Istavel D 10/50 Mg

ISTAVEL D 10/50 MG

Name:

• Brand Name: ISTAVEL D 10/50 MG
• Manufacturer: SUN PHARMA LABORATORIES LTD.

Composition: ISTAVEL D 10/50 MG contains a combination of two antidiabetic medications:

• Dapagliflozin: 10 mg
• Sitagliptin: 50 mg

Dapagliflozin is a sodium-glucose cotransporter-2 (SGLT-2) inhibitor that works by increasing the removal of excess sugar from the body through urine. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that helps regulate blood sugar levels by stimulating insulin release, especially after meals, and decreasing the amount of glucose the liver produces.

Uses: ISTAVEL D 10/50 MG is primarily used in the treatment of Type 2 diabetes mellitus in adults. It is prescribed to help control blood sugar levels, especially when diet, exercise, and other medications alone are not sufficient. This medicine also plays a role in preventing serious complications of diabetes, such as eyesight loss (retinopathy), kidney damage (nephropathy), nerve damage (neuropathy), diabetic foot ulcer, and delayed wound healing. It may also be used to treat chronic kidney disease in adults with reduced kidney function and can reduce the risk of heart attack, heart failure, or other cardiovascular events.

Dosage and Administration: ISTAVEL D 10/50 MG should be taken orally as advised by your doctor. It can be taken with or without food, but it is recommended to take it at the same time each day for optimal benefits. The tablet should be swallowed whole with a glass of water and not be crushed, cut, or chewed. Do not exceed the recommended dose, and do not stop taking the medication abruptly without consulting your doctor, as this may lead to an increase in blood sugar levels and associated complications.

Side Effects: Common side effects of ISTAVEL D 10/50 MG include:

• Diarrhea
• Hypoglycemia (low blood sugar)
• Headache
• Nausea and vomiting
• Urinary tract infection (UTI)
• Genital mycotic (fungal) infections
• Nasal congestion and sore throat (nasopharyngitis)
• Upper respiratory tract infection
• Dizziness or light-headedness
• Frequent urination
• Rashes

Serious side effects are less common but can include allergic reactions and, in some cases, harmful effects on the kidney or liver.

Precautions:

• Allergies: Inform your doctor if you are allergic to dapagliflozin, sitagliptin, or any other ingredients in the tablet.
• Medical Conditions: Before taking this medicine, inform your doctor if you have kidney or liver problems, heart disease, a urinary tract infection, type 1 diabetes mellitus, or diabetic ketoacidosis.
• Pregnancy and Breastfeeding: Limited information is available regarding the effect of this medicine on pregnant and breastfeeding women. It should be used during pregnancy only if clearly necessary and with caution in breastfeeding women after consulting a doctor.
• Alcohol: Avoid consumption of alcohol during treatment as it may cause serious side effects and interfere with blood sugar control.
• Interactions: Inform your doctor about all other medicines, herbals, or supplements you are taking. Caution is advised with diuretics (which may increase the risk of dehydration and low blood pressure) and other antidiabetic medicines like insulin or sulfonylureas (which may cause extremely low blood sugar levels).
• Dehydration: Drinking plenty of fluids is important to prevent dehydration, as this medicine increases glucose excretion through urine.
• Hygiene: Maintaining good hygiene can help prevent genital fungal infections.
• Monitoring: Regular monitoring of blood sugar levels is crucial while taking this medication.

Storage: Store ISTAVEL D 10/50 MG in a cool and dry place, away from direct sunlight, at a temperature below 30°C. Keep it out of the sight and reach of children and pets.

Frequently Asked Questions about ISTAVEL D 10/50 MG

ISTAVEL D 10/50 MG is a medication used to manage Type 2 diabetes mellitus. It contains two active ingredients: Dapagliflozin and Sitagliptin.

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What is ISTAVEL D 10/50 MG used for?

ISTAVEL D 10/50 MG is used to treat Type 2 diabetes mellitus in adults. It helps control high blood sugar levels, especially when diet, exercise, and other medications alone are not sufficient. It also aims to prevent serious diabetes-related complications such as eyesight loss, kidney damage, nerve damage, diabetic foot ulcers, and delayed wound healing. This medicine can also be used to treat chronic kidney disease in adults with reduced kidney function.

How does ISTAVEL D 10/50 MG work?

ISTAVEL D 10/50 MG combines two different mechanisms of action. Dapagliflozin, an SGLT2 inhibitor, works by increasing the removal of sugar from the body through the kidneys, leading to increased glucose excretion in the urine. Sitagliptin, a DPP-4 inhibitor, increases the levels of natural substances called incretins, which help regulate blood sugar by stimulating insulin release, particularly after meals, and by decreasing the amount of sugar the liver produces.

What is the usual dosage of ISTAVEL D 10/50 MG?

The exact dosage of ISTAVEL D 10/50 MG will be determined by your doctor, as it depends on your individual medical condition, age, and response to treatment. It should be taken exactly as prescribed by your doctor, swallowed whole with a glass of water, and not cut, broken, or chewed. It can be taken with or without food, but taking it at the same time each day is recommended for optimal benefits.

What are the possible side effects of ISTAVEL D 10/50 MG?

Common side effects may include urinary tract infections (UTIs), frequent urination, nasal congestion, sore throat, upper respiratory tract infections, headache, dizziness, nausea, vomiting, and diarrhea. Some individuals might also experience fungal infections in the genital area. More severe, but less common, side effects can include very low blood sugar (hypoglycemia) especially when used with insulin or sulphonylureas, and dehydration.

Is ISTAVEL D 10/50 MG safe during pregnancy or breastfeeding?

There is limited information on the effect of ISTAVEL D 10/50 MG in pregnant women. Therefore, it should not be used during pregnancy unless considered clearly necessary by a doctor. Similarly, it is not recommended for breastfeeding women as it is unknown if the medicine passes into human breast milk. Always consult your doctor if you are pregnant, planning a pregnancy, or breastfeeding.

Can it be taken with other medications?

ISTAVEL D 10/50 MG can interact with certain medications. Inform your doctor about all other medicines, herbal products, or supplements you are currently taking or might take to avoid possible interactions. Particular care should be taken if you are on diuretics (water pills), insulin, insulin secretagogues (like sulphonylureas), or medications for fungal infections (e.g., ketoconazole), bacterial infections (e.g., clarithromycin), HIV/AIDS (e.g., ritonavir), or heart failure (e.g., digoxin).

What precautions should be taken while using ISTAVEL D 10/50 MG?

Do not take ISTAVEL D 10/50 MG if you have Type 1 diabetes mellitus or severe kidney or liver disease. Inform your doctor if you have a history of kidney or liver issues, urinary tract infections, pancreatitis, gallstones, heart disease, or are taking medications for high blood pressure. It's crucial not to stop taking the medication abruptly, even if you feel better, as this can lead to increased blood sugar levels and risk of complications. Drink plenty of fluids to prevent dehydration. Avoid excessive alcohol consumption as it may interfere with blood sugar control and increase the risk of side effects like diabetic ketoacidosis.

What happens if a dose is missed?

If you miss a dose of ISTAVEL D 10/50 MG, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to compensate for the missed one.

How should ISTAVEL D 10/50 MG be stored?

Store ISTAVEL D 10/50 MG in a cool and dry place, away from direct sunlight, and below 30°C. Keep it out of the sight and reach of children and pets.