Emigo Oral Solution 30 Ml

EMIGO ORAL SOLUTION 30 ML by ZUVENTUS HEALTHCARE LTD.

Emigo Oral Solution is an antiemetic medicine primarily used to prevent and treat nausea and vomiting in children. It is manufactured by Zuventus Healthcare Ltd..

• Name:

  • Common Name: Emigo Oral Solution, Emigo Syrup
  • Brand Name: Emigo

• Composition:

  • Active Ingredient: Ondansetron (2 mg per 5 mL, as ondansetron hydrochloride)

• Uses: Emigo Oral Solution is prescribed to manage nausea and vomiting in children associated with various medical conditions and treatments, including:

  • Cancer chemotherapy
  • Radiation therapy
  • Post-surgery nausea and vomiting
  • Gastroenteritis (stomach/intestinal infection)
  • Vomiting caused by certain medications, such as painkillers It is indicated for use in infants and children aged 6 months to 12 years, particularly for pediatric gastroenteritis.

• Dosage and Administration:

  • Emigo Oral Solution is for oral administration. The bottle should be shaken well before each use, and the correct dose measured using the provided measuring cup or spoon.
  • The exact dosage is determined by a doctor and may vary based on the child's age, weight, body surface area, and the severity of the condition.
  • It is crucial not to exceed the recommended dosage.
  • Typically, it is administered 30 minutes before chemotherapy, 1-2 hours before radiation therapy, or 1 hour before surgery.
  • It can be given with or without food. If a child vomits within one hour of administration, the same dose may need to be given again.

• Side Effects:

  • Common Side Effects: Headache, constipation, diarrhea, fatigue, dizziness, drowsiness, a feeling of warmth or flushing, and stomach pain. These usually resolve as the body adjusts to the medicine.
  • Serious Side Effects: Rare allergic reactions can occur, presenting as sudden wheeziness, chest pain, difficulty breathing, swelling of the face, lips or tongue, skin rash, or feeling faint. Ondansetron may also cause QT prolongation, a heart rhythm problem, and cases of Torsade de Pointes have been reported.

• Precautions:

  • Emigo Oral Solution should not be given to children allergic to ondansetron or other 5-HT3 receptor antagonists like granisetron or palonosetron.
  • Caution is advised in children with liver disease, kidney disease, heart conditions (e.g., congestive heart failure, irregular heartbeats, congenital long QT syndrome), electrolyte imbalances (potassium or magnesium levels should be corrected), severe constipation, or a blockage in the stomach or intestines.
  • As it is sugar-based, diabetic patients require caution and a doctor's consultation.
  • Drug Interactions:
    • Apomorphine: Concomitant use is contraindicated due to the risk of severe hypotension and unconsciousness.
    • Tramadol: May reduce its pain-relieving effect.
    • Serotonergic medicines (e.g., SSRIs, SNRIs, MAOIs): Increased risk of serotonin syndrome.
    • Medicines affecting heart rhythm: Caution with drugs like haloperidol, methadone, amiodarone, anthracyclines, beta-blockers, erythromycin, or ketoconazole.
    • Other: Carbamazepine, phenytoin, and rifampicin can also interact with ondansetron.

• Storage:

  • Store Emigo Oral Solution at room temperature, not exceeding 30°C.
  • Protect it from direct sunlight and moisture.
  • Keep the medicine out of the reach and sight of children.
  • Keep the bottle tightly capped after use.

EMIGO ORAL SOLUTION 30 ML contains ondansetron, an anti-emetic medicine used to prevent nausea and vomiting.

What is EMIGO ORAL SOLUTION used for?

EMIGO ORAL SOLUTION is primarily used to prevent and treat nausea and vomiting. This often includes nausea and vomiting associated with chemotherapy for cancer, radiation therapy, and post-surgery. It can also be used to manage vomiting caused by stomach or intestinal infections, and as a side effect of certain painkillers in children.

How does EMIGO ORAL SOLUTION work?

EMIGO ORAL SOLUTION works by blocking the action of serotonin, a natural chemical substance in the body that can trigger nausea and vomiting. It specifically acts as a selective antagonist of the serotonin 5-HT3 receptor type, thereby preventing these symptoms.

What is the usual dosage for EMIGO ORAL SOLUTION?

The dosage of EMIGO ORAL SOLUTION depends on the treatment, the patient's age (especially for children), and body weight or surface area.

• For chemotherapy-induced nausea and vomiting:
  • Adults and adolescents (12 years and older): A typical dose is 8 mg (10 mL of 2 mg/5 mL solution) taken 30 minutes before chemotherapy, followed by another 8 mg dose 8 hours later. This may continue with 8 mg twice a day for 1 to 2 days after chemotherapy completion. For highly emetogenic chemotherapy, a single 24 mg dose (three 8 mg doses or 12 x 5ml spoonfuls of 2mg/5ml solution) can be given 30 minutes before treatment.
  • Children (4 to 11 years): A typical dose is 4 mg (one 5 mL spoonful of 2 mg/5 mL solution) given 30 minutes before chemotherapy, with subsequent 4 mg doses 4 and 8 hours after the first. Then, 4 mg every 8 hours for 1 to 2 days.
• For radiation-induced nausea and vomiting:
  • Adults: 8 mg (10 mL of 2 mg/5 mL solution) taken 1 to 2 hours before radiation therapy, followed by 8 mg every 8 hours for 1 to 2 days.
• For postoperative nausea and vomiting:
  • Adults: A typical dose is 16 mg (four 5 mL spoonfuls of 2 mg/5 mL solution) taken 1 hour before anesthesia. Always follow your doctor's prescribed dose and duration. If a dose is vomited within 30-60 minutes, the dose may be repeated.

What are the possible side effects of EMIGO ORAL SOLUTION?

Common side effects can include headache, constipation, a feeling of warmth or flushing, diarrhea, fatigue, dizziness, and drowsiness. More serious, though rare, side effects can include allergic reactions (e.g., skin rash, hives, swelling of the face/lips/tongue, difficulty breathing), chest pain, heart rhythm changes (fast or irregular heartbeat, QT prolongation), and symptoms of serotonin syndrome (e.g., irritation, confusion, shakiness, sweating, high fever). If any severe side effects occur, contact your doctor immediately.

Is EMIGO ORAL SOLUTION safe during pregnancy or breastfeeding?

EMIGO ORAL SOLUTION (ondansetron) should generally be avoided during the first trimester of pregnancy due to a potential slight increase in the risk of a baby being born with a cleft lip and/or cleft palate. If you are pregnant, think you might be pregnant, or are planning a baby, discuss the potential benefits and risks with your doctor.

It is not recommended to breastfeed while taking ondansetron, as small amounts can pass into breast milk. Consult your doctor for advice if you are breastfeeding.

Can EMIGO ORAL SOLUTION be taken with other medications?

EMIGO ORAL SOLUTION can interact with certain medications. Inform your doctor or pharmacist about all medicines you or your child are taking, including over-the-counter and herbal remedies.

• Do not take with apomorphine (used for Parkinson's disease) as it can cause severely low blood pressure and loss of consciousness.
• Caution is needed with medicines that affect heart rhythm (e.g., certain antibiotics like erythromycin, antifungals like ketoconazole, antiarrhythmics like amiodarone, beta-blockers, haloperidol, methadone), as ondansetron can prolong the QT interval, increasing the risk of irregular heartbeats.
• Combining with other serotonergic agents such as SSRIs (e.g., fluoxetine, sertraline) and SNRIs (e.g., venlafaxine, duloxetine) used for depression and anxiety can increase the risk of serotonin syndrome.
• Painkillers like tramadol may be less effective when taken with EMIGO ORAL SOLUTION.

What precautions should be taken?

Before taking EMIGO ORAL SOLUTION, inform your doctor if you or your child have:

• Heart problems, such as heart failure, an uneven heartbeat (arrhythmias), or congenital long QT syndrome.
• Liver problems.
• A blockage in the gut or severe constipation, as the medicine can affect transit time through the digestive tract.
• Problems with blood salt levels (e.g., potassium, sodium, magnesium) or dehydration.
• Allergies to ondansetron or similar medicines like granisetron or palonosetron.

What happens if a dose is missed?

If a dose is missed and you feel sick or vomit, take the missed dose as soon as possible. Then, take the next dose at the usual scheduled time. Do not take a double dose to make up for a forgotten dose. If you miss a dose but do not feel sick, simply take the next dose when it is due.

How should EMIGO ORAL SOLUTION be stored?

EMIGO ORAL SOLUTION should be stored at room temperature, away from light and moisture, and kept out of the reach and sight of children and pets. Do not flush unused or expired medicines down the toilet or pour them into a drain.