Nusam (new) 400 Mg Tablet (10 Tab)

NUSAM (NEW) 400 MG TABLET

NUSAM (NEW) 400 MG TABLET is a medication manufactured by Sun Pharmaceutical Industries Ltd., primarily used to support liver health and address various related conditions.

• Name:

  • Common Name: S-Adenosyl-L-Methionine (SAMe), Ademetionine
  • Brand Name: New Nusam 400 Tablet, NUSAM (NEW) 400 MG TABLET

• Composition:

  • Each tablet contains Ademetionine (or S-Adenosyl-L-Methionine) 400mg.

• Uses: NUSAM (NEW) 400 MG TABLET is prescribed for a range of medical conditions, primarily focusing on liver health and mood regulation.

  • Liver Disorders: It is widely used in the management of chronic liver diseases such as intrahepatic cholestasis (a condition with reduced bile flow), cirrhosis, hepatitis, and alcoholic liver disease. It protects liver cells from toxins, supports bile flow, restores liver enzymes, and enhances detoxification processes. It may also be used for intrahepatic cholestasis of pregnancy (ICP).
  • Depression and Mood Disorders: Ademetionine plays a role in producing neurotransmitters like serotonin and dopamine, helping to improve mood, reduce depressive symptoms, and enhance mental well-being, including anxiety.
  • Musculoskeletal Conditions: It can help reduce joint pain and stiffness in conditions like osteoarthritis and may alleviate symptoms of fibromyalgia.

• Dosage and Administration:

  • Take NUSAM (NEW) 400 MG TABLET exactly as prescribed by your doctor.
  • The tablet should be swallowed whole with water, without chewing, crushing, or breaking it.
  • It can generally be taken with or without food, though some sources suggest taking it before meals for better absorption.
  • The dosage and duration depend on the individual's medical condition, body weight, and response to treatment.
  • Consistent intake, preferably at the same time each day, is crucial for optimal benefits, and treatment may extend for several months or longer. Do not discontinue without consulting your doctor, even if symptoms improve.

• Side Effects: Most side effects are mild and temporary. Consult your doctor if they persist or worsen.

  • Common Side Effects: Nausea, diarrhea, upset stomach, abdominal discomfort/pain, constipation, dizziness, headache, insomnia, bloating, dry mouth.
  • Serious Side Effects (Rare): Mood changes, worsening of bipolar symptoms, severe allergic reactions (rash, itching, swelling), or symptoms of serotonin syndrome (e.g., agitation, hallucinations, rapid heart rate, confusion).

• Precautions:

  • Inform your doctor if you are allergic to Ademetionine or any other ingredients.
  • Consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding. Use during these periods should only be if clearly needed and advised by a healthcare professional.
  • Exercise caution if you have a history of bipolar disorder, as this medicine may trigger mania/hypomania or worsen the condition.
  • Patients with moderate to severe kidney problems should not use this tablet, and those with mild kidney issues should use it cautiously.
  • Avoid consuming alcohol, as it may worsen liver problems and increase side effects.
  • If you experience dizziness, avoid driving or operating heavy machinery.
  • Disclose all other medications, including over-the-counter drugs, supplements, and herbal remedies, to your doctor to avoid potential drug interactions (e.g., with antidepressants, anti-Parkinsonian drugs, or those affecting serotonin levels).
  • Patients with folate or Vitamin B12 deficiency should inform their doctor.
  • Not recommended for children under 18 years due to insufficient safety and efficacy data, use with extreme caution if prescribed.
  • Regular monitoring of liver function and vitamin levels may be advised by your doctor.
  • Use with caution in elderly patients, as they may have an increased risk of side effects.

• Storage:

  • Store in a cool and dry place, preferably below 30°C, and away from direct sunlight.
  • Keep out of reach and sight of children.

Here are the most frequently asked questions about NUSAM (NEW) 400 MG TABLET (10 TAB) by SUN PHARMA LABORATORIES LTD., which contains Ademetionine (also known as S-Adenosyl-L-Methionine or SAMe):

What is NUSAM (NEW) 400 MG TABLET used for?

NUSAM (NEW) 400 MG TABLET is primarily used for the treatment of various liver disorders, including intrahepatic cholestasis (reduced bile flow from the liver), alcoholic liver disease, cirrhosis, and hepatitis. It is also used to manage symptoms of osteoarthritis, depression, and fibromyalgia. Some sources also mention its use for liver disease during pregnancy and biliary cholangitis.

How does NUSAM (NEW) 400 MG TABLET work?

The active ingredient, Ademetionine (S-Adenosyl-L-Methionine or SAMe), is a naturally occurring compound in the body that plays a vital role in numerous biochemical processes. It acts as a methyl group donor, involved in regulating hormones, neurotransmitters (like serotonin and dopamine), and maintaining cell membranes. In the liver, it helps promote cell regeneration, reduces inflammation, supports detoxification by maintaining glutathione levels, and improves bile flow. For osteoarthritis, it stimulates cartilage production, reducing pain and inflammation.

What is the usual dosage for NUSAM (NEW) 400 MG TABLET?

The dosage of Ademetionine can vary depending on the condition being treated and individual needs. For depression, studies have shown dosages ranging from 200 mg to 1,600 mg daily, sometimes starting with lower doses and gradually increasing. For osteoarthritis, 600 mg to 1,200 mg daily, divided into multiple doses, is common. In chronic liver conditions, 800 mg to 1,200 mg daily has been studied. It is crucial to follow your doctor's instructions regarding the specific dosage and duration.

What are the possible side effects of NUSAM (NEW) 400 MG TABLET?

Side effects are generally mild and uncommon. They can include gastrointestinal issues such as nausea, diarrhea, stomach pain or discomfort, flatulence, and constipation. Other reported side effects may include dry mouth, headache, dizziness, mild insomnia, irritability, and anxiety. If these side effects persist or worsen, consult your doctor.

Is NUSAM (NEW) 400 MG TABLET safe during pregnancy or breastfeeding?

While Ademetionine has been used to treat intrahepatic cholestasis during pregnancy, its overall safety during pregnancy and breastfeeding is not fully established, and data on long-term safety are limited. It is crucial to consult your doctor before using this medication if you are pregnant, planning to become pregnant, or breastfeeding.

Can NUSAM (NEW) 400 MG TABLET be taken with other medications?

Ademetionine can interact with several medications. It should be used with caution and under medical supervision if you are taking:

• Antidepressants: (SSRIs, MAOIs, TCAs) as combining them can increase serotonin levels and potentially lead to serotonin syndrome.
• Anti-Parkinson's drugs: Especially levodopa, as Ademetionine may decrease its effectiveness.
• Antipsychotics, certain painkillers (e.g., tramadol, methadone, meperidine), and anti-migraine triptans: These can also increase the risk of serotonin syndrome when taken with Ademetionine. Always inform your doctor about all medications, supplements, and herbal products you are currently taking.

What precautions should be taken while using NUSAM (NEW) 400 MG TABLET?

• Bipolar Disorder: Individuals with bipolar disorder should not take Ademetionine except under strict medical supervision, as it may worsen symptoms of mania and can precipitate manic episodes.
• Compromised Immune System: People who are immunocompromised (e.g., HIV-positive) should use caution, as Ademetionine might enhance the growth of certain microorganisms like Pneumocystis carinii.
• Liver/Kidney Conditions: Exercise caution and inform your doctor if you have severe liver problems (like liver failure) or kidney issues.
• Genetic Defects: It is contraindicated in individuals with known genetic defects such as vitamin B12 metabolism defects and cystathionine beta-synthase deficiency.
• Alcohol: Avoid consuming alcohol while taking this medication as it may increase the likelihood of side effects and liver damage.
• Allergies: Do not take if you are allergic to Ademetionine or any other ingredients in the tablet.

What happens if a dose of NUSAM (NEW) 400 MG TABLET is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should NUSAM (NEW) 400 MG TABLET be stored?

Store the tablets in a tightly sealed container in a cool, dry place, protected from light and moisture. Do not remove the tablets from their blister pack until you are ready to use them. For long-term storage, low temperatures (e.g., refrigerated or -20°C to -80°C) are often recommended for the active ingredient, Ademetionine, to prevent degradation.