages and throat), urinary tract infection, diarrhea, headache, nausea, and back pain. Serious but rare side effects can include lactic acidosis. If symptoms persist or worsen, consult your doctor.

Is JUSTOZA M 10/500MG safe during pregnancy or breastfeeding?

JUSTOZA M 10/500MG is generally not recommended during pregnancy and breastfeeding. Caution is advised if you are pregnant, and it is considered unsafe during breastfeeding as it may excrete via breast milk. Always consult your doctor for advice on potential risks and benefits.

Can JUSTOZA M 10/500MG be taken with other medications?

This medicine can interact with other medications. Combining it with sulfonylureas (like Gliclazide) may increase the risk of hypoglycemia (low blood sugar levels). Co-administration with NSAIDs (like Ibuprofen) may decrease the effectiveness of metformin and increase the risk of lactic acidosis. Diuretics (water pills) can increase the risk of dehydration and low blood pressure. It should not be used if you are undergoing an X-ray with iodinated contrast agents. Always inform your doctor about all other medications, supplements, or herbal products you are taking to avoid potential interactions.

What precautions should be taken while using JUSTOZA M 10/500MG?

You should inform your doctor if you have kidney or liver problems, urinary tract infections, a history of dehydration, low blood pressure, or are on water pills. Excessive alcohol intake should be avoided as it can increase the risk of lactic acidosis. Regular monitoring of blood sugar levels is essential during treatment.

What happens if a dose of JUSTOZA M 10/500MG is missed?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to compensate for the missed one.

How should JUSTOZA M 10/500MG be stored?

JUSTOZA M 10/500MG should be stored below 30°C in a cool and dry place. Keep it away from direct sunlight, moisture, and out of sight and reach of children.