Myoril Inj

MYORIL INJ

• Name: Myoril Injection
• Composition: Each ampoule typically contains Thiocolchicoside 4 mg/2 ml. Thiocolchicoside is a semi-synthetic derivative of colchicoside, acting as a muscle relaxant.
• Uses: Myoril Injection is prescribed as an adjuvant treatment for painful muscular contractions in adults and adolescents aged 16 years and older. It is used for acute conditions related to the spinal column and helps relieve muscle stiffness and improve movement in conditions such as degenerative vertebral disorders, vertebral static problems, dorsal pain, low back pain, torticollis (neck muscle contractions), and certain neurological and traumatological disorders.
• Dosage and Administration: For intramuscular administration, the recommended and maximal dose is 4 mg every 12 hours (i.e., 8 mg per day). The treatment duration is strictly limited to 5 consecutive days. Myoril Injection should be administered by a healthcare professional in a hospital setting and should not be self-administered.
• Side Effects: Common side effects may include drowsiness, dizziness, nausea, vomiting, diarrhea, dry mouth, abdominal pain, itching, skin rash, and pain at the injection site. More serious concerns include allergic reactions, severe dizziness or fainting, and potential liver problems (indicated by yellowing of skin and eyes or dark urine). Thiocolchicoside has been linked to genotoxicity and fertility risks.
• Precautions: Myoril Injection is contraindicated during pregnancy, lactation, and in women of childbearing potential not using effective contraception due to potential harm to the unborn child and impairment of male fertility. It is not recommended for children and adolescents below 16 years of age. Caution is advised in patients with kidney or liver diseases, and those with a history of seizures. Due to potential drowsiness, patients should avoid driving or operating machinery and refrain from consuming alcohol during treatment. Doses exceeding recommended limits or long-term use should be avoided.
• Storage: Store in a cool and dry place, typically below 25°C or 30°C, and protect from direct sunlight. Keep out of the reach and sight of children.

MYORIL INJ (Thiocolchicoside Injection) - Frequently Asked Questions

What is MYORIL INJ used for?

MYORIL INJ is a muscle relaxant primarily used in adults and adolescents aged 16 years and older. It is an adjuvant treatment for painful muscular contractions associated with acute conditions of the spinal column, such as low back pain, neck pain (torticollis), and other musculoskeletal disorders. It can also be used for pain management, postoperative recovery, and certain neurological disorders involving muscle stiffness and spasms.

How does MYORIL INJ work?

MYORIL INJ contains Thiocolchicoside, which works on the central nervous system, specifically targeting the brain and spinal cord. It acts as a muscle relaxant by modulating the activity of certain chemicals, such as by activating GABA (gamma-aminobutyric acid) inhibitory motor pathways and inhibiting glycine receptors. This action helps to relieve muscle stiffness and spasms, thereby improving muscle movement and reducing pain. It also possesses anti-inflammatory and analgesic (pain-relieving) properties.

What is the usual dosage for MYORIL INJ?

For intramuscular (IM) administration, the recommended and maximum dose of Thiocolchicoside is 4 mg every 12 hours, totaling 8 mg per day. The treatment duration should not exceed 5 consecutive days. It is crucial to strictly adhere to the prescribed doses and duration of treatment, as higher doses or prolonged use can potentially lead to cell damage.

What are the possible side effects of MYORIL INJ?

Common side effects may include drowsiness, dizziness, nausea, vomiting, diarrhea, dry mouth, abdominal pain, gas, and reactions at the injection site (pain, swelling, redness). Although rare, more serious side effects can include allergic reactions (such as rash, itching, or swelling), severe dizziness, fainting, or liver problems, which might be indicated by jaundice (yellowing of skin or eyes) or dark urine. If you experience any severe or persistent side effects, you should consult your doctor.

Is MYORIL INJ safe during pregnancy or breastfeeding?

No, MYORIL INJ is contraindicated during pregnancy, in women who might become pregnant and are not using effective contraception, and during breastfeeding. This is because the medicine may harm the unborn child, passes into breast milk, and has been linked to potential genotoxicity and fertility risks.

Can MYORIL INJ be taken with other medications?

Caution is advised when MYORIL INJ is taken with other medications. It can interact with central nervous system (CNS) depressants, including benzodiazepines, opioids, and alcohol, potentially increasing drowsiness and sedation. It may also interact with anticoagulants (blood thinners), other muscle relaxants, nonsteroidal anti-inflammatory drugs (NSAIDs), and corticosteroids. Always inform your doctor about all prescription, over-the-counter, and herbal medications you are currently taking to avoid potential interactions.

What precautions should be taken while using MYORIL INJ?

Strictly follow your doctor's instructions regarding the dose and duration of treatment (maximum 5 days for injections). MYORIL INJ is not recommended for children under 16 years of age. Use with caution if you have liver impairment or a history of seizures. It is advisable to avoid alcohol consumption while on this medication as it can increase drowsiness. Due to the potential for drowsiness and dizziness, do not drive or operate heavy machinery until you understand how the medicine affects you.

What happens if a dose of MYORIL INJ is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a forgotten dose.

How should MYORIL INJ be stored?

MYORIL INJ should be stored in a cool and dry place, away from direct sunlight. It should be kept out of the reach and sight of children. The recommended storage temperature is typically between 15°C and 25°C, or below 30°C.