Here is a detailed product description for MOTINORM DT 10 MG:

---

MOTINORM DT 10 MG

Name

• Brand Name: MOTINORM DT 10 MG
• Common Name: Domperidone Dispersible Tablet

Composition

• Active Ingredient: Domperidone 10 mg

Uses

MOTINORM DT 10 MG is primarily used to relieve symptoms associated with various gastrointestinal conditions. It acts as an anti-emetic and prokinetic agent.

• Nausea and Vomiting: Effective for nausea and vomiting caused by various factors, including infections, motion sickness, post-operative effects, chemotherapy, radiotherapy, drugs, and migraines.
• Indigestion (Dyspepsia): Manages symptoms like bloating, fullness, early satiety, stomach discomfort, and heartburn by promoting gastric emptying and increasing upper gastrointestinal motility.
• Gastroparesis: Helps in stimulating gastric motility for patients with delayed stomach emptying.
• Gastroesophageal Reflux Disease (GERD): Aids in managing GERD symptoms by reducing stomach acid and promoting gastric emptying.
• Lactation: Occasionally prescribed to boost milk production when other methods are ineffective.

Dosage and Administration

MOTINORM DT 10 MG is typically taken half an hour before meals. For the dispersible tablet form, it should be dissolved in a glass of water before consumption. The dosage and duration are determined by a healthcare professional based on the patient's condition, age, and body weight.

• Adults: Typically 10-20 mg every 4-8 hours. The maximum daily dose should not exceed 80 mg.
• Adolescents (12-18 years): For those weighing more than 35 kg, 0.2-0.4 mg/kg every 4-8 hours.
• Duration: For acute nausea and vomiting, treatment duration should generally not exceed seven days.
• Restrictions: Not recommended for adolescents weighing less than 35 kg or children younger than 12 years of age.

Side Effects

Most side effects are temporary and resolve over time, but some can be serious.

• Common Side Effects: Dry mouth, headache, stomach pain, dizziness, drowsiness, diarrhea, itchy skin, and abdominal cramps.
• Serious Side Effects (Contact a doctor immediately if experienced): Irregular heartbeat (arrhythmia), chest pain, swelling of the face, lips, eyelids, tongue, hands, and feet, difficulty breathing, extreme tiredness, convulsions, and cardiac arrest.

Precautions

• Cardiac Risks: Prolonged intake, especially in elderly individuals (over 60 years) or at doses exceeding 30 mg daily, may increase the risk of heart rhythm disorders and cardiac arrest.
• Liver and Kidney Impairment: Use with caution in patients with mild to moderate liver impairment or kidney problems; dose adjustment may be necessary. Not recommended for severe liver impairment.
• Contraindications: Do not use if hypersensitive to domperidone, or in cases of gastrointestinal bleeding, obstruction, perforation, a pituitary gland tumor (prolactinoma), known QTc prolongation, or electrolyte imbalances (magnesium, potassium, calcium).
• Pregnancy and Breastfeeding: Generally not recommended during pregnancy or breastfeeding, though it may be prescribed in specific cases to increase milk supply under strict medical supervision.
• Drug Interactions: Inform your doctor about all other medications being taken, as interactions can occur with antifungals, antibiotics, heart medications, antidepressants, and antivirals. Avoid concomitant use with antacids.
• Alcohol and Driving: Avoid alcohol consumption as it may cause excessive drowsiness. Due to potential dizziness and sleepiness, avoid driving or operating machinery until you know how the medicine affects you.

Storage

• Store in a cool and dry place, away from direct sunlight.
• Keep out of sight and reach of children.
• Maintain storage temperature between 10ºC to 25ºC or below 30ºC.

---

MOTINORM DT 10 MG is a medication manufactured by MEDLEY PHARMACEUTICALS LTD. and contains Domperidone as its active ingredient. It is primarily used to relieve symptoms affecting the gastrointestinal tract.

Here are some frequently asked questions about MOTINORM DT 10 MG:

What is MOTINORM DT 10 MG used for?

MOTINORM DT 10 MG is primarily used to treat nausea and vomiting in adults and adolescents 12 years or older. It also helps in treating indigestion, heartburn, and conditions like gastroparesis (slow stomach emptying), functional dyspepsia (bloating, early fullness, stomach discomfort), and sometimes symptoms related to Gastroesophageal Reflux Disease (GERD). It can also be used for nausea and vomiting associated with motion sickness, migraines, chemotherapy, or radiotherapy.

How does MOTINORM DT 10 MG work?

MOTINORM DT 10 MG contains domperidone, which works as a dopamine antagonist. It blocks certain receptors, like dopamine and serotonin, that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) in the brain, thereby preventing nausea and vomiting symptoms. Additionally, it acts as a prokinetic agent, increasing the motility of the upper gastrointestinal tract and decreasing stomach emptying time, which helps alleviate indigestion symptoms.

What is the usual dosage of MOTINORM DT 10 MG?

MOTINORM DT 10 MG should be taken as prescribed by your doctor. It is typically recommended to take it before meals, often half an hour before each meal. The usual starting dose for adults is 10 mg, taken up to three times a day, with a maximum recommended dose of 30 mg per day. The dosage and duration depend on your condition and response to the medicine. For dispersible tablets, dissolve them in the specified amount of water and consume immediately.

What are the possible side effects of MOTINORM DT 10 MG?

Common side effects of MOTINORM DT 10 MG include dry mouth, headache, stomach pain, diarrhea, and dizziness/drowsiness. More serious, but less common, side effects can include skin rash, irregular heartbeat (arrhythmia), chest pain, and extreme tiredness. Prolonged intake, especially in elderly individuals or at doses higher than 30 mg daily, may increase the risk of heart rhythm disorders and cardiac arrest. If you experience palpitations, breathing difficulties, or loss of consciousness, contact your doctor immediately.

Is MOTINORM DT 10 MG safe during pregnancy or breastfeeding?

MOTINORM DT 10 MG is generally not recommended during pregnancy due to limited safety information and animal studies showing potential harmful effects on the developing baby. Pregnant individuals should consult their doctor before taking this medicine.

During breastfeeding, MOTINORM DT 10 MG is also generally not recommended, as a small amount passes into breast milk and may cause unwanted side effects in the baby. However, in some specific cases, domperidone may be used under medical supervision to help increase milk supply if your physician deems it necessary and the benefits outweigh the risks.

Can MOTINORM DT 10 MG be taken with other medications?

MOTINORM DT 10 MG can interact with several other medications. It is crucial to inform your doctor about all medications you are taking. Concomitant use with certain antifungal medications (like ketoconazole and fluconazole), antibiotics (like erythromycin and clarithromycin), antidepressants (like fluoxetine), and antivirals (like ritonavir) can increase the levels of domperidone and potentially raise the risk of heart-related side effects. It should also be used with caution with medicines for heart problems or high blood pressure, and should not be taken simultaneously with antacids, as they can reduce its absorption.

What precautions should be taken while using MOTINORM DT 10 MG?

Before taking MOTINORM DT 10 MG, inform your doctor if you have any liver, kidney, or heart problems, including a history of heart rhythm disorders. Patients with severe liver impairment should generally avoid this medicine. Caution is also advised for patients with certain intestinal problems like bleeding ulcers, obstruction, or perforation. Adolescents weighing less than 35 kg or children younger than 12 years should not be given MOTINORM DT 10 MG unless specifically advised by a doctor. This medicine may cause dizziness or drowsiness, so avoid driving or operating machinery until you know how it affects you. It's advisable to limit or avoid alcohol consumption as it may enhance side effects like drowsiness.

What happens if a dose of MOTINORM DT 10 MG is missed?

If you miss a dose of MOTINORM DT 10 MG, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one.

How should MOTINORM DT 10 MG be stored?

MOTINORM DT 10 MG should be stored in a cool and dry place, away from direct sunlight, and below 25°C or 30°C, depending on the specific product instructions. Keep the medicine out of the sight and reach of children.