Mantedanib 100mg Cap

MANTEDANIB 100MG CAP

MANTEDANIB 100MG CAP, manufactured by Mankind Pharma Ltd., is a medication used to treat specific chronic and progressive conditions affecting the lungs.

• Name:

  • Brand Name: MANTEDANIB 100MG CAP
  • Common Name (Active Ingredient): Nintedanib 100mg

• Composition:

  • Each capsule contains Nintedanib 100mg. Nintedanib is classified as a tyrosine kinase inhibitor.

• Uses: MANTEDANIB 100MG CAP is prescribed for the treatment of:

  • Idiopathic Pulmonary Fibrosis (IPF), a chronic lung disease characterized by scarring and stiffening of lung tissue, leading to breathing difficulties.
  • Non-small cell lung cancer (NSCLC) of adenocarcinoma tumor histology, especially after first-line chemotherapy has not been effective.
  • Chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype.
  • Systemic sclerosis-associated interstitial lung disease (SSc-ILD), to slow the decline in pulmonary function. It works by blocking specific pathways involved in fibrosis and cancer cell proliferation, thereby helping to slow disease progression and reduce scarring.

• Dosage and Administration:

  • Take the capsule orally with food.
  • It should be taken at approximately the same time each day, typically twice daily (e.g., morning and evening), about 12 hours apart.
  • Swallow the capsule whole with water; do not chew, crush, or open it.
  • The exact dose and duration of treatment will be determined by a healthcare professional based on the specific condition and patient response.

• Side Effects: Commonly reported side effects include:

  • Diarrhea (very common)
  • Nausea
  • Abdominal pain
  • Vomiting
  • Loss of appetite
  • Headache
  • Weight loss
  • High blood pressure
  • Abnormal liver function tests
  • Tiredness and indigestion Most side effects are temporary, but persistent or severe symptoms should be reported to a doctor.

• Precautions:

  • Pregnancy and Breastfeeding: MANTEDANIB is unsafe during pregnancy (Category D) and is likely unsafe during breastfeeding due to potential harm to the baby. Women of childbearing potential must use highly effective contraception during treatment and for at least three months after.
  • Liver and Kidney Impairment: Not recommended for moderate to severe liver disease. Use with caution in patients with mild liver impairment (dose adjustment may be necessary) and kidney impairment. Liver function should be monitored regularly.
  • Bleeding and Blood Clots: Exercise caution in patients with a history of bleeding problems, those at high risk of blood clots, or individuals taking blood-thinning medications.
  • Gastrointestinal Disorders: May exacerbate existing gastrointestinal conditions and increase the risk of perforation.
  • Alcohol Consumption: Consult a doctor regarding alcohol consumption during treatment.
  • Driving: May cause side effects like tiredness or dizziness that could impair the ability to drive or operate machinery.
  • Drug Interactions: Inform your doctor about all other medications, including antifungals (e.g., ketoconazole) and anticonvulsants (e.g., carbamazepine), as they may interact with MANTEDANIB.

• Storage:

  • Store in a refrigerator between 2-8°C, or in a cool place at 10-25°C or below 30°C.
  • Do not freeze.
  • Keep out of the reach and sight of children.

Here are frequently asked questions about Mantedanib 100mg Capsule:

What is Mantedanib 100mg Capsule used for?

Mantedanib 100mg Capsule, containing Nintedanib, is primarily used to treat idiopathic pulmonary fibrosis (IPF), a chronic lung disease causing lung scarring. It is also used to manage chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype, systemic sclerosis-associated interstitial lung disease (SSc-ILD), and advanced non-small cell lung cancer (NSCLC) of the adenocarcinoma type after first-line chemotherapy.

How does Mantedanib 100mg Capsule work?

Mantedanib 100mg Capsule is a kinase inhibitor that works by blocking several receptor tyrosine kinases. These enzymes are involved in processes that lead to fibrosis (scarring) in the lungs and support tumor growth in certain cancers. By inhibiting these targets, Mantedanib helps slow the progression of lung fibrosis and cancer cell proliferation.

What is the usual dosage for Mantedanib 100mg Capsule?

The typical recommended dosage is one 100mg capsule taken twice daily, approximately 12 hours apart, with food. It is crucial to follow your doctor's specific instructions, as the dosage may vary based on your condition and response to treatment.

What are the possible side effects of Mantedanib 100mg Capsule?

Common side effects include diarrhea, nausea, abdominal pain, vomiting, decreased appetite, headache, weight loss, high blood pressure (hypertension), and elevations in liver enzymes. More serious, though rare, side effects can include liver injury, heart attack, bleeding problems, kidney issues, and gastrointestinal perforation.

Is Mantedanib 100mg Capsule safe during pregnancy or breastfeeding?

Mantedanib 100mg Capsule is contraindicated during pregnancy due to definite evidence of risk to the developing baby. If you are pregnant or planning to conceive, discuss this with your doctor. For breastfeeding mothers, doctor consultation is advised as the medicine may pass into breast milk and potentially harm the baby. Effective contraception is important for both males and females during treatment.

Can Mantedanib 100mg Capsule be taken with other medications?

Mantedanib can interact with certain medications. Antifungals like ketoconazole and itraconazole may increase its levels, potentially leading to more side effects. Anticonvulsants such as carbamazepine and phenytoin may reduce Mantedanib's effectiveness. Blood-thinning medicines like warfarin and heparin can increase the risk of bleeding when taken with Mantedanib. It may also interact with St. John's wort, laxatives, and aspirin. Always inform your doctor about all medications you are taking.

What precautions should be taken while taking Mantedanib 100mg Capsule?

Take the capsule whole with food and a glass of water; do not chew, crush, or open it. Inform your doctor about any pre-existing conditions, especially cardiovascular disease, gastrointestinal disorders, liver or kidney problems, and bleeding disorders. Regular monitoring of liver function and blood pressure will be performed by your doctor. It is advised to consult your doctor regarding alcohol consumption. If you experience side effects like headache or dizziness, avoid driving or operating machinery. Mantedanib is not recommended for children under 18 years of age.

What happens if a dose of Mantedanib 100mg Capsule is missed?

If you miss a dose, simply continue with your regular dosing schedule. Do not take extra capsules or a double dose to make up for the missed one.

How should Mantedanib 100mg Capsule be stored?

Mantedanib 100mg Capsule should be kept in its original packaging at room temperature (below 25°C or below 30°C). Protect the medicine from excessive heat and moisture. Keep it out of sight and reach of children.