Zoryl M Forte 1 Mg Tablet (15 Tab)

ZORYL M FORTE 1 MG TABLET

ZORYL M FORTE 1 MG TABLET is a combination oral anti-diabetic medication manufactured by Intas Pharmaceuticals Ltd., primarily used for the management of Type 2 Diabetes Mellitus.

• Name:

  • Brand Name: ZORYL M FORTE 1 MG TABLET
  • Common Name: Glimepiride and Metformin Hydrochloride Tablet

• Composition: Each film-coated tablet contains:

  • Glimepiride: 1 mg
  • Metformin Hydrochloride: 1000 mg (in extended-release form)

• Uses: ZORYL M FORTE 1 MG TABLET is prescribed for adults with Type 2 Diabetes Mellitus to improve glycemic control. It is particularly indicated when blood sugar levels are not adequately controlled by diet and exercise alone, or by monotherapy with either glimepiride or metformin. This medication helps to lower blood sugar levels and can reduce the risk of diabetes-related complications such as kidney damage, eye problems, nerve issues, and cardiovascular diseases.

• Dosage and Administration: The tablet should be taken as directed by a healthcare professional, usually once daily with meals, preferably with breakfast or the first main meal of the day. It is crucial to swallow the tablet whole with a glass of water and avoid crushing or chewing it, as it is an extended-release formulation. The dosage is individualized based on the patient's condition, severity, and response to treatment. Do not exceed the prescribed dose.

• Side Effects: Common side effects may include:

  • Hypoglycemia (low blood sugar), which can manifest as sweating, dizziness, headache, or shaking.
  • Diarrhoea, nausea, vomiting
  • Abdominal discomfort, stomach pain
  • Flatulence, altered taste (metallic taste)
  • Headache
  • Upper respiratory tract infection, urinary tract infection Serious but rare side effects include lactic acidosis (an excess of lactic acid in the blood), which requires immediate medical attention and symptoms like muscle pain, weakness, difficulty breathing, and stomach pain. Long-term use may also lead to vitamin B12 deficiency.

• Precautions:

  • Hypoglycemia: Patients should be aware of the signs of low blood sugar and carry a fast-acting source of glucose. Taking the medicine with a main meal can help prevent low blood sugar.
  • Alcohol: Avoid alcohol consumption as it increases the risk of lactic acidosis and can affect blood sugar levels.
  • Pregnancy and Breastfeeding: Not recommended during pregnancy and caution is advised in breastfeeding mothers.
  • Medical Conditions: Inform your doctor about any history of liver or kidney problems, heart disease, type 1 diabetes, or diabetic ketoacidosis. ZORYL M FORTE 1 MG TABLET is contraindicated in severe renal impairment.
  • Interactions: Thiazides, corticosteroids, and phenothiazines can increase blood sugar levels and reduce the effectiveness of this medicine.
  • Surgery: Inform your doctor about your diabetes treatment if you are due for surgery under general anesthetic.
  • Children: Not suitable for use in children and adolescents under 18 years of age.
  • Allergy: Do not take if allergic to glimepiride, metformin, or any other components.

• Storage: Store in a cool, dry, and dark place, protected from light and moisture, and below 30°C (or between 10ºC to 25ºC). Keep out of the reach and sight of children and pets. Store in the original container, tightly closed.

Here are the most frequently asked questions about ZORYL M FORTE 1 MG TABLET:

What is ZORYL M FORTE 1 MG TABLET used for?

ZORYL M FORTE 1 MG TABLET is primarily used to manage Type 2 diabetes mellitus in adults. It is a combination therapy that helps control high blood sugar levels, especially when diet, exercise, and single-agent medications like glimepiride or metformin alone are not sufficient. This medicine aids in maintaining optimal blood sugar levels and can help reduce the risk of diabetes-related complications such as kidney damage, eye problems, nerve issues, and loss of limbs.

How does ZORYL M FORTE 1 MG TABLET work?

ZORYL M FORTE 1 MG TABLET contains two active ingredients: Glimepiride (1 mg) and Metformin (1000 mg).

• Glimepiride belongs to the sulfonylurea class of drugs. It works by stimulating the beta cells in the pancreas to produce and release more insulin, which helps lower blood sugar levels.
• Metformin is a biguanide. It primarily works by reducing the amount of glucose produced by the liver, decreasing glucose absorption from the intestines, and enhancing the body's sensitivity to insulin, thereby improving peripheral glucose uptake and utilization. Together, these components provide a dual-action approach to effectively manage blood sugar.

What is the usual dosage of ZORYL M FORTE 1 MG TABLET?

The dosage of ZORYL M FORTE 1 MG TABLET is individualized by your doctor based on factors like the severity of your condition and your response to the medicine. It is typically taken once daily with meals, preferably with breakfast or the first main meal of the day. It is crucial to swallow the tablet whole with water and avoid crushing or chewing it, as it may be an extended-release formulation. Always adhere to the prescribed dosage and never exceed it without consulting your doctor.

What are the possible side effects of ZORYL M FORTE 1 MG TABLET?

Common side effects include:

• Hypoglycaemia (low blood sugar levels), which can manifest as sweating, dizziness, headache, and shaking.
• Gastrointestinal issues such as diarrhoea, nausea, vomiting, stomach pain, flatulence, and abdominal discomfort.
• Headache
• Taste disturbance or a metallic taste.
• Weight gain.

Serious but rare side effects can include lactic acidosis (an accumulation of lactic acid in the blood), especially in patients with kidney problems, and vitamin B12 deficiency with long-term use. If you experience any severe or persistent side effects, consult your doctor immediately.

Is ZORYL M FORTE 1 MG TABLET safe during pregnancy or breastfeeding?

No, ZORYL M FORTE 1 MG TABLET is generally not recommended during pregnancy as it may harm the unborn baby. Insulin therapy is often preferred for managing diabetes in pregnant women.

Regarding breastfeeding, caution is advised as it is unclear whether the medicine passes into breast milk. Some sources indicate it passes in very small quantities, but potential adverse effects on the baby, such as hypoglycemia, are a concern. It is best to avoid ZORYL M FORTE 1 MG TABLET while breastfeeding and discuss the risks and benefits with your doctor.

Can it be taken with other medications?

ZORYL M FORTE 1 MG TABLET can interact with various medications, which can either increase blood sugar levels (reducing its effectiveness) or increase the risk of hypoglycemia or lactic acidosis. Inform your doctor about all medications, supplements, and herbal products you are taking.

Some medications that may interact include:

• Thiazides, Corticosteroids, Phenothiazines: Can increase blood sugar levels.
• Alcohol: Increases the risk of lactic acidosis and can cause low blood sugar.
• Certain antibiotics (e.g., rifampicin, trimethoprim), antifungals (e.g., fluconazole), antacids (e.g., cimetidine), and some heart medications (e.g., verapamil, ranolazine): Can interact with the active ingredients.
• Iodinated contrast agents: May lead to renal failure and increased risk of metformin accumulation and lactic acidosis.
• Other antidiabetic drugs: Can increase the risk of hypoglycemia.

What precautions should be taken?

• Hypoglycemia: Be aware of the symptoms of low blood sugar (sweating, dizziness, headache, shaking) and always carry a fast-acting source of glucose (like sugary food or fruit juice). Eating regular meals is important.
• Alcohol Consumption: Avoid alcohol as it can increase the risk of lactic acidosis and severe hypoglycemia.
• Kidney and Liver Issues: This medicine should be used with caution in patients with kidney or liver disease, and it is contraindicated in severe renal impairment. Regular monitoring of kidney and liver function may be necessary.
• Dehydration: Avoid dehydration, as it can increase the risk of lactic acidosis.
• Type 1 Diabetes and Diabetic Ketoacidosis: ZORYL M FORTE 1 MG TABLET is not suitable for Type 1 diabetes or diabetic ketoacidosis.
• Allergies: Do not take if you are allergic to glimepiride, metformin, or any other components of the tablet.
• Driving and Machinery: Your ability to drive or operate machinery may be affected if your blood sugar is too low or too high.
• Children: It is not suitable for use in children and adolescents under 18 years of age.
• Grapefruit Juice: Avoid consuming grapefruit juice while taking this medication.

What happens if a dose is missed?

If you miss a dose of ZORYL M FORTE 1 MG TABLET, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one. Never alter your dosage without consulting your doctor.

How should it be stored?

ZORYL M FORTE 1 MG TABLET should be stored in a cool, dry, and dark place, away from direct sunlight and moisture. Keep it in its original container or pack, tightly closed, and out of the reach and sight of children and pets. The recommended storage temperature is typically between 10ºC to 25ºC or below 30ºC.