Niftran 100 Mg Capsule (10 Cap)

NIFTRAN 100 MG CAPSULE

Niftran 100 MG Capsule is an antibiotic medication manufactured by Sun Pharmaceutical Industries Ltd., primarily used to treat and prevent bacterial infections of the urinary tract.

Composition

Niftran 100 MG Capsule contains Nitrofurantoin 100 mg as its active ingredient. Nitrofurantoin works by entering bacterial cells and destroying their genetic material, thereby killing the bacteria or inhibiting their growth by interfering with essential biochemical processes and protein production required for survival.

Uses

This medicine is prescribed for the management and prevention of various bacterial infections, particularly those affecting the urinary tract.

• Urinary Tract Infections (UTIs): It is effective against UTIs caused by susceptible bacteria such as E. coli, enterococci, staphylococci, Citrobacter, Klebsiella, and Enterobacter.
• Bladder Infections (Cystitis): Niftran 100 MG Capsule treats bladder infections by killing the causative bacteria, helping to relieve symptoms like burning during urination and frequent urination.
• Kidney Infections (Pyelonephritis): It is also used to treat kidney infections.
• Prevention of Recurrent UTIs: It may be prescribed for long-term prevention of recurrent urinary tract infections, often at a lower daily dose.

Dosage and Administration

Niftran 100 MG Capsule should be taken exactly as prescribed by a doctor.

• Typical Dosage: For treating UTIs, the usual adult dosage is typically 50 mg to 100 mg, taken once or twice a day, or 100 mg taken twice a day as slow-release capsules. For long-term prevention, a dose of 50 mg to 100 mg once daily at bedtime is common.
• Administration: Swallow the capsule whole with a glass of water or milk. It is crucial to take Niftran with food or milk to enhance absorption and minimize stomach upset, such as nausea.
• Duration: Complete the full course of treatment as prescribed, even if symptoms improve, to ensure complete eradication of the infection and prevent antibiotic resistance.

Side Effects

Common side effects are usually temporary and may include:

• Nausea
• Vomiting
• Diarrhea
• Loss of appetite
• Headaches
• Flatulence
• Urine discoloration (dark yellow or brown)

Serious side effects, though rare, can occur:

• Muscle weakness (especially in people with myasthenia gravis)
• Peripheral neuropathy (numbness, tingling)
• Hepatitis or liver damage
• Lung inflammation (pulmonary toxicity), particularly with long-term use
• Hemolytic anemia, especially in patients with G6PD deficiency

If any side effects persist or worsen, consult a doctor immediately.

Precautions

• Allergies: Do not take Niftran 100 MG Capsule if you are allergic to nitrofurantoin or any of its components.
• Kidney Impairment: It is contraindicated in patients with severe kidney disease or renal dysfunction (eGFR less than 45 ml/minute), as it may not be effective and could cause harm.
• Liver Problems: Use with caution in patients with liver-related diseases; it is contraindicated in those with a history of hepatic impairment or cholestatic jaundice with nitrofurantoin.
• Pregnancy and Breastfeeding: Niftran should generally be avoided during pregnancy, especially during labor and delivery, due to potential risks to the baby. It is excreted in breast milk, so caution is advised, and a doctor should be consulted.
• G6PD Deficiency: Exercise caution in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the increased risk of hemolytic anemia.
• Myasthenia Gravis: May worsen muscle weakness in individuals with myasthenia gravis.
• Photosensitivity: Avoid prolonged exposure to sunlight as it may increase phototoxicity or photosensitivity.
• Alcohol: Avoid consuming alcohol during treatment as it may cause adverse reactions like flushing and increased heart rate.
• Dietary Interactions: Avoid grapefruit.
• Driving and Operating Machinery: Niftran may cause dizziness and drowsiness, so avoid activities requiring alertness if affected.
• Other Conditions: Inform your doctor if you have blood disorders (like porphyria), diabetes, anemia, vitamin B deficiency, epilepsy, or an irregular heartbeat (QT prolongation).
• Pediatric Use: Not recommended for newborns and pediatric patients below 12 years of age.

Storage

Store Niftran 100 MG Capsule in a cool and dry place, away from direct sunlight and moisture, preferably between 10°C to 25°C or below 30°C. Keep it out of sight and reach of children. Dispose of unused or expired medicine appropriately.

Here are the frequently asked questions about NIFTRAN 100 MG CAPSULE:

What is Niftran 100 mg Capsule used for?

Niftran 100 mg Capsule is an antibiotic primarily used to treat and prevent bacterial infections of the urinary tract (UTIs), including bladder infections (cystitis), kidney infections, pyelonephritis, and prostatitis. It helps to relieve symptoms such as frequent urination, burning sensations, and pain during urination.

How does Niftran 100 mg Capsule work?

Niftran 100 mg Capsule contains nitrofurantoin as its active ingredient. It works by killing the bacteria that cause urinary tract infections. Nitrofurantoin enters bacterial cells and interferes with essential biochemical processes, inhibiting the production of proteins, disrupting DNA synthesis, and weakening bacterial cell walls, ultimately leading to bacterial cell death.

What is the usual dosage of Niftran 100 mg Capsule?

For adults, the usual dosage to treat a urinary tract infection is typically one 100 mg capsule taken twice a day, with food. For long-term prevention of recurrent UTIs, the dose is usually 50 mg to 100 mg once daily at bedtime. It is crucial to take the medicine exactly as prescribed by your doctor and complete the full course of treatment, even if symptoms improve quickly.

What are the possible side effects of Niftran 100 mg Capsule?

Common side effects may include nausea, vomiting, diarrhea, loss of appetite, headache, flatulence, and dizziness. More serious but less common side effects can include fever, chills, skin rash, burning or tingling sensations (peripheral neuropathy), lung toxicity, liver damage, and hemolytic anemia. If side effects persist or worsen, consult your doctor immediately.

Is Niftran 100 mg Capsule safe during pregnancy or breastfeeding?

Niftran 100 mg Capsule is generally not recommended for use during pregnancy, especially in the later stages (38-42 weeks or during labor and delivery), due to the potential risk of hemolytic anemia in the newborn. If you are breastfeeding, caution should be exercised as the medicine is excreted in breast milk. It is advisable to consult your doctor to discuss the risks and benefits before taking this medicine while pregnant or breastfeeding.

Can Niftran 100 mg Capsule be taken with other medications?

Niftran 100 mg Capsule may interact with certain medications. Inform your doctor about all medicines, supplements, and herbal products you are currently taking. Particular caution is advised if you are taking antacids (especially those containing magnesium trisilicate), anti-gout medicines like probenecid and sulfinpyrazone, or carbonic anhydrase inhibitors. Oral contraceptives may also have reduced effectiveness.

What precautions should be taken while taking Niftran 100 mg Capsule?

It should be used with caution or avoided in individuals with severe kidney or liver problems, acute porphyria, G6PD deficiency, anemia, diabetes, vitamin B deficiency, or lung disease. Alcohol consumption should be avoided. Due to potential dizziness or drowsiness, avoid driving or operating heavy machinery if affected. Always complete the full prescribed course of antibiotics, and maintain good personal hygiene and hydration.

What happens if a dose of Niftran 100 mg Capsule is missed?

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

How should Niftran 100 mg Capsule be stored?

Niftran 100 mg Capsule should be stored in a cool and dry place, protected from sunlight and moisture. Keep it out of sight and reach of children and pets. Discard any unused or expired medicine appropriately.

Does Niftran 100 mg Capsule change urine color?

Yes, Niftran 100 mg Capsule can cause your urine to turn a dark yellow or brown color. This is a normal and harmless effect and is not a cause for concern. The urine color will return to normal after you stop taking the medicine.